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[1]
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PROTEIN SEQUENCE.
TISSUE=Hypothalamus;
DOI=10.1016/S0092-8674(00)80949-6; PubMed=9491897 [NCBI, ExPASy, EBI, Israel, Japan]
Sakurai T.,
Amemiya A.,
Ishii M.,
Matsuzaki I.,
Chemelli R.M.,
Tanaka H.,
Williams S.C.,
Richardson J.A.,
Kozlowski G.P.,
Wilson S.,
Arch J.R.S.,
Buckingham R.E.,
Haynes A.C.,
Carr S.A.,
Annan R.S.,
McNulty D.E.,
Liu W.-S.,
Terrett J.A.,
Elshourbagy N.A., ![]()
Bergsma D.J.,
Yanagisawa M.;
"Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior.";
Cell 92:573-585(1998).
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- FUNCTION: Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity (By similarity).
- SUBCELLULAR LOCATION: Rough endoplasmic reticulum (By similarity). Cytoplasmic vesicle (By similarity). Cell junction, synapse (By similarity). Note=Associated with perikaryal rough endoplasmic reticulum as well as cytoplasmic large granular vesicles at synapses (By similarity).
- SIMILARITY: Belongs to the orexin family.
- WEB RESOURCE: Name=Protein Spotlight; Note=Qui dort dine - Issue 15 of October 2001; URL="http://www.expasy.org/spotlight/back_issues/sptlt015.shtml";.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 33 AA [This is the length of the unprocessed precursor] |
Molecular weight: 3583 Da [This is the MW of the unprocessed precursor] |
CRC64: 8C16A02AA7CBFBD5 [This is a checksum on the sequence] |
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10 20 30
QPLPDCCRQK TCSCRLYELL HGAGNHAAGI LTL
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P56717 in FASTA format |
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