[1]	PROTEIN SEQUENCE. TISSUE=Egg; DOI=10.1016/S0960-9822(95)00079-0; PubMed=7627554 [NCBI, ExPASy, EBI, Israel, Japan] Goerlich D., Kostka S., Kraft R., Dingwall C., Laskey R.A., Hartmann E., Prehn S.; "Two different subunits of importin cooperate to recognize nuclear localization signals and bind them to the nuclear envelope."; Curr. Biol. 5:383-392(1995).
[2]	PROTEIN SEQUENCE OF 54-69 AND 85-107. TISSUE=Ovary; DOI=10.1073/pnas.92.5.1769; PubMed=7878057 [NCBI, ExPASy, EBI, Israel, Japan] Radu A., Blobel G., Moore M.M.; "Identification of a protein complex that is required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins."; Proc. Natl. Acad. Sci. U.S.A. 92:1769-1773(1995).

Comments

FUNCTION: Required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins.
SUBUNIT: Forms a complex with an importin alpha subunit.
INTERACTION:
Q7ZZY7:Rae1/Gle2; NbExp=3; IntAct=EBI-618940, EBI-618949;
SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus envelope (By similarity).
SIMILARITY: Belongs to the importin beta family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

3D structure databases

HSSP

Q14974; 1IBR. [HSSP ENTRY / PDB]

SMR

P52297; 1-69.

ModBase

P52297.

Protein-protein interaction databases

IntAct

P52297; 1.

Ontologies

GO:0005737;	Cellular component: cytoplasm (inferred from electronic annotation from UniProtKB-SubCell).
GO:0005635;	Cellular component: nuclear envelope (inferred from electronic annotation from UniProtKB-SubCell).
GO:0005515;	Molecular function: protein binding (inferred from physical interaction from IntAct).
GO:0015031;	Biological process: protein transport (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR011989; ARM-like.
Graphical view of domain structure.

Gene3D

G3DSA:1.25.10.10; ARM-like; 1.

Phylogenomic databases

HOVERGEN

P52297; -.

Other

ProtoNet

P52297.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cytoplasm; Direct protein sequencing; Nucleus; Protein transport; Repeat; Transport.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 >260`	`>260`	`Importin subunit beta.`	`PRO_0000120761`
`CONFLICT`	`65 65`		`R -> P (in Ref. 1; AA sequence).`
`NON_CONS`	`17 18`
`NON_CONS`	`49 50`
`NON_CONS`	`69 70`
`NON_CONS`	`84 85`
`NON_CONS`	`107 108`
`NON_CONS`	`126 127`
`NON_CONS`	`131 132`
`NON_CONS`	`136 137`
`NON_CONS`	`141 142`
`NON_CONS`	`147 148`
`NON_CONS`	`163 164`
`NON_CONS`	`183 184`
`NON_CONS`	`195 196`
`NON_CONS`	`205 206`
`NON_CONS`	`210 211`
`NON_CONS`	`220 221`
`NON_CONS`	`234 235`
`NON_CONS`	`240 241`
`NON_CONS`	`248 249`
`NON_TER`	`260 260`

Sequence information

Length: 260 AA [This is the length of the partial sequence of the unprocessed precursor]

Molecular weight: 28977 Da [This is the MW of the partial sequence of the unprocessed precursor]

CRC64: F66FC8888E27292C [This is a checksum on the sequence]

        10         20         30         40         50         60 
ELVTILEKTV SPDRRXLKFL EQAAVENLPT FVVELSKVLA NPANSQVARK AQYQQRWLAI 

        70         80         90        100        110        120 
DANARGEIKK ESXLEAIDYI XQDIEEPSNN VRLAATNALL NSLEFTKDLA IEASEAAEQG 

       130        140        150        160        170        180 
XPPEXTKFYE KKEHIKRYAA VKDPSVVKLL ETTDRPDGHQ NNLDVVMASL LXMFQXTAGS 

       190        200        210        220        230        240 
GGVQFLLENL GNEXVLAIGG EFXXYKGDYD KGDQENVHPD XVQPRVERIX SFXDKLVEAR 

       250        260 
IHELLTEGKT LATXATKEDV

P52297 in FASTA format

View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools