[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. DOI=10.1006/jmcc.1994.1103; PubMed=7966354 [NCBI, ExPASy, EBI, Israel, Japan] Kanter H.L., Saffitz J.E., Beyer E.C.; "Molecular cloning of two human cardiac gap junction proteins, connexin40 and connexin45."; J. Mol. Cell. Cardiol. 26:861-868(1994).
[2]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan] The MGC Project Team; "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."; Genome Res. 14:2121-2127(2004).

Comments

FUNCTION: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
SUBUNIT: A connexon is composed of a hexamer of connexins.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
SIMILARITY: Belongs to the connexin family. Gamma-type subfamily.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

U03493; AAA60458.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC096213; AAH96213.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC096214; AAH96214.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC096215; AAH96215.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC096216; AAH96216.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

I38430; I38430.

RefSeq

NP_001073852.1; -.
NP_005488.2; -.

UniGene

Hs.660494

3D structure databases

ModBase

P36383.

PTM databases

PhosphoSite

P36383; -.

Enzyme and pathway databases

Reactome

REACT_9480; Gap junction trafficking and regulation.
REACT_9492; Synthesis of Cx45.

Organism-specific databases

HGNC:4280; GJC1.

608655; gene. [NCBI / EBI]

PharmGKB

PA28691; -.

GeneCards

P36383.

Gene expression databases

ArrayExpress

P36383; -.

CleanEx

HS_GJC1; -.

GermOnline

ENSG00000182963; Homo sapiens.

Ontologies

GO:0005921;	Cellular component: gap junction (traceable author statement from ProtInc).
GO:0007043;	Biological process: cell-cell junction assembly (traceable author statement from ProtInc).
GO:0006936;	Biological process: muscle contraction (traceable author statement from ProtInc).
GO:0006810;	Biological process: transport (non-traceable author statement from ProtInc).
QuickGo view.

Family and domain databases

InterPro

IPR000500; Connexin.
IPR002265; Connexin45.
IPR013092; Connexin_N.
Graphical view of domain structure.

PANTHER

PTHR11984; Connexin; 1.

Pfam

PF00029; Connexin; 1.
Pfam graphical view of domain structure.

PRINTS

PR00206; CONNEXIN.
PR01136; CONNEXINA6.

SMART

SM00037; CNX; 1.
SMART graphical view of domain structure.

PROSITE

PS00407; CONNEXINS_1; 1.
PS00408; CONNEXINS_2; 1.

BLOCKS

P36383.

Genome annotation databases

Ensembl

ENSG00000182963; Homo sapiens. [Contig view]

GeneID

10052; -.

KEGG

hsa:10052; -.

Phylogenomic databases

HOGENOM

P36383; -.

HOVERGEN

P36383; -.

Other

GJC1; Homo sapiens.

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cell junction; Cell membrane; Gap junction; Membrane; Transmembrane.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 396`	`396`	`Gap junction gamma-1 protein.`	`PRO_0000057826`
`TOPO_DOM`	`1 22`	`22`	`Cytoplasmic (Potential).`
`TRANSMEM`	`23 45`	`23`	`Potential.`
`TOPO_DOM`	`46 75`	`30`	`Extracellular (Potential).`
`TRANSMEM`	`76 95`	`20`	`Potential.`
`TOPO_DOM`	`96 175`	`80`	`Cytoplasmic (Potential).`
`TRANSMEM`	`176 198`	`23`	`Potential.`
`TOPO_DOM`	`199 228`	`30`	`Extracellular (Potential).`
`TRANSMEM`	`229 248`	`20`	`Potential.`
`TOPO_DOM`	`249 396`	`148`	`Cytoplasmic (Potential).`

Sequence information

Length: 396 AA [This is the length of the unprocessed precursor]

Molecular weight: 45483 Da [This is the MW of the unprocessed precursor]

CRC64: C9F67C1D878D40DF [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSWSFLTRLL EEIHNHSTFV GKIWLTVLIV FRIVLTAVGG ESIYYDEQSK FVCNTEQPGC 

        70         80         90        100        110        120 
ENVCYDAFAP LSHVRFWVFQ IILVATPSVM YLGYAIHKIA KMEHGEADKK AARSKPYAMR 

       130        140        150        160        170        180 
WKQHRALEET EEDNEEDPMM YPEMELESDK ENKEQSQPKP KHDGRRRIRE DGLMKIYVLQ 

       190        200        210        220        230        240 
LLARTVFEVG FLIGQYFLYG FQVHPFYVCS RLPCPHKIDC FISRPTEKTI FLLIMYGVTG 

       250        260        270        280        290        300 
LCLLLNIWEM LHLGFGTIRD SLNSKRRELE DPGAYNYPFT WNTPSAPPGY NIAVKPDQIQ 

       310        320        330        340        350        360 
YTELSNAKIA YKQNKANTAQ EQQYGSHEEN LPADLEALQR EIRMAQERLD LAVQAYSHQN 

       370        380        390 
NPHGPREKKA KVGSKAGSNK STASSKSGDG KNSVWI

P36383 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools