ID   NEU1_MOUSE              Reviewed;         125 AA.
AC   P35454;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   02-SEP-2008, entry version 62.
DE   RecName: Full=Oxytocin-neurophysin 1;
DE            Short=OT-NPI;
DE   Contains:
DE     RecName: Full=Oxytocin;
DE     AltName: Full=Ocytocin;
DE   Contains:
DE     RecName: Full=Neurophysin 1;
DE   Flags: Precursor;
GN   Name=Oxt;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=91101513; PubMed=2176709; DOI=10.1016/0169-328X(90)90045-F;
RA   Hara Y., Battey J., Gainer H.;
RT   "Structure of mouse vasopressin and oxytocin genes.";
RL   Brain Res. Mol. Brain Res. 8:319-324(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=ILS, and ISS;
RX   MEDLINE=21363810; PubMed=11471062; DOI=10.1007/s00335-001-1001-x;
RA   Ehringer M.A., Thompson J., Conroy O., Xu Y., Yang F., Canniff J.,
RA   Beeson M., Gordon L., Bennett B., Johnson T.E., Sikela J.M.;
RT   "High-throughput sequence identification of gene coding variants
RT   within alcohol-related QTLs.";
RL   Mamm. Genome 12:657-663(2001).
CC   -!- FUNCTION: Neurophysin 1 specifically binds oxytocin.
CC   -!- FUNCTION: Oxytocin causes contraction of the smooth muscle of the
CC       uterus and of the mammary gland.
CC   -!- SIMILARITY: Belongs to the vasopressin/oxytocin family.
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DR   EMBL; M88355; AAC42024.1; -; Genomic_DNA.
DR   EMBL; AF483508; AAL90782.1; -; mRNA.
DR   EMBL; AF483509; AAL90783.1; -; mRNA.
DR   PIR; A43755; A43755.
DR   RefSeq; NP_035155.1; -.
DR   UniGene; Mm.16745; -.
DR   HSSP; P01175; 1L5C.
DR   SMR; P35454; 32-123.
DR   Ensembl; ENSMUSG00000027301; Mus musculus.
DR   GeneID; 18429; -.
DR   KEGG; mmu:18429; -.
DR   MGI; MGI:97453; Oxt.
DR   HOGENOM; P35454; -.
DR   HOVERGEN; P35454; -.
DR   ArrayExpress; P35454; -.
DR   CleanEx; MM_OXT; -.
DR   GermOnline; ENSMUSG00000027301; Mus musculus.
DR   InterPro; IPR000981; Neurhyp_horm.
DR   InterPro; IPR016321; Nonapeptide_hormone_prcur.
DR   Gene3D; G3DSA:2.60.9.10; Neurhyp_horm; 1.
DR   Pfam; PF00220; Hormone_4; 1.
DR   Pfam; PF00184; Hormone_5; 1.
DR   PIRSF; PIRSF001815; Nonapeptide_hormone_precursor; 1.
DR   PRINTS; PR00831; NEUROPHYSIN.
DR   ProDom; PD001676; Neurhyp_horm; 1.
DR   SMART; SM00003; NH; 1.
DR   PROSITE; PS00264; NEUROHYPOPHYS_HORM; 1.
PE   2: Evidence at transcript level;
KW   Amidation; Cleavage on pair of basic residues; Hormone; Signal.
FT   SIGNAL        1     19       By similarity.
FT   PEPTIDE      20     28       Oxytocin.
FT                                /FTId=PRO_0000020497.
FT   CHAIN        32    125       Neurophysin 1.
FT                                /FTId=PRO_0000020498.
FT   MOD_RES      28     28       Glycine amide (By similarity).
FT   DISULFID     20     25       By similarity.
FT   DISULFID     41     85       By similarity.
FT   DISULFID     44     58       By similarity.
FT   DISULFID     52     75       By similarity.
FT   DISULFID     59     65       By similarity.
FT   DISULFID     92    104       By similarity.
FT   DISULFID     98    116       By similarity.
FT   DISULFID    105    110       By similarity.
SQ   SEQUENCE   125 AA;  12851 MW;  96D3135EBBA2436E CRC64;
     MACPSLACCL LGLLALTSAC YIQNCPLGGK RAVLDLDMRK CLPCGPGGKG RCFGPSICCA
     DELGCFVGTA EALRCQEENY LPSPCQSGQK PCGSGGRCAA TGICCSPDGC RTDPACDPES
     AFSER
//