ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!
Search for

UniProtKB/Swiss-Prot entry P44505

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

Note: most headings are clickable, even if they don't appear as links. They link to the user manual or other documents.
Entry information
Entry name AKH_HAEIN
Primary accession number P44505
Secondary accession numbers None
Integrated into Swiss-Prot on November 1, 1995
Sequence was last modified on November 1, 1995 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 60)
Name and origin of the protein
Protein name Bifunctional aspartokinase/homoserine dehydrogenase
Synonym AK-HD
Includes Aspartokinase
     (EC 2.7.2.4)
Homoserine dehydrogenase
     (EC 1.1.1.3)
Gene name
Name: thrA
OrderedLocusNames: HI0089
From
Haemophilus influenzae [TaxID: 727] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales; Pasteurellaceae; Haemophilus.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
PubMed=7542800 [NCBI, ExPASy, EBI, Israel, Japan]
Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd.";
Science 269:496-512(1995).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
L42023; AAC21767.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A64048; A64048.
RefSeq NP_438262.1; -.
3D structure databases
HSSP P31116; 1EBF. [HSSP ENTRY / PDB]
ModBase P44505.
Enzyme and pathway databases
BioCyc HINF71421:HI_0089-MON; -.
Family and domain databases
InterPro IPR002912; ACT_bd.
IPR001048; Asp/Glu/Uridylate_kinase.
IPR005106; Asp/hSer_DHase_NAD-bd.
IPR001341; Asp_kin_reg.
IPR011147; bifunc_aspartokin/hSer_DHase.
IPR001342; hSer_DHase_cat.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.1160.10; Aa_kinase; 1.
G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF00696; AA_kinase; 1.
PF01842; ACT; 2.
PF00742; Homoserine_dh; 1.
PF03447; NAD_binding_3; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000727; ThrA; 1.
TIGRFAMs TIGR00657; asp_kinases; 1.
PROSITE PS00324; ASPARTOKINASE; 1.
PS01042; HOMOSER_DHGENASE; 1.
BLOCKS P44505.
Genome annotation databases
GeneID 950991; -.
GenomeReviews L42023_GR; HI0089.
KEGG hin:HI0089; -.
NMPDR fig|71421.1.peg.88; -.
TIGR HI0089; -.
Phylogenomic databases
HOGENOM P44505; -.
Other
ProtoNet P44505.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Allosteric enzyme; Amino-acid biosynthesis; Complete proteome; Kinase; Multifunctional enzyme; NADP; Oxidoreductase; Repeat; Threonine biosynthesis; Transferase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   815  815     Bifunctional aspartokinase/homoserine dehydrogenase. PRO_0000066687
DOMAIN   316   390  75     ACT 1. 
DOMAIN   397   471  75     ACT 2. 
NP_BIND   471   478  8     NADP (Potential). 
REGION   1   249  249     Aspartokinase. 
REGION   250   470  221     Interface. 
REGION   471   815  345     Homoserine dehydrogenase. 
Sequence information
Length: 815 AA [This is the length of the unprocessed precursor] Molecular weight: 88221 Da [This is the MW of the unprocessed precursor] CRC64: 7FD5512FCC4BE7F7 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MRVLKFGGTS LANPERFSQA AKLIEQAHLE EQAAGVLSAP AKITNHLVAL SEKAALNQST 

        70         80         90        100        110        120 
DTHFNEAIEI FYNIINGLHT ENNQFDLNGT KALIDAEFVQ IKGLLEEIRQ AGKVEDAVKA 

       130        140        150        160        170        180 
TIDCRGEKLS IAMMKAWFEA RGYSVHIVDP VKQLLAKGGY LESSVEIEES TKRVDAANIA 

       190        200        210        220        230        240 
KDKVVLMAGF TAGNEKGELV LLGRNGSDYS AACLAACLGA SVCEIWTDVD GVYTCDPRLV 

       250        260        270        280        290        300 
PDARLLPTLS YREAMELSYF GAKVIHPRTI GPLLPQNIPC VIKNTGNPSA PGSIIDGNVK 

       310        320        330        340        350        360 
SESLQVKGIT NLDNLAMFNV SGPGMQGMVG MASRVFSAMS GAGISVILIT QSSSEYSISF 

       370        380        390        400        410        420 
CVPVKSAEVA KTVLETEFAN ELNEHQLEPI EVIKDLSIIS VVGDGMKQAK GIAARFFSAL 

       430        440        450        460        470        480 
AQANISIVAI AQGSSERSIS AVVPQNKAIE AVKATHQALF NNKKVVDMFL VGVGGVGGEL 

       490        500        510        520        530        540 
IEQVKRQKEY LAKKNVEIRV CAIANSNRML LDENGLNLED WKNDLENATQ PSDFDVLLSF 

       550        560        570        580        590        600 
IKLHHVVNPV FVDCTSAESV AGLYARALKE GFHVVTPNKK ANTRELVYYN ELRQNAQASQ 

       610        620        630        640        650        660 
HKFLYETNVG AGLPVIENLQ NLLAAGDELE YFEGILSGSL SFIFGKLEEG LSLSEVTALA 

       670        680        690        700        710        720 
REKGFTEPDP RDDLSGQDVA RKLLILAREA GIELELSDVE VEGVLPKGFS DGKSADEFMA 

       730        740        750        760        770        780 
MLPQLDEEFK TRVATAKAEG KVLRYVGKIS EGKCKVSIVA VDLNNPLYKV KDGENALAFY 

       790        800        810 
TRYYQPIPLL LRGYGAGNAV TAAGIFADIL RTLQH
P44505 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA) 		Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Hosted by ca flag CBR Canada Mirror sites: Australia Brazil China Korea Switzerland
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!