[1]	NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Cao X., Suedhof T.C.; "Nuclear signaling of APP cytoplasmic tail."; Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases.
[2]	NUCLEOTIDE SEQUENCE [MRNA] OF 121-711 (ISOFORM 2). TISSUE=Brain; DOI=10.1093/nar/19.19.5269; PubMed=1923810 [NCBI, ExPASy, EBI, Israel, Japan] Duilio A., Zambrano N., Mogavero A.R., Ammendola R., Cimino F., Russo T.; "A rat brain mRNA encoding a transcriptional activator homologous to the DNA binding domain of retroviral integrases."; Nucleic Acids Res. 19:5269-5274(1991).
[3]	NUCLEOTIDE SEQUENCE [MRNA] OF 243-530. TISSUE=Brain; DOI=10.1093/nar/22.23.4876; PubMed=7800475 [NCBI, ExPASy, EBI, Israel, Japan] Faraonio R., Minopoli G., Porcellini A., Costanzo F., Cimino F., Russo T.; "The DNA sequence encompassing the transcription start site of a TATA-less promoter contains enough information to drive neuron-specific transcription."; Nucleic Acids Res. 22:4876-4883(1994).

Comments

FUNCTION: May modulate the internalization of beta-amyloid precursor protein (By similarity).
SUBUNIT: Binds to the intracellular domain of the beta-amyloid precursor protein. Interacts, through the WW domain, with proline-rich regions of APBB1IP and ENAH (By similarity).
INTERACTION:
P05067:APP (xeno); NbExp=1; IntAct=EBI-286177, EBI-77613;
P08592:App; NbExp=1; IntAct=EBI-286177, EBI-286155;

ALTERNATIVE PRODUCTS: 2 named isoforms [FASTA] produced by alternative splicing.

Name	1
Synonyms	Long
Isoform ID	P46933-1
This is the isoform sequence displayed in this entry.

Name	2
Synonyms	Short
Isoform ID	P46933-2
Features which should be applied to build the isoform sequence: VSP_006798.

TISSUE SPECIFICITY: Brain, not in liver, very low in other tissues. The long (neuron-specific) form is expressed only in brain.
SIMILARITY: Contains 2 PID domains.
SIMILARITY: Contains 1 WW domain.
SEQUENCE CAUTION:
- Sequence=CAA42999.1; Type=Frameshift; Positions=127;

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AF333983; AAK20835.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
X60469; CAA42999.1; ALT_FRAME; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
X60468; CAA42998.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

S22571; S22571.
S50818; S50818.

RefSeq

NP_536726.1; -.

UniGene

Rn.19953

3D structure databases

SMR

P46933; 242-291.

ModBase

P46933.

Protein-protein interaction databases

DIP

DIP:682N; -.

IntAct

P46933; -.

PTM databases

PhosphoSite

P46933; -.

Organism-specific databases

RGD

2122; Apbb1.

Gene expression databases

GermOnline

ENSRNOG00000018020; Rattus norvegicus.

Ontologies

GO:0030426;	Cellular component: growth cone (inferred from sequence or structural similarity from UniProtKB).
GO:0030027;	Cellular component: lamellipodium (inferred from sequence or structural similarity from UniProtKB).
GO:0005634;	Cellular component: nucleus (inferred from sequence or structural similarity from UniProtKB).
GO:0045202;	Cellular component: synapse (inferred from sequence or structural similarity from UniProtKB).
GO:0001540;	Molecular function: beta-amyloid binding (inferred from sequence or structural similarity from UniProtKB).
GO:0008134;	Molecular function: transcription factor binding (inferred from sequence or structural similarity from UniProtKB).
GO:0007050;	Biological process: cell cycle arrest (inferred from sequence or structural similarity from UniProtKB).
GO:0030308;	Biological process: negative regulation of cell growth (inferred from sequence or structural similarity from UniProtKB).
GO:0045749;	Biological process: negative regulation of S phase of mitotic cell cycle (inferred from sequence or structural similarity from UniProtKB).
GO:0050760;	Biological process: negative regulation of thymidylate synthase biosynthetic process (inferred from sequence or structural similarity from UniProtKB).
GO:0045449;	Biological process: regulation of transcription (inferred from sequence or structural similarity from UniProtKB).
QuickGo view.

