[1]	NUCLEOTIDE SEQUENCE. DOI=10.1016/0092-8674(92)90152-3; PubMed=1310899 [NCBI, ExPASy, EBI, Israel, Japan] Lin H.Y., Wang X.-F., Ng-Eaton E., Weinberg R.A., Lodish H.F.; "Expression cloning of the TGF-beta type II receptor, a functional transmembrane serine/threonine kinase."; Cell 68:775-785(1992).

Comments

FUNCTION: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for TGF-beta.
CATALYTIC ACTIVITY: ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
COFACTOR: Magnesium or manganese (By similarity).
SUBUNIT: Binds to DAXX. Interacts with TCTEX1D4 (By similarity).
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
PTM: Phosphorylated on a Ser/Thr residue in the cytoplasmic domain.
SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
SIMILARITY: Contains 1 protein kinase domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

3D structure databases
HSSP	P37173; 1KTZ. [HSSP ENTRY / PDB]
SMR	P38551; 38-159.
ModBase	P38551.
Family and domain databases
InterPro	IPR000719; Prot_kinase_core. IPR017441; Protein_kinase_ATP_bd_CS. IPR008271; Ser_thr_pkin_AS. IPR015769; TGF-beta_II_C. IPR015013; TGF_beta_receptor2. IPR001245; Tyr_pkinase. Graphical view of domain structure.
PANTHER	PTHR23255:SF11; TGF-beta_II_C; 1.
Pfam	PF08917; ecTbetaR2; 1. PF07714; Pkinase_Tyr; 1. Pfam graphical view of domain structure.
ProDom	PD000001; Prot_kinase; 1. [Domain structure / List of seq. sharing at least 1 domain]
PROSITE	PS00107; PROTEIN_KINASE_ATP; 1. PS50011; PROTEIN_KINASE_DOM; 1. PS00108; PROTEIN_KINASE_ST; PARTIAL. PROSITE graphical view of domain structure (profiles).
BLOCKS	P38551.
Phylogenomic databases
HOVERGEN	P38551; -.
Other
ProtoNet	P38551.
UniRef	View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

ATP-binding; Glycoprotein; Kinase; Magnesium; Manganese; Membrane; Metal-binding; Nucleotide-binding; Phosphoprotein; Receptor; Serine/threonine-protein kinase; Signal; Transferase; Transmembrane.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 23`	`23`	`Potential.`
`CHAIN`	`24 >297`	`>274`	`TGF-beta receptor type-2.`	`PRO_0000024428`
`TOPO_DOM`	`24 166`	`143`	`Extracellular (Potential).`
`TRANSMEM`	`167 187`	`21`	`Potential.`
`TOPO_DOM`	`188 >297`	`>110`	`Cytoplasmic (Potential).`
`DOMAIN`	`244 >297`	`>54`	`Protein kinase.`
`NP_BIND`	`250 258`	`9`	`ATP (By similarity).`
`BINDING`	`277 277`		`ATP (By similarity).`
`CARBOHYD`	`70 70`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`94 94`		`N-linked (GlcNAc...) (Potential).`
`DISULFID`	`51 84`		`By similarity.`
`DISULFID`	`54 71`		`By similarity.`
`DISULFID`	`61 67`		`By similarity.`
`DISULFID`	`77 101`		`By similarity.`
`DISULFID`	`121 136`		`By similarity.`
`DISULFID`	`138 143`		`By similarity.`
`NON_TER`	`297 297`

Sequence information

Length: 297 AA [This is the length of the partial sequence of the unprocessed precursor]

Molecular weight: 33302 Da [This is the MW of the partial sequence of the unprocessed precursor]

CRC64: F9869D3079B66A15 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MGRGLLGGLW PLHVVLWTRI ASTIPPHVPK SVNSDMMVTD SNGAVKLPQL CKFCDVRSST 

        70         80         90        100        110        120 
CDNQKSCLSN CSITAICEKP QEVCVAVWRK NDENITIETV CDDPKIAYHG FVLDDAASSK 

       130        140        150        160        170        180 
CIMKERKGSG ETFFMCSCSS DECNDHIIFS EEYATNNPDL LLVIFQVTGV SLLPPLGIAI 

       190        200        210        220        230        240 
AVIITFYCYR VHRQQKLSPS WDSGKPRKLM EFSEHLAIIL EDDRSDISST CANNINHNTE 

       250        260        270        280        290 
LLPIELDTLV GKGRFAEVYK AKLRQNTSEQ FETVAVKIFP YEEYASWKTE KDIFSDL

P38551 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools