[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. STRAIN=Nine Mile; DOI=10.1016/0378-1119(94)00888-Y; PubMed=7698664 [NCBI, ExPASy, EBI, Israel, Japan] Heinzen R.A., Mo Y.-Y., Robertson S.J., Mallavia L.P.; "Characterization of the succinate dehydrogenase-encoding gene cluster (sdh) from the rickettsia Coxiella burnetii."; Gene 155:27-34(1995).
[2]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. STRAIN=Nine Mile; Thiele D., Willems H., Oswald W., Krauss H.; Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases.
[3]	NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. STRAIN=Nine Mile phase I / RSA 493; DOI=10.1073/pnas.0931379100; PubMed=12704232 [NCBI, ExPASy, EBI, Israel, Japan] Seshadri R., Paulsen I.T., Eisen J.A., Read T.D., Nelson K.E., Nelson W.C., Ward N.L., Tettelin H., Davidsen T.M., Beanan M.J., DeBoy R.T., Daugherty S.C., Brinkac L.M., Madupu R., Dodson R.J., Khouri H.M., Lee K.H., Carty H.A., Scanlan D., Heinzen R.A., Thompson H.A., Samuel J.E., Fraser C.M., Heidelberg J.F.; "Complete genome sequence of the Q-fever pathogen, Coxiella burnetii."; Proc. Natl. Acad. Sci. U.S.A. 100:5455-5460(2003).

Comments

CATALYTIC ACTIVITY: Succinate + acceptor = fumarate + reduced acceptor.
COFACTOR: Binds 1 2Fe-2S cluster.
COFACTOR: Binds 1 3Fe-4S cluster.
COFACTOR: Binds 1 4Fe-4S cluster.
PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle .
SUBUNIT: Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur protein, cytochrome b-556 and a hydrophobic protein.
SIMILARITY: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
SIMILARITY: Contains 1 4Fe-4S ferredoxin-type domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

L33409; AAA74134.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
X77919; CAA54873.1; ALT_INIT; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AE016828; AAO90899.1; ALT_INIT; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

S42873; S42873.

RefSeq

NP_820385.1; -.

3D structure databases

HSSP

P07014; 1NEK. [HSSP ENTRY / PDB]

ModBase

P51053.

Enzyme and pathway databases

BioCyc

CBUR227377:CBU_1400-MON; -.

Ontologies

GO:0051537;	Molecular function: 2 iron, 2 sulfur cluster binding (inferred from electronic annotation from UniProtKB-KW).
GO:0051538;	Molecular function: 3 iron, 4 sulfur cluster binding (inferred from electronic annotation from UniProtKB-KW).
GO:0051539;	Molecular function: 4 iron, 4 sulfur cluster binding (inferred from electronic annotation from UniProtKB-KW).
GO:0005506;	Molecular function: iron ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0000104;	Molecular function: succinate dehydrogenase activity (inferred from electronic annotation from EC).
GO:0022900;	Biological process: electron transport chain (inferred from electronic annotation from UniProtKB-KW).
GO:0006810;	Biological process: transport (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR001450; 4Fe4S_Fe_S_bd.
IPR014979; Acetone_carboxylase_gsu-rel.
IPR012675; b-grasp_ferredoxin-like.
IPR001041; Ferredoxin.
IPR012285; Fum_reductase_C.
IPR004489; Succ_DHase/fum_Rdtase_Fe-S.
Graphical view of domain structure.

Gene3D

G3DSA:3.10.20.30; Ferredoxin_fold; 1.
G3DSA:1.10.1060.10; Fum_reductase_C; 1.

Pfam

PF08882; Acetone_carb_G; 1.
PF00111; Fer2; 1.
Pfam graphical view of domain structure.

TIGRFAMs

TIGR00384; dhsB; 1.

PROSITE

PS00198; 4FE4S_FER_1; 1.
PS51379; 4FE4S_FER_2; 1.
PROSITE graphical view of domain structure (profiles).

Genome annotation databases

GeneID

1209306; -.

GenomeReviews

AE016828_GR; CBU_1400.

KEGG

cbu:CBU_1400; -.

NMPDR

fig|227377.1.peg.1329; -.

TIGR

CBU_1400; -.

Phylogenomic databases

HOGENOM

P51053; -.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

2Fe-2S; 3Fe-4S; 4Fe-4S; Complete proteome; Electron transport; Iron; Iron-sulfur; Metal-binding; Oxidoreductase; Transport; Tricarboxylic acid cycle.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 235`	`235`	`Succinate dehydrogenase iron-sulfur subunit.`	`PRO_0000158687`
`DOMAIN`	`133 163`	`31`	`4Fe-4S ferredoxin-type.`
`METAL`	`53 53`		`Iron-sulfur 1 (2Fe-2S) (By similarity).`
`METAL`	`58 58`		`Iron-sulfur 1 (2Fe-2S) (By similarity).`
`METAL`	`61 61`		`Iron-sulfur 1 (2Fe-2S) (Potential).`
`METAL`	`73 73`		`Iron-sulfur 1 (2Fe-2S) (By similarity).`
`METAL`	`143 143`		`Iron-sulfur 2 (4Fe-4S) (By similarity).`
`METAL`	`146 146`		`Iron-sulfur 2 (4Fe-4S) (By similarity).`
`METAL`	`149 149`		`Iron-sulfur 2 (4Fe-4S) (By similarity).`
`METAL`	`153 153`		`Iron-sulfur 3 (3Fe-4S) (By similarity).`
`METAL`	`200 200`		`Iron-sulfur 3 (3Fe-4S) (By similarity).`
`METAL`	`206 206`		`Iron-sulfur 3 (3Fe-4S) (By similarity).`
`METAL`	`210 210`		`Iron-sulfur 2 (4Fe-4S) (By similarity).`

Sequence information

Length: 235 AA [This is the length of the unprocessed precursor]

Molecular weight: 26847 Da [This is the MW of the unprocessed precursor]

CRC64: 5949664A63BF5B41 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MTFSIMRFNP ETDKKPYMQD FELDVSAIQG KMLLNALEAL REKHPDIGLR RSCAEGVCGS 

        70         80         90        100        110        120 
DGMNINGKNA LACVTQLKDL PDRVVVRPLP GFPIIRDLIV DMEQFYAQYK KVKPYLLNDQ 

       130        140        150        160        170        180 
EAPQKERLQS PEERAKLDGL YECILCACCS SSCPSYWWNP DKFIGPAGLL WSYRFIADSR 

       190        200        210        220        230 
DSKEKERLDA MKDPYSVFRC RTIMDCATVC PKNLNPAKAI RKIRTEMLQE TESGE

P51053 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools