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UniProtKB/Swiss-Prot entry P56429


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DHOM_HELPY
Primary accession number P56429
Secondary accession numbers None
Integrated into Swiss-Prot on July 15, 1998
Sequence was last modified on July 15, 1998 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 53)
Name and origin of the protein
Protein name Homoserine dehydrogenase
Synonyms HDH
EC 1.1.1.3
Gene name
Name: hom
OrderedLocusNames: HP_0822
From
Helicobacter pylori (Campylobacter pylori) [TaxID: 210] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales; Helicobacteraceae; Helicobacter.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 700392 / 26695;
DOI=10.1038/41483; PubMed=9252185 [NCBI, ExPASy, EBI, Israel, Japan]
Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.;
"The complete genome sequence of the gastric pathogen Helicobacter pylori.";
Nature 388:539-547(1997).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE000511; AAD07869.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR F64622; F64622.
RefSeq NP_207615.1; -.
3D structure databases
ModBase P56429.
Protein-protein interaction databases
DIP DIP:3530N; -.
Family and domain databases
InterPro IPR002912; ACT_bd.
IPR005106; Asp/hSer_DHase_NAD-bd.
IPR016204; hSer_DHase.
IPR001342; hSer_DHase_cat.
Graphical view of domain structure.
Pfam PF01842; ACT; 1.
PF00742; Homoserine_dh; 1.
PF03447; NAD_binding_3; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000098; Homoser_dehydrog; 1.
PROSITE PS01042; HOMOSER_DHGENASE; 1.
BLOCKS P56429.
Genome annotation databases
GeneID 898826; -.
GenomeReviews AE000511_GR; HP_0822.
KEGG hpy:HP0822; -.
NMPDR fig|85962.1.peg.813; -.
TIGR HP_0822; -.
Phylogenomic databases
HOGENOM P56429; -.
Other
ProtoNet P56429.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Branched-chain amino acid biosynthesis; Complete proteome; Isoleucine biosynthesis; Methionine biosynthesis; NADP; Oxidoreductase; Threonine biosynthesis.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   421  421     Homoserine dehydrogenase. PRO_0000066694
DOMAIN   342   419  78     ACT. 
NP_BIND   10    17  8     NADP (By similarity). 
ACT_SITE   201   201        Proton donor (Potential). 
BINDING   103   103        NADP (By similarity). 
BINDING   186   186        Substrate (By similarity). 
Sequence information
Length: 421 AA [This is the length of the unprocessed precursor] Molecular weight: 46168 Da [This is the MW of the unprocessed precursor] CRC64: 1C10A8C37D2C975B [This is a checksum on the sequence]
        10         20         30         40         50         60 
MKKRLNIGLV GLGCVGSAVA KILQENQEII KDRAGVGIGI KKAVVRDVKK HKGYPFEISN 

        70         80         90        100        110        120 
DLESLIEDEE IDIVVELMGG VEAPYLLAKK TLAKQKAFVT ANKAMLAYHR YELEQTAKNT 

       130        140        150        160        170        180 
PIGFEASVCG GIPIIKALKD GLSANHILSF KGILNGTSNY ILSQMFKNQA SFKDALKDAQ 

       190        200        210        220        230        240 
HLGYAELNPE FDIKGIDAAH KLLILASLAY GIDAKLEEIL IEGIEKIEPD DMEFAKEFGY 

       250        260        270        280        290        300 
SIKLLGIAKK HPDCIELRVH PSMIKNECML SKVDGVMNAI SVIGDKVGET LYYGAGAGGE 

       310        320        330        340        350        360 
PTASAVISDI IEIARKKSSL MLGFETPQKL PLKPKEEIQC AYYARLLVSD EKGVFSQISA 

       370        380        390        400        410        420 
ILAQNDISLN NVLQKEILHS NKAKILFSTH TTNEKSMLNA LKELENLQSV LDTPKMIRLE 


N 

P56429 in FASTA format

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