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UniProtKB/Swiss-Prot entry P49913


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name CAMP_HUMAN
Primary accession number P49913
Secondary accession number Q71SN9
Integrated into Swiss-Prot on October 1, 1996
Sequence was last modified on October 1, 1996 (Sequence version 1)
Annotations were last modified on    June 16, 2009 (Entry version 79)
Name and origin of the protein
Protein name Cathelicidin antimicrobial peptide [Precursor]
Synonyms 18 kDa cationic antimicrobial protein
CAP-18
hCAP-18
Contains Antibacterial protein FALL-39
     (FALL-39 peptide antibiotic)
Antibacterial protein LL-37
Gene name
Name: CAMP
Synonyms: CAP18, FALL39
ORFNames: HSD26
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND SYNTHESIS OF 132-170.
TISSUE=Bone marrow;
DOI=10.1073/pnas.92.1.195; PubMed=7529412 [NCBI, ExPASy, EBI, Israel, Japan]
Agerberth B., Gunne H., Odeberg J., Kogner P., Boman H.G., Gudmundsson G.H.;
"FALL-39, a putative human peptide antibiotic, is cysteine-free and expressed in bone marrow and testis.";
Proc. Natl. Acad. Sci. U.S.A. 92:195-199(1995).
[2]
NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 42-68 AND 83-100.
TISSUE=Bone marrow;
DOI=10.1016/0014-5793(95)00634-L; PubMed=7615076 [NCBI, ExPASy, EBI, Israel, Japan]
Cowland J.B., Johnsen A.H., Borregaard N.;
"hCAP-18, a cathelin/pro-bactenecin-like protein of human neutrophil specific granules.";
FEBS Lett. 368:173-176(1995).
[3]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Bone marrow;
PubMed=7890387 [NCBI, ExPASy, EBI, Israel, Japan]
Larrick J.W., Hirata M., Balint R.F., Lee J., Zhong J., Wright S.C.;
"Human CAP18: a novel antimicrobial lipopolysaccharide-binding protein.";
Infect. Immun. 63:1291-1297(1995).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1016/S0014-5793(96)01199-4; PubMed=8946956 [NCBI, ExPASy, EBI, Israel, Japan]
Larrick J.W., Lee J., Ma S., Li X., Francke U., Wright S.C., Balint R.F.;
"Structural, functional analysis and localization of the human CAP18 gene.";
FEBS Lett. 398:74-80(1996).
[5]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1111/j.1432-1033.1996.0325z.x; PubMed=8681941 [NCBI, ExPASy, EBI, Israel, Japan]
Gudmundsson G.H., Agerberth B., Odeberg J., Bergman T., Olsson B., Salcedo R.;
"The human gene FALL39 and processing of the cathelin precursor to the antibacterial peptide LL-37 in granulocytes.";
Eur. J. Biochem. 238:325-332(1996).
[6]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Epididymis;
Gao Y., Huang Y.F., Xia X.Y.;
Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases.
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Testis;
Wu N., Miao S.Y., Zhang X.D., Qiao Y., Liang G., Wang L.F.;
"A new spermatogenesis-related gene.";
Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
[8]
NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1128/CDLI.8.2.370-375.2001; PubMed=11238224 [NCBI, ExPASy, EBI, Israel, Japan]
Bals R., Lang C., Weiner D.J., Vogelmeier C., Welsch U., Wilson J.M.;
"Rhesus monkey (Macaca mulatta) mucosal antimicrobial peptides are close homologues of human molecules.";
Clin. Diagn. Lab. Immunol. 8:370-375(2001).
[9]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.;
"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201).";
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
[10]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
Z38026; CAA86115.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X89658; CAA61805.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U19970; AAA74084.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U48795; AAC02634.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X96735; -; NOT_ANNOTATED_CDS; Genomic_DNA.[EMBL / GenBank / DDBJ]
AY162210; AAN78318.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY251531; AAP20054.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF288284; AAG40802.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
CR457083; CAG33364.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
CR541961; CAG46759.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC055089; AAH55089.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00292532; -.
PIR I38932; I38932.
S74248; S74248.
RefSeq NP_004336.2; -.
UniGene Hs.51120
3D structure databases
PDB
2K6O; NMR; -; A=134-170.[ExPASy / RCSB / EBI]
PDBsum 2K6O; -.
DisProt DP00004; -.
ModBase P49913.
Organism-specific databases
GeneCards GC03P048240; -.
H-InvDB HIX0024318; -.
HGNC HGNC:1472; CAMP.
GenAtlas CAMP.
HPA CAB015949; -.
CAB016522; -.
MIM 600474; gene. [NCBI / EBI]
PharmGKB PA26054; -.
Gene expression databases
ArrayExpress P49913; -.
Bgee P49913; -.
CleanEx HS_CAMP; -.
GermOnline ENSG00000164047; Homo sapiens.
Ontologies
GO
GO:0005576; Cellular component: extracellular region (inferred from electronic annotation from UniProtKB-SubCell).
QuickGo view.
Family and domain databases
InterPro IPR001894; Cathelicidin.
IPR018216; Cathelicidin_CS.
Graphical view of domain structure.
PANTHER PTHR10206; Cathelicidin; 1.
Pfam PF00666; Cathelicidins; 1.
Pfam graphical view of domain structure.
ProDom PD001838; Cathelicidin; 1.
[Domain structure / List of seq. sharing at least 1 domain]
PROSITE PS00946; CATHELICIDINS_1; 1.
PS00947; CATHELICIDINS_2; 1.
Proteomic databases
PRIDE P49913; -.
Genome annotation databases
Ensembl ENSG00000164047; Homo sapiens. [Contig view]
GeneID 820; -.
KEGG hsa:820; -.
Phylogenomic databases
HOVERGEN P49913; -.
OMA P49913; QRSSDAN.
Other
NextBio 3356; -.
PMAP-CutDB P49913; -.
SOURCE CAMP; Homo sapiens.
ProtoNet P49913.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Antibiotic; Antimicrobial; Cleavage on pair of basic residues; Direct protein sequencing; Disulfide bond; Pyrrolidone carboxylic acid; Secreted; Signal.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    30  30     Potential. 
PROPEP   31   131  101      PRO_0000004722
CHAIN   132   170  39     Antibacterial protein FALL-39. PRO_0000004723
CHAIN   134   170  37     Antibacterial protein LL-37. PRO_0000004724
MOD_RES   31    31        Pyrrolidone carboxylic acid (By similarity). 
DISULFID   86    97        By similarity. 
DISULFID   108   125        By similarity. 
CONFLICT   6     6        D -> N (in Ref. 1, 6, 7 and 9; CAG46759). 
Sequence information
Length: 170 AA [This is the length of the unprocessed precursor] Molecular weight: 19301 Da [This is the MW of the unprocessed precursor] CRC64: 055B07DCA95A7D16 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MKTQRDGHSL GRWSLVLLLL GLVMPLAIIA QVLSYKEAVL RAIDGINQRS SDANLYRLLD 

        70         80         90        100        110        120 
LDPRPTMDGD PDTPKPVSFT VKETVCPRTT QQSPEDCDFK KDGLVKRCMG TVTLNQARGS 

       130        140        150        160        170 
FDISCDKDNK RFALLGDFFR KSKEKIGKEF KRIVQRIKDF LRNLVPRTES 

P49913 in FASTA format

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