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UniProtKB/Swiss-Prot entry P52986

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DHOM_SYNY3
Primary accession number P52986
Secondary accession numbers None
Integrated into Swiss-Prot on October 1, 1996
Sequence was last modified on October 1, 1996 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 50)
Name and origin of the protein
Protein name Homoserine dehydrogenase
Synonyms HDH
EC 1.1.1.3
Gene name
Name: hom
OrderedLocusNames: sll0455
From
Synechocystis sp. (strain PCC 6803) [TaxID: 1148] [HAMAP proteome]
Taxonomy Bacteria; Cyanobacteria; Chroococcales; Synechocystis.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1093/dnares/2.4.153; PubMed=8590279 [NCBI, ExPASy, EBI, Israel, Japan]
Kaneko T., Tanaka A., Sato S., Kotani H., Sazuka T., Miyajima N., Sugiura M., Tabata S.;
"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. I. Sequence features in the 1 Mb region from map positions 64% to 92% of the genome.";
DNA Res. 2:153-166(1995).
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1093/dnares/3.3.109; PubMed=8905231 [NCBI, ExPASy, EBI, Israel, Japan]
Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.;
"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions.";
DNA Res. 3:109-136(1996).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BA000022; BAA10325.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S74407; S74407.
RefSeq NP_442255.1; -.
3D structure databases
ModBase P52986.
Enzyme and pathway databases
BioCyc SSP1148:SLL0455-MON; -.
Family and domain databases
InterPro IPR002912; ACT_bd.
IPR005106; Asp/hSer_DHase_NAD-bd.
IPR016204; hSer_DHase.
IPR001342; hSer_DHase_cat.
Graphical view of domain structure.
Pfam PF01842; ACT; 1.
PF00742; Homoserine_dh; 1.
PF03447; NAD_binding_3; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000098; Homoser_dehydrog; 1.
PROSITE PS01042; HOMOSER_DHGENASE; 1.
BLOCKS P52986.
Genome annotation databases
GeneID 952451; -.
GenomeReviews BA000022_GR; sll0455.
KEGG syn:sll0455; -.
NMPDR fig|1148.1.peg.2356; -.
Phylogenomic databases
HOGENOM P52986; -.
Genome annotation databases
CMR P52986; sll0455.
Other
ProtoNet P52986.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Branched-chain amino acid biosynthesis; Complete proteome; Isoleucine biosynthesis; Methionine biosynthesis; NADP; Oxidoreductase; Threonine biosynthesis.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   433  433     Homoserine dehydrogenase. PRO_0000066704
DOMAIN   355   428  74     ACT. 
NP_BIND   8    15  8     NADP (By similarity). 
ACT_SITE   202   202        Proton donor (Potential). 
BINDING   102   102        NADP (By similarity). 
BINDING   187   187        Substrate (By similarity). 
Sequence information
Length: 433 AA [This is the length of the unprocessed precursor] Molecular weight: 45486 Da [This is the MW of the unprocessed precursor] CRC64: 4A7A034A7D2766B5 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MTVKIGLLGL GTVGSGTVEI LQDPQGRSPL LKAIEVKAVG VRSLDKPRQV NLPPEVLTTD 

        70         80         90        100        110        120 
LEAIVTDPDI AIVVELMGGL EPARSLILQA IAHKKHIVTA NKAVIARYGP EIYEAANQHG 

       130        140        150        160        170        180 
VYVLLEAAVG GGIPIIKPLK QSLGGNRIQS IVGILNGTTN YILSRMTSEG ADFDEVLTAA 

       190        200        210        220        230        240 
QQLGYAEADP SADVDGLDAA DKIAILASLG FGGRVKREDV ACEGIRSVSA VDIAYADRLG 

       250        260        270        280        290        300 
FVIKLLAIAD GNAGEDSEAL QLRVHPTLIA KDHPLASVNG VYNGVLVTGD PLGQVMFYGR 

       310        320        330        340        350        360 
GAGAGPTASA VVSDVINIVG IITSSDENPA LDPLLSCTHQ HYCQVSPIED LVTRFYCRFL 

       370        380        390        400        410        420 
CADVPGVIGH LGMGFGNHGV SLESLVQIGF TDGCAEIVVV THDVREGDYR AALEEISQLE 

       430 
AVKEIPSVIR VLS
P52986 in FASTA format

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