Family and domain databases

InterPro

IPR011993; PH_type.
IPR006020; PTB_PID.
IPR001202; WW_Rsp5_WWP.
Graphical view of domain structure.

Gene3D

G3DSA:2.30.29.30; PH_type; 2.

Pfam

PF00640; PID; 2.
PF00397; WW; 1.
Pfam graphical view of domain structure.

SMART

SM00462; PTB; 2.
SM00456; WW; 1.
SMART graphical view of domain structure.

PROSITE

PS01179; PID; 2.
PS01159; WW_DOMAIN_1; 1.
PS50020; WW_DOMAIN_2; 1.
PROSITE graphical view of domain structure (profiles).

BLOCKS

P46933.

Genome annotation databases

Ensembl

ENSRNOG00000018020; Rattus norvegicus. [Contig view]

GeneID

29722; -.

KEGG

rno:29722; -.

Phylogenomic databases

HOVERGEN

P46933; -.

Other

ProtoNet

P46933.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Alternative splicing; Repeat.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 711`	`711`	`Amyloid beta A4 precursor protein-binding family B member 1.`	`PRO_0000076051`
`DOMAIN`	`254 286`	`33`	`WW.`
`DOMAIN`	`365 533`	`169`	`PID 1.`
`DOMAIN`	`538 700`	`163`	`PID 2.`
`COMPBIAS`	`148 188`	`41`	`Glu-rich.`
`VAR_SEQ`	`463 464`		`Missing (in isoform 2).`	`VSP_006798`
`CONFLICT`	`137 137`		`L -> K (in Ref. 2).`
`CONFLICT`	`150 154`		`EEKAA -> GRRQR (in Ref. 2).`
`CONFLICT`	`172 172`		`E -> EEEDEEEE (in Ref. 2).`

Sequence information

Length: 711 AA [This is the length of the unprocessed precursor]

Molecular weight: 77656 Da [This is the MW of the unprocessed precursor]

CRC64: A6C9820F5D2BD7BE [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSVPSSLSQS AINANSHGGP ALSFPFPLHA AHNQLLNAKL QATAVVPKDL RSAMGEGSVP 

        70         80         90        100        110        120 
EPGPANAKWL KEGQNQLRRA ATAHRDQNRN VTLTLAEEAS QEAETAPLGP KGLMHLYSEL 

       130        140        150        160        170        180 
ELSAHNAANR GLHGSALIIN TQGLGPDEGE EKAAGEVEEE DEDEEEEDEE EEDLSSPQGL 

       190        200        210        220        230        240 
PEPLENVEVP SGPQVLTDGP REHSKSASLL FGMRNSAASD EDSSWATLSQ GSPSYGSPED 

       250        260        270        280        290        300 
TDSFWNPNAF ETDSDLPAGW MRVQDTSGTY YWHIPTGTTQ WEPPGRASPS QGNSPQEESQ 

       310        320        330        340        350        360 
LTWTGFAHQE GFEEGEFWKD EPSEEAPMEL GLKDPEEGTL PFSAQSLSPE PVPQEEENLP 

       370        380        390        400        410        420 
QRNANPGIKC FAVRSLGWVE MTEEELAPGR SSVAVNNCIR QLSYHKNNLH DPMSGGWGEG 

       430        440        450        460        470        480 
KDLLLQLEDE TLKLVEPQNQ TLLHAQPIVS IRVWGVGRDS GRERDFAYVA RDKLTQMLKC 

       490        500        510        520        530        540 
HVFRCEAPAK NIATSLHEIC SKIMSERRNA RCLVNGLSLD HSKLVDVPFQ VEFPAPKNEL 

       550        560        570        580        590        600 
VQKFQVYYLG NVPVAKPVGV DVINGALESV LSSSSREQWT PSHVSVAPAT LTILHQQTEA 

       610        620        630        640        650        660 
VLGECRVRFL SFLAVGRDVH TFAFIMAAGP ASFCCHMFWC EPNAASLSEA VQAACMLRYQ 

       670        680        690        700        710 
KCLDARSQTS TSCLPAPPAE SVARRVGWTV RRGVQSLWGS LKPKRLGSQT P

P46933 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools