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UniProtKB/Swiss-Prot entry P43334

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PH4H_PSEAE
Primary accession number P43334
Secondary accession numbers None
Integrated into Swiss-Prot on November 1, 1995
Sequence was last modified on December 8, 2000 (Sequence version 2)
Annotations were last modified on    November 25, 2008 (Entry version 66)
Name and origin of the protein
Protein name Phenylalanine-4-hydroxylase
Synonyms PAH
EC 1.14.16.1
Phe-4-monooxygenase
Gene name
Name: phhA
OrderedLocusNames: PA0872
From
Pseudomonas aeruginosa [TaxID: 287] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228;
PubMed=8108417 [NCBI, ExPASy, EBI, Israel, Japan]
Zhao G., Xia T., Song J., Roy R.A.;
"Pseudomonas aeruginosa possesses homologues of mammalian phenylalanine hydroxylase and 4 alpha-carbinolamine dehydratase/DCoH as part of a three-component gene cluster.";
Proc. Natl. Acad. Sci. U.S.A. 91:1366-1370(1994).
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228;
DOI=10.1038/35023079; PubMed=10984043 [NCBI, ExPASy, EBI, Israel, Japan]
Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P., Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M., Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y., Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M., Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J., Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
"Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.";
Nature 406:959-964(2000).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M88627; AAA25936.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AE004091; AAG04261.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A53452; A53452.
F83535; F83535.
RefSeq NP_249563.1; -.
3D structure databases
HSSP P30967; 1LTZ. [HSSP ENTRY / PDB]
ModBase P43334.
Enzyme and pathway databases
BioCyc PAER208964:PA0872-MON; -.
Organism-specific databases
PseudoCAP PA0872; -.
Ontologies
GO
GO:0005506; Molecular function: iron ion binding (inferred from electronic annotation from InterPro).
GO:0004505; Molecular function: phenylalanine 4-monooxygenase activity (inferred from electronic annotation from InterPro).
GO:0006559; Biological process: L-phenylalanine catabolic process (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR001273; Aaa_hydroxylase.
IPR005960; Phe-4-hydroxylase_mono.
Graphical view of domain structure.
Gene3D G3DSA:1.10.800.10; Aaa_hydroxylase; 1.
PANTHER PTHR11473; Aaa_hydroxylase; 1.
Pfam PF00351; Biopterin_H; 1.
Pfam graphical view of domain structure.
PRINTS PR00372; FYWHYDRXLASE.
ProDom PD002559; Aaa_hydroxylase; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR01267; Phe4hydrox_mono; 1.
PROSITE PS00367; BIOPTERIN_HYDROXYL; 1.
ProtoNet P43334.
Genome annotation databases
GeneID 879709; -.
GenomeReviews AE004091_GR; PA0872.
KEGG pae:PA0872; -.
Phylogenomic databases
HOGENOM P43334; -.
Genome annotation databases
CMR P43334; PA0872.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Iron; Metal-binding; Monooxygenase; Oxidoreductase; Phenylalanine catabolism.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   262  262     Phenylalanine-4-hydroxylase. PRO_0000205555
METAL   121   121        Iron (By similarity). 
METAL   126   126        Iron (By similarity). 
METAL   166   166        Iron (Potential). 
CONFLICT   135   135        F -> L (in Ref. 1; AAA25936). 
Sequence information
Length: 262 AA [This is the length of the unprocessed precursor] Molecular weight: 30322 Da [This is the MW of the unprocessed precursor] CRC64: A5665839C5961A45 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MKTTQYVARQ PDDNGFIHYP ETEHQVWNTL ITRQLKVIEG RACQEYLDGI EQLGLPHERI 

        70         80         90        100        110        120 
PQLDEINRVL QATTGWRVAR VPALIPFQTF FELLASQQFP VATFIRTPEE LDYLQEPDIF 

       130        140        150        160        170        180 
HEIFGHCPLL TNPWFAEFTH TYGKLGLKAS KEERVFLARL YWMTIEFGLV ETDQGKRIYG 

       190        200        210        220        230        240 
GGILSSPKET VYSLSDEPLH QAFNPLEAMR TPYRIDILQP LYFVLPDLKR LFQLAQEDIM 

       250        260 
ALVHEAMRLG LHAPLFPPKQ AA
P43334 in FASTA format

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