PROTEIN SEQUENCE.
TISSUE=Liver;
PubMed=7607249 [NCBI, ExPASy, EBI, Israel, Japan]
Taketani S., Yoshinaga T., Furukawa T., Kohno H., Tokunaga R., Nishimura K., Inokuchi H.;
"Induction of terminal enzymes for heme biosynthesis during differentiation of mouse erythroleukemia cells.";
Eur. J. Biochem. 230:760-765(1995).

Comments

FUNCTION: Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.
CATALYTIC ACTIVITY: Protoporphyrinogen-IX + 3 O₂ = protoporphyrin-IX + 3 H₂O₂.
COFACTOR: Binds 1 FAD per dimer (By similarity).
PATHWAY: Porphyrin metabolism; protoporphyrin-IX biosynthesis; protoporphyrin-IX from protoporphyrinogen-IX: step 1/1 .
SUBUNIT: Homodimer (By similarity).
SUBCELLULAR LOCATION: Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side (By similarity). Note=Bound to the mitochondrial inner membrane with its active site facing the cytosolic side (By similarity).
SIMILARITY: Belongs to the protoporphyrinogen oxidase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

PIR

S65629; S65629.

3D structure databases

ModBase

P56602.

Ontologies

GO:0005743;	Cellular component: mitochondrial inner membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0004729;	Molecular function: protoporphyrinogen oxidase activity (inferred from electronic annotation from EC).
GO:0006783;	Biological process: heme biosynthetic process (inferred from electronic annotation from UniProtKB-KW).
GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
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Family and domain databases

Genome annotation databases

Ensembl

ENSBTAG00000040500; Bos taurus. [Contig view]

Phylogenomic databases

HOVERGEN

P56602; -.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Direct protein sequencing; FAD; Flavoprotein; Heme biosynthesis; Membrane; Mitochondrion; Mitochondrion inner membrane; Oxidoreductase; Porphyrin biosynthesis.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`<1 >28`	`>28`	`Protoporphyrinogen oxidase.`	`PRO_0000135269`
`NON_CONS`	`13 14`
`NON_TER`	`1 1`
`NON_TER`	`28 28`

Sequence information

Length: 28 AA [This is the length of the partial sequence of the unprocessed precursor]

Molecular weight: 2777 Da [This is the MW of the partial sequence of the unprocessed precursor]

CRC64: FEDFC3F09CB6A345 [This is a checksum on the sequence]

        10         20 
GRTVVVLGGG ISGDSLCRGV FAGNSREL

P56602 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools