NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT).
PubMed=7731712 [NCBI, ExPASy, EBI, Israel, Japan]
Valenzuela D.M., Rojas E., Griffiths J.A., Compton D.L., Gisser M., Ip N.Y., Goldfarb M., Yancopoulos G.D.;
"Identification of full-length and truncated forms of Ehk-3, a novel member of the Eph receptor tyrosine kinase family.";
Oncogene 10:1573-1580(1995).

Comments

FUNCTION: Receptor for members of the ephrin-A family. Binds to ephrin-A1, -A2, -A3, -A4 and -A5.
CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
SUBUNIT: Interacts with PRKCABP and GRIP1 (By similarity).
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.

ALTERNATIVE PRODUCTS: 2 named isoforms [FASTA] produced by alternative splicing.

Name	Long
Isoform ID	P54759-1
Note: More widely expressed in the embryo.
This is the isoform sequence displayed in this entry.

Name	Short
Isoform ID	P54759-2
Note: Lacks the kinase domain.
Features which should be applied to build the isoform sequence: VSP_003012.

TISSUE SPECIFICITY: Restricted to the nervous system.
SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
SIMILARITY: Contains 2 fibronectin type-III domains.
SIMILARITY: Contains 1 protein kinase domain.
SIMILARITY: Contains 1 SAM (sterile alpha motif) domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

U21954; AAA86830.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
U21955; AAA86831.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_599158.1; -.

UniGene

Rn.10181

3D structure databases

HSSP

P54763; 1JPA. [HSSP ENTRY / PDB]

SMR

P54759; 613-901.

ModBase

P54759.

Protein-protein interaction databases

IntAct

P54759; -.

PTM databases

PhosphoSite

P54759; -.

Organism-specific databases

RGD

70957; Epha7.

Gene expression databases

ArrayExpress

P54759; -.

GermOnline

ENSRNOG00000007030; Rattus norvegicus.

Ontologies

GO:0005515;	Molecular function: protein binding (inferred from physical interaction from UniProtKB).
GO:0004713;	Molecular function: protein tyrosine kinase activity (inferred from direct assay from UniProtKB).
GO:0016310;	Biological process: phosphorylation (inferred from direct assay from UniProtKB).
QuickGo view.

Family and domain databases

InterPro

IPR013032; EGF_like_reg_CS.
IPR001090; Eph_rcpt_lig_bd.
IPR008957; Fibronectin_typ-III-like_fold.
IPR003961; FN_III.
IPR003962; FnIII_subd.
IPR000719; Prot_kinase_core.
IPR017441; Protein_kinase_ATP_bd_CS.
IPR001660; SAM.
IPR013761; SAM_type.
IPR001245; Tyr_pkinase.
IPR008266; Tyr_pkinase_AS.
IPR016257; TyrPK_ephrin_receptor.
IPR001426; YKase_receptorV_CS.
Graphical view of domain structure.

Gene3D

G3DSA:2.60.40.30; FN_III-like; 2.
G3DSA:1.10.150.50; SAM_type; 1.

Pfam

PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07714; Pkinase_Tyr; 1.
PF00536; SAM_1; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF000666; TyrPK_ephrin_receptor; 1.

PRINTS

PR00014; FNTYPEIII.
PR00109; TYRKINASE.

ProDom

PD001495; Ephrin_receptor; 1.
PD000001; Prot_kinase; 1.
[Domain structure / List of seq. sharing at least 1 domain]

SMART

SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
SMART graphical view of domain structure.

PROSITE

PS01186; EGF_2; UNKNOWN_1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
PROSITE graphical view of domain structure (profiles).

Genome annotation databases

Ensembl

ENSRNOG00000007030; Rattus norvegicus. [Contig view]

GeneID

171287; -.

KEGG

rno:171287; -.

Phylogenomic databases

HOVERGEN

P54759; -.

Other

NextBio

622031; -.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Alternative splicing; ATP-binding; Glycoprotein; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Repeat; Signal; Transferase; Transmembrane; Tyrosine-protein kinase.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 24`	`24`	`Potential.`
`CHAIN`	`25 998`	`974`	`Ephrin type-A receptor 7.`	`PRO_0000016820`
`TOPO_DOM`	`25 556`	`532`	`Extracellular (Potential).`
`TRANSMEM`	`557 577`	`21`	`Potential.`
`TOPO_DOM`	`578 998`	`421`	`Cytoplasmic (Potential).`
`DOMAIN`	`331 433`	`103`	`Fibronectin type-III 1.`
`DOMAIN`	`443 535`	`93`	`Fibronectin type-III 2.`
`DOMAIN`	`633 894`	`262`	`Protein kinase.`
`DOMAIN`	`923 987`	`65`	`SAM.`
`NP_BIND`	`639 647`	`9`	`ATP (By similarity).`
`MOTIF`	`996 998`	`3`	`PDZ-binding (Potential).`
`COMPBIAS`	`192 328`	`137`	`Cys-rich.`
`ACT_SITE`	`758 758`		`Proton acceptor (By similarity).`
`BINDING`	`665 665`		`ATP (By similarity).`
`MOD_RES`	`608 608`		`Phosphotyrosine; by autocatalysis (Potential).`
`MOD_RES`	`614 614`		`Phosphotyrosine; by autocatalysis (Potential).`
`MOD_RES`	`791 791`		`Phosphotyrosine; by autocatalysis (Potential).`
`MOD_RES`	`940 940`		`Phosphotyrosine; by autocatalysis (Potential).`
`CARBOHYD`	`343 343`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`410 410`		`N-linked (GlcNAc...) (Potential).`
`VAR_SEQ`	`600 610`		`FKFPGTKTYID -> SLVTNEHLSVL (in isoform Short).`	`VSP_003012`

Sequence information

Length: 998 AA [This is the length of the unprocessed precursor]

Molecular weight: 111953 Da [This is the MW of the unprocessed precursor]

CRC64: A7A82A698924876C [This is a checksum on the sequence]

        10         20         30         40         50         60 
MVVQTRYPSW IILCYIWLLG FAHTGEAQAA KEVLLLDSKA QQTELEWISS PPSGWEEISG 

        70         80         90        100        110        120 
LDENYTPIRT YQVCQVMEPN QNNWLRTNWI SKGNAQRIFV ELKFTLRDCN SLPGVLGTCK 

       130        140        150        160        170        180 
ETFNLYYYET DYDTGRNIRE NLYVKIDTIA ADESFTQGDL GERKMKLNTE VREIGPLSKK 

       190        200        210        220        230        240 
GFYLAFQDVG ACIALVSVKV YYKKCWSIIE NLAVFPDTVT GSEFSSLVEV RGTCVSSAEE 

       250        260        270        280        290        300 
EAENSPRMHC SAEGEWLVPI GKCICKAGYQ QKGDTCEPCG RRFYKSSSQD LQCSRCPTHS 

       310        320        330        340        350        360 
FSDREGSSRC ECEDGYYRAP SDPPYVACTR PPSAPQNLIF NINQTTVSLE WSPPADNGGR 

       370        380        390        400        410        420 
NDVTYRILCK RCSWEQGECV PCGSNIGYMP QQTGLEDNYV TVMDLLAHAN YTFEVEAVNG 

       430        440        450        460        470        480 
VSDLSRSQRL FAAVSITTGQ AAPSQVSGVM KERVLQRSVE LSWQEPEHPN GVITEYEIKY 

       490        500        510        520        530        540 
YEKDQRERTY STLKTKSTSA SINNLKPGTV YVFQIRAFTA AGYGNYSPRL DVATLEEASG 

       550        560        570        580        590        600 
KMFEATAVSS EQNPVIIIAV VAVAGTIILV FMVFGFIIGR RHCGYSKADQ EGDEELYFHF 

       610        620        630        640        650        660 
KFPGTKTYID PETYEDPNRA VHQFAKELDA SCIKIERVIG AGEFGEVCSG RLKLPGKRDV 

       670        680        690        700        710        720 
AVAIKTLKVG YTEKQRRDFL CEASIMGQFD HPNVVHLEGV VTRGKPVMIV IEFMENGALD 

       730        740        750        760        770        780 
AFLRKHDGQF TVIQLVGMLR GIAAGMRYLA DMGYVHRDLA ARNILVNSNL VCKVSDFGLS 

       790        800        810        820        830        840 
RVIEDDPEAV YTTTGGKIPV RWTAPEAIQY RKFTSASDVW SYGIVMWEVM SYGERPYWDM 

       850        860        870        880        890        900 
SNQDVIKAIE EGYRLPAPMD CPAGLHQLML DCWQKERAER PKFEQIVGIL DKMIRNPSSL 

       910        920        930        940        950        960 
KTPLGTCSRP ISPLLDQSTP DFTAFCSVGE WLQAIKMERY KDNFTAAGYN SLESVARMTI 

       970        980        990 
DDVMSLGITL VGHQKKIMSS IQTMRAQMLH LHGTGIQV

P54759 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools