[1]	NUCLEOTIDE SEQUENCE [MRNA]. STRAIN=CD-1; DOI=10.1006/abbi.1998.0806; PubMed=9721182 [NCBI, ExPASy, EBI, Israel, Japan] Luo G., Zeldin D.C., Blaisdell J.A., Hodgson E., Goldstein J.A.; "Cloning and expression of murine CYP2Cs and their ability to metabolize arachidonic acid."; Arch. Biochem. Biophys. 357:45-57(1998).
[2]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. STRAIN=FVB/N; TISSUE=Liver; DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan] The MGC Project Team; "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."; Genome Res. 14:2121-2127(2004).

Comments

FUNCTION: Metabolizes arachidonic acid to produce 12-hydroxyeicosatetraenoic acid (HETE).
CATALYTIC ACTIVITY: RH + reduced flavoprotein + O₂ = ROH + oxidized flavoprotein + H₂O.
COFACTOR: Heme group (By similarity).
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
TISSUE SPECIFICITY: Liver.
INDUCTION: P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.
SIMILARITY: Belongs to the cytochrome P450 family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AF047542; AAD13719.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC057912; AAH57912.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

UniGene

Mm.439860

3D structure databases

HSSP

P00179; 1DT6. [HSSP ENTRY / PDB]

SMR

P56654; 44-489.

ModBase

P56654.

Organism-specific databases

MGI

MGI:1306806; Cyp2c37.

Gene expression databases

ArrayExpress

P56654; -.

GermOnline

ENSMUSG00000042248; Mus musculus.

Ontologies

GO:0005789;	Cellular component: endoplasmic reticulum membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0005792;	Cellular component: microsome (inferred from electronic annotation from UniProtKB-KW).
GO:0050381;	Molecular function: unspecific monooxygenase activity (inferred from electronic annotation from EC).
GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR001128; Cyt_P450.
IPR002401; Cyt_P450_E_grp-I.
IPR008068; Cyt_P450_E_grp-I_CYP2B-like.
Graphical view of domain structure.

Gene3D

G3DSA:1.10.630.10; Cyt_P450; 1.

PANTHER

PTHR19383; Cyt_P450; 1.

Pfam

PF00067; p450; 1.
Pfam graphical view of domain structure.

PRINTS

PR00463; EP450I.
PR01685; EP450ICYP2B.
PR00385; P450.

PROSITE

PS00086; CYTOCHROME_P450; 1.

Genome annotation databases

Ensembl

ENSMUSG00000042248; Mus musculus. [Contig view]

Phylogenomic databases

HOGENOM

P56654; -.

HOVERGEN

P56654; -.

Other

SOURCE

Cyp2c37; Mus musculus.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Endoplasmic reticulum; Heme; Iron; Membrane; Metal-binding; Microsome; Monooxygenase; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 490`	`490`	`Cytochrome P450 2C37.`	`PRO_0000051720`
`METAL`	`435 435`		`Iron (heme axial ligand) (By similarity).`

Sequence information

Length: 490 AA [This is the length of the unprocessed precursor]

Molecular weight: 55513 Da [This is the MW of the unprocessed precursor]

CRC64: 287A71D2D0BC7B5B [This is a checksum on the sequence]

        10         20         30         40         50         60 
MDPILVLVLT LSCLFLLSLW RQSSERGKLP PGPTPLPIIG NILQIDVKDI CQSFTNLSKV 

        70         80         90        100        110        120 
YGPVYTLYLG RKPTVVLHGY EAVKEALVDH GEEFAGRGRF PVFDKATNGM GLAFSKGNVW 

       130        140        150        160        170        180 
KNTRRFSLMT LRNLGMGKRS IEDRVQEEAR CLVEELRKTN GSPCDPTFIL GCAPCNVICS 

       190        200        210        220        230        240 
IIFQDRFDYK DRDFLNLMEK LNEITKILSS PWLQICNTYP ALLDYCPGSH KQFFKNYACI 

       250        260        270        280        290        300 
KNFLLEKIKE HEESLDVTIP RDFIDYFLIN GGQEDGNQPL QNRLEHLAIT VTDLFSAGTE 

       310        320        330        340        350        360 
TTSTTLRYAL LLLLKYPHVT AKVQKEIEHV IGKHRSPCMQ DRSRMPYTDA MIHEVQRFID 

       370        380        390        400        410        420 
LIPNSLPHEV TCDIKFRNYF IPKGTTVITS LSSVLHDSTE FPNPEVFDPG HFLDGNGKFK 

       430        440        450        460        470        480 
KSDYFMPFST GKRICAGEGL ARMELFLFLT SILQSFNLKP LVHPKDIDVT PMLIGLGSVP 

       490 
PAFQLCFIPS

P56654 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools