[1]	NUCLEOTIDE SEQUENCE [MRNA]. DOI=10.1007/s004270050320; PubMed=11180838 [NCBI, ExPASy, EBI, Israel, Japan] Onuma Y., Nishihara R., Takahashi S., Tanegashima K., Fukui A., Asashima M.; "Expression of the Xenopus GTP-binding protein gene Ran during embryogenesis."; Dev. Genes Evol. 210:325-327(2000).
[2]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. TISSUE=Embryo; NIH - Xenopus Gene Collection (XGC) project; Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
[3]	PROTEIN SEQUENCE OF 40-52 AND 62-71. TISSUE=Ovary; DOI=10.1038/365661a0; PubMed=8413630 [NCBI, ExPASy, EBI, Israel, Japan] Moore M.S., Blobel G.; "The GTP-binding protein Ran/TC4 is required for protein import into the nucleus."; Nature 365:661-663(1993).

Comments

FUNCTION: GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity).
SUBCELLULAR LOCATION: Nucleus.
SIMILARITY: Belongs to the small GTPase superfamily. Ran family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AB030945; BAA89696.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC041293; AAH41293.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_001080182.1; -.
NP_001128547.1; -.

UniGene

Xl.55052

3D structure databases

HSSP

P17080; 1RRP. [HSSP ENTRY / PDB]

SMR

P52301; 2-216.

ModBase

P52301.

Organism-specific databases

Xenbase

XB-FEAT-489467; ran.

Ontologies

GO:0005634;	Cellular component: nucleus (inferred from electronic annotation from UniProtKB-SubCell).
GO:0005525;	Molecular function: GTP binding (inferred from electronic annotation from UniProtKB-KW).
GO:0003924;	Molecular function: GTPase activity (inferred from electronic annotation from InterPro).
GO:0005515;	Molecular function: protein binding (inferred from electronic annotation from InterPro).
GO:0006886;	Biological process: intracellular protein transport (inferred from electronic annotation from InterPro).
GO:0006913;	Biological process: nucleocytoplasmic transport (inferred from electronic annotation from InterPro).
GO:0007165;	Biological process: signal transduction (inferred from electronic annotation from InterPro).
QuickGo view.

Family and domain databases

InterPro

IPR018210; GTP-bd_nuclear_protein_CS.
IPR002041; Ran_GTPase.
IPR013753; Ras.
IPR005225; Small_GTP_bd.
Graphical view of domain structure.

Pfam

PF00071; Ras; 1.
Pfam graphical view of domain structure.

PRINTS

PR00627; GTPRANTC4.

SMART

SM00176; RAN; 1.
SMART graphical view of domain structure.

TIGRFAMs

TIGR00231; small_GTP; 1.

PROSITE

PS51418; RAN; 1.
PROSITE graphical view of domain structure (profiles).

Genome annotation databases

GeneID

100189578; -.
379874; -.

KEGG

xla:100189578; -.
xla:379874; -.

Phylogenomic databases

HOVERGEN

P52301; -.

Other

ProtoNet

P52301.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Direct protein sequencing; GTP-binding; Nucleotide-binding; Nucleus; Protein transport; Transport.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 216`	`216`	`GTP-binding nuclear protein Ran.`	`PRO_0000208702`
`NP_BIND`	`17 24`	`8`	`GTP (By similarity).`
`NP_BIND`	`65 69`	`5`	`GTP (By similarity).`
`NP_BIND`	`122 125`	`4`	`GTP (By similarity).`
`CONFLICT`	`199 199`		`Q -> A (in Ref. 2; AAH41293).`

Sequence information

Length: 216 AA [This is the length of the unprocessed precursor]

Molecular weight: 24398 Da [This is the MW of the unprocessed precursor]

CRC64: D5DB10D65C2AD5A4 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MAAQGEPQVQ FKLVLVGDGG TGKTTFVKRH LTGEFEKKYV ATLGVEVHPL VFHTNRGPIK 

        70         80         90        100        110        120 
FNVWDTAGQE KFGGLRDGYY IQAQCAIIMF DVTSRVTYKN VPNWHRDLVR VCENIPIVLC 

       130        140        150        160        170        180 
GNKVDIKDRK VKAKSIVFHR KKNLQYYDIS AKSNYNFEKP FLWLARKLIG DPNLEFVAMP 

       190        200        210 
ALAPPEVVMD PALAAQYEQD LQNAQATALP DEDDDL

P52301 in FASTA format

View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools