[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. PubMed=8284673 [NCBI, ExPASy, EBI, Israel, Japan] Banerjee A., Dubnau E., Quemard A., Balasubramanian V., Um K.S., Wilson T., Collins D., de Lisle G., Jacobs W.R. Jr.; "inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis."; Science 263:227-230(1994).
[2]	NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.; Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: Involved in the resistance against the antituberculosis drugs isoniazid and ethionamide.
CATALYTIC ACTIVITY: Acyl-[acyl-carrier-protein] + NAD⁺ = trans-2,3-dehydroacyl-[acyl-carrier-protein] + NADH.
PATHWAY: Lipid metabolism; fatty acid biosynthesis .
SUBUNIT: Homotetramer (By similarity).
SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

U02530; AAC43211.1; -; Unassigned_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
CP000480; ABK73247.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_887466.1; -.

3D structure databases

HSSP

P46533; 1BVR. [HSSP ENTRY / PDB]

SMR

P42829; 3-269.

ModBase

P42829.

Ontologies

GO:0005488;	Molecular function: binding (inferred from electronic annotation from InterPro).
GO:0004318;	Molecular function: enoyl-[acyl-carrier-protein] reductase (NADH) activity (inferred from electronic annotation from EC).
GO:0006633;	Biological process: fatty acid biosynthetic process (inferred from electronic annotation from UniProtKB-KW).
GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0046677;	Biological process: response to antibiotic (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR002198; DHase_sc/Rdtase_SDR.
IPR014358; Enoyl-ACP_rdct.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.50.720; NAD(P)-bd; 1.

PANTHER

PTHR19410; ADH_short_C2; 1.
PTHR19410:SF12; Enoyl-ACP_rdct; 1.

ProtoNet

P42829.

Genome annotation databases

GeneID

4537137; -.

GenomeReviews

CP000480_GR; MSMEG_3151.

KEGG

msm:MSMEG_3151; -.

NMPDR

fig|246196.1.peg.3159; -.

TIGR

MSMEG_3151; -.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Antibiotic resistance; Complete proteome; Fatty acid biosynthesis; Lipid synthesis; NAD; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 269`	`269`	`Enoyl-[acyl-carrier-protein] reductase [NADH].`	`PRO_0000054913`
`NP_BIND`	`136 165`	`30`	`NAD (Potential).`
`BINDING`	`158 158`		`Substrate (By similarity).`
`VARIANT`	`94 94`	`1`	`S -> A (in strain: mc(2)651; INH-resistant).`

Sequence information

Length: 269 AA [This is the length of the unprocessed precursor]

Molecular weight: 28527 Da [This is the MW of the unprocessed precursor]

CRC64: AD3BD962D2B78FC6 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MTGLLEGKRI LVTGIITDSS IAFHIAKVAQ EAGAELVLTG FDRLKLVKRI ADRLPKPAPL 

        70         80         90        100        110        120 
LELDVQNEEH LSTLADRITA EIGEGNKIDG VVHSIGFMPQ SGMGINPFFD APYEDVSKGI 

       130        140        150        160        170        180 
HISAYSYASL AKAVLPIMNP GGGIVGMDFD PTRAMPAYNW MTVAKSALES VNRFVAREAG 

       190        200        210        220        230        240 
KVGVRSNLVA AGPIRTLAMS AIVGGALGDE AGQQMQLLEE GWDQRAPLGW NMKDPTPVAK 

       250        260 
TVCALLSDWL PATTGTVIYA DGGASTQLL

P42829 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools