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[1]
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NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
TISSUE=Brain;
PubMed=2495531 [NCBI, ExPASy, EBI, Israel, Japan]
Kirchhausen T.,
Nathanson K.L.,
Matsui W.,
Vaisberg A.,
Chow E.P.,
Burne C.,
Keen J.H.,
Davis A.E.;
"Structural and functional division into two domains of the large (100- to 115-kDa) chains of the clathrin-associated protein complex AP-2.";
Proc. Natl. Acad. Sci. U.S.A. 86:2612-2616(1989).
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[2]
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CHARACTERIZATION OF ISOFORMS A AND B.
DOI=10.1093/hmg/3.8.1393; PubMed=7987321 [NCBI, ExPASy, EBI, Israel, Japan]
Peyrard M.,
Fransson I.,
Xie Y.-G.,
Han F.-Y.,
Ruttledge M.H.,
Swahn S.,
Collins J.E.,
Dunham I.,
Collins V.P.,
Dumanski J.P.;
"Characterization of a new member of the human beta-adaptin gene family from chromosome 22q12, a candidate meningioma gene.";
Hum. Mol. Genet. 3:1393-1399(1994).
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[3]
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X-RAY CRYSTALLOGRAPHY (4.0 ANGSTROMS) OF 1-584, AND SUBUNIT.
DOI=10.1073/pnas.0406102101; PubMed=15377783 [NCBI, ExPASy, EBI, Israel, Japan]
Heldwein E.E.,
Macia E.,
Wang J.,
Yin H.L.,
Kirchhausen T.,
Harrison S.C.;
"Crystal structure of the clathrin adaptor protein 1 core.";
Proc. Natl. Acad. Sci. U.S.A. 101:14108-14113(2004).
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- FUNCTION: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
- SUBUNIT: Adaptor protein complex 1 (AP-1) is an heterotetramer composed of two large adaptins (gamma-type subunit AP1G1 and beta-type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or AP1M2) and a small adaptin (sigma-type subunit AP1S1 or AP1S2 or AP1S3).
- SUBCELLULAR LOCATION: Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.
- ALTERNATIVE PRODUCTS:
2 named isoforms [FASTA] produced by alternative splicing.
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| Name | B |
| Isoform ID | P52303-2 |
| Features which should be applied to build the isoform sequence: VSP_000164. |
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- PTM: The N-terminus is blocked.
- SIMILARITY: Belongs to the adaptor complexes large subunit family.
- CAUTION: Was originally (PubMed:2495531) thought to be part of the complex AP-2.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 949 AA [This is the length of the unprocessed precursor] |
Molecular weight: 104589 Da [This is the MW of the unprocessed precursor] |
CRC64: CC5AE54E8AACCD44 [This is a checksum on the sequence] |
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10 20 30 40 50 60
MTDSKYFTTT KKGEIFELKA ELNSDKKEKK KEAVKKVIAS MTVGKDVSAL FPDVVNCMQT
70 80 90 100 110 120
DNLELKKLVY LYLMNYAKSQ PDMAIMAVNT FVKDCEDPNP LIRALAVRTM GCIRVDKITE
130 140 150 160 170 180
YLCEPLRKCL KDEDPYVRKT AAVCVAKLHD INAQLVEDQG FLDTLKDLIS DSNPMVVANR
190 200 210 220 230 240
VAALSEIAES HPSSNLLDLK AQSINKLLTA LNECTEWAQI FILDCLGNYM PKDDREAQSI
250 260 270 280 290 300
CERVTPRLSH ANSAVVLSAV KVLMKFMEML SKDLDYYATL LKKLAPPLVT LLSAEPEPQY
310 320 330 340 350 360
VPLRNINLIV QKRPEILKHE MKVFFVKYND PIYVKLEKLD IMIRLASQAN IAQVLAELKE
370 380 390 400 410 420
YATEVDVDFV RKAVRAIGRC AIKVEQSAER CVSTLLDLIQ TKVNYVVQEA IVVIKDIFRK
430 440 450 460 470 480
YPNKYESVIA TLCENLDSLD EPEARAAMIW IVGEYAERID NADELLESFL DGFHDESTQV
490 500 510 520 530 540
QLQLLTAIVK LFLKKPTETQ ELVQQVLSLA TQDSDNPDLR DRGYIYWRLL STDPVAAKEV
550 560 570 580 590 600
VLAEKPLISE ETDLIEPTLL DELICYIGTL ASVYHKPPNA FVEGGRGVVH KSLPPRTASS
610 620 630 640 650 660
ESTESPEAAP AGAPASDQPD VIPAQGDLLG DLLNLDLGPP VSGPPLAASS VQMGAVDLLG
670 680 690 700 710 720
GGLDSLMGDE PEGIGDSNFG APPASVAAAA PARLGAPVSS GLSDLFDLTS GVGTLSGSYV
730 740 750 760 770 780
APKAVWLPAM KAKGLEISGT FTRQVGSISM DLQLTNKALQ VMTDFAIQFN RNSFGLAPAA
790 800 810 820 830 840
PLQVHAPLSP NQTVEISLPL NTVGSVMKME PLNNLQVAVK NNIDVFYFST LYPLHVLFVE
850 860 870 880 890 900
DGKMDRQMFL ATWKDIPNEN EAQFQIRDCP LNTEAASSKL QSSNIFTVAK RTVEGQDMLY
910 920 930 940
QSLKLTNGIW VLAELRIQPG NPSFTLSLKC RAPEVSQHDI QAYETILKN
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P52303 in FASTA format |
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