[1]	PROTEIN SEQUENCE. TISSUE=Heart; DOI=10.1021/bi00488a010; PubMed=2252888 [NCBI, ExPASy, EBI, Israel, Japan] Huang Y.C., Colman R.F.; "Subunit location and sequences of the cysteinyl peptides of pig heart NAD-dependent isocitrate dehydrogenase."; Biochemistry 29:8266-8273(1990).

Comments

CATALYTIC ACTIVITY: Isocitrate + NAD⁺ = 2-oxoglutarate + CO₂ + NADH.
SUBUNIT: Heterooligomer of subunits alpha, beta, and gamma in the apparent ratio of 2:1:1.
SUBCELLULAR LOCATION: Mitochondrion.
SIMILARITY: Belongs to the isocitrate and isopropylmalate dehydrogenases family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

PIR

B35834; B35834.

3D structure databases

ModBase

P56472.

Ontologies

GO:0005739;	Cellular component: mitochondrion (inferred from electronic annotation from UniProtKB-KW).
GO:0004449;	Molecular function: isocitrate dehydrogenase (NAD+) activity (inferred from electronic annotation from EC).
GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0006099;	Biological process: tricarboxylic acid cycle (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR001804; IsoCit_IM_DHase.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.718.10; IDH_IMDH; 1.

PANTHER

PTHR11835; IDH_IMDH_dimeric; 1.

PROSITE

PS00470; IDH_IMDH; PARTIAL.

Phylogenomic databases

HOVERGEN

P56472; -.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Direct protein sequencing; Mitochondrion; NAD; Oxidoreductase; Tricarboxylic acid cycle.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 103`	`103`	`Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial.`	`PRO_0000083591`
`NON_CONS`	`33 34`
`NON_CONS`	`40 41`
`NON_CONS`	`59 60`
`NON_CONS`	`79 80`

Sequence information

Length: 103 AA [This is the length of the partial sequence of the unprocessed precursor]

Molecular weight: 10803 Da [This is the MW of the partial sequence of the unprocessed precursor]

CRC64: 83D811D29EA7756B [This is a checksum on the sequence]

        10         20         30         40         50         60 
ASRSQAEDVR VEGAFPVTML PGDGVGPELM AAVGVIECLK LGDGLFLQCC EEVAELYPKN 

        70         80         90        100 
IANPTATLLA SCMMLDHLKT SDMGGYATCQ DFTEAVIGAL SHP

P56472 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools