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UniProtKB/Swiss-Prot entry P49033

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MYC_HYLLA
Primary accession number P49033
Secondary accession numbers None
Integrated into Swiss-Prot on February 1, 1996
Sequence was last modified on February 1, 1996 (Sequence version 1)
Annotations were last modified on    June 16, 2009 (Entry version 54)
Name and origin of the protein
Protein name Myc proto-oncogene protein
Synonyms c-Myc
Transcription factor p64
Gene name
Name: MYC
From
Hylobates lar (Common gibbon) [TaxID: 9580] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae; Hylobates.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1016/0378-1119(92)90520-Y; PubMed=1634119 [NCBI, ExPASy, EBI, Israel, Japan]
Eladari M.E., Mohammad-Ali K., Argaut C., Galibert F.;
"Gibbon and marmoset c-myc nucleotide sequences.";
Gene 116:231-243(1992).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M88115; AAA35465.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR JC1178; JC1178.
3D structure databases
HSSP P01106; 1A93. [HSSP ENTRY / PDB]
SMR P49033; 353-434.
ModBase P49033.
Ontologies
GO
GO:0005634; Cellular component: nucleus (inferred from electronic annotation from UniProtKB-SubCell).
GO:0003700; Molecular function: transcription factor activity (inferred from electronic annotation from InterPro).
GO:0006355; Biological process: regulation of transcription, DNA-dependent (inferred from electronic annotation from UniProtKB-KW).
GO:0006350; Biological process: transcription (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR001092; HLH_basic.
IPR011598; HLH_DNA_bd.
IPR003327; Myc-LZ.
IPR002418; Tscrpt_reg_Myc.
IPR012682; Tscrpt_reg_Myc_N.
Graphical view of domain structure.
Gene3D G3DSA:4.10.280.10; HLH_DNA_bd; 1.
Pfam PF00010; HLH; 1.
PF02344; Myc-LZ; 1.
PF01056; Myc_N; 1.
Pfam graphical view of domain structure.
PRINTS PR00044; LEUZIPPRMYC.
SMART SM00353; HLH; 1.
SMART graphical view of domain structure.
PROSITE PS50888; HLH; 1.
PROSITE graphical view of domain structure (profiles).
Phylogenomic databases
HOVERGEN P49033; -.
Other
ProtoNet P49033.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Acetylation; Activator; DNA-binding; Glycoprotein; Nucleus; Phosphoprotein; Proto-oncogene; Transcription; Transcription regulation.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   439  439     Myc proto-oncogene protein. PRO_0000127294
DOMAIN   368   407  40     Helix-loop-helix motif. 
DOMAIN   413   434  22     Leucine-zipper (Potential). 
DNA_BIND   354   367  14     Basic motif. 
COMPBIAS   33    37  5     Poly-Gln. 
COMPBIAS   88    91  4     Poly-Gly. 
MOD_RES   58    58        Phosphothreonine; alternate (By similarity). 
MOD_RES   62    62        Phosphoserine (By similarity). 
MOD_RES   71    71        Phosphoserine (By similarity). 
MOD_RES   143   143        N6-acetyllysine; by PCAF (By similarity). 
MOD_RES   157   157        N6-acetyllysine; by PCAF (By similarity). 
MOD_RES   275   275        N6-acetyllysine; by PCAF (By similarity). 
MOD_RES   317   317        N6-acetyllysine; by PCAF (By similarity). 
MOD_RES   323   323        N6-acetyllysine; by PCAF (By similarity). 
MOD_RES   371   371        N6-acetyllysine; by PCAF (By similarity). 
CARBOHYD   58    58        O-linked (GlcNAc); alternate (By similarity). 
Sequence information
Length: 439 AA [This is the length of the unprocessed precursor] Molecular weight: 48820 Da [This is the MW of the unprocessed precursor] CRC64: 272EB5D9FA89D64B [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MPLNVSFTNR NYDLDYDSVQ PYFYCDEEEN FYQQQQQSEL QPPAPSEDIW KKFELLPTPP 

        70         80         90        100        110        120 
LSPSRRSGLC SPSYVAVTPF SPRGDNDGGG GSFSTADQLE MVTELLGGDM VNQSFICDPD 

       130        140        150        160        170        180 
DETFIKNIII QDCMWSGFSA AAKLVSEKLA SYQAARKDSS SPNPARGHSV CSTSSLYLQD 

       190        200        210        220        230        240 
LSAAASECID PSVVFPYPLN DSSSPKSCAS PDSSAFSPSS DSLLSSTESS PQASPEPLVL 

       250        260        270        280        290        300 
HEETPPTTSS DSEEEQEDEE EIDVVSVEKR QAPSKRSESG SPSAGGHSKP PHSPLVLKRC 

       310        320        330        340        350        360 
HVSTHQHNYA APPSTRKDYP AAKRVKLDSV RVLRQISNNR KCTSPRSSDT EENDKRRTHN 

       370        380        390        400        410        420 
VLERQRRNEL KRSFFALRDQ IPELENNEKA PKVVILKKAT AYILSVQGEE QKLTSEKDLL 

       430 
RKRREQLKHK LEQLRNSCA
P49033 in FASTA format

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