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UniProtKB/Swiss-Prot entry P34130


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name NTF4_HUMAN
Primary accession number P34130
Secondary accession number Q6FH56
Integrated into Swiss-Prot on February 1, 1994
Sequence was last modified on February 1, 1994 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 77)
Name and origin of the protein
Protein name Neurotrophin-4 [Precursor]
Synonyms NT-4
Neutrophic factor 4
Neurotrophin-5
NT-5
Gene name
Name: NTF4
Synonyms: NTF5
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1016/0896-6273(91)90287-A; PubMed=1742028 [NCBI, ExPASy, EBI, Israel, Japan]
Berkemeier L.R., Winslow J.W., Kaplan D.R., Nikolics K., Goeddel D.V., Rosenthal A.;
"Neurotrophin-5: a novel neurotrophic factor that activates trk and trkB.";
Neuron 7:857-866(1991).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
TISSUE=Prostate;
PubMed=1313578 [NCBI, ExPASy, EBI, Israel, Japan]
Ip N.Y., Ibanez C.F., Nye S.H., McClain J., Jones P.F., Gies D.R., Belluscio L., le Beau M.M., Espinosa R. III, Squinto S.P., Persson H., Yancopoulos G.D.;
"Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificity.";
Proc. Natl. Acad. Sci. U.S.A. 89:3060-3064(1992).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.;
"Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201).";
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Ovary;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
X-RAY CRYSTALLOGRAPHY (2.75 ANGSTROMS).
PubMed=10631974 [NCBI, ExPASy, EBI, Israel, Japan]
Robinson R.C., Radziejewski C., Spraggon G., Greenwald J., Kostura M.R., Burtnick L.D., Stuart D.I., Choe S., Jones E.Y.;
"The structures of the neurotrophin 4 homodimer and the brain-derived neurotrophic factor/neurotrophin 4 heterodimer reveal a common Trk-binding site.";
Protein Sci. 8:2589-2597(1999).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M86528; AAA60154.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BT019368; AAV38175.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BT019369; AAV38176.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
CR541900; CAG46698.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC012421; AAH12421.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A42687; A42687.
RefSeq NP_006170.1; -.
UniGene Hs.266902
3D structure databases
PDB
1B8M; X-ray; 2.75 A; B=81-210.[ExPASy / RCSB / EBI]
1B98; X-ray; 2.75 A; A/M=81-210.[ExPASy / RCSB / EBI]
1HCF; X-ray; 2.70 A; A/B=81-210.[ExPASy / RCSB / EBI]
Detailed list of linked structures.
PDBsum 1B8M; -.
1B98; -.
1HCF; -.
ModBase P34130.
Organism-specific databases
H-InvDB HIX0015315; -.
HGNC HGNC:8024; NTF4.
GenAtlas NTF4.
HPA CAB010167; -.
MIM 162662; gene. [NCBI / EBI]
PharmGKB PA31807; -.
GeneCards P34130.
Gene expression databases
ArrayExpress P34130; -.
CleanEx HS_NTF4; -.
GermOnline ENSG00000167744; Homo sapiens.
Ontologies
GO
GO:0008083; Molecular function: growth factor activity (traceable author statement from ProtInc).
GO:0048167; Biological process: regulation of synaptic plasticity (inferred from sequence or structural similarity from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR002072; NGF.
Graphical view of domain structure.
PANTHER PTHR11589; NGF; 1.
Pfam PF00243; NGF; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF001789; NGF; 1.
PRINTS PR00268; NGF.
ProDom PD002052; NGF; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00140; NGF; 1.
SMART graphical view of domain structure.
PROSITE PS00248; NGF_1; 1.
PS50270; NGF_2; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS P34130.
Genome annotation databases
Ensembl ENSG00000167744; Homo sapiens. [Contig view]
GeneID 4909; -.
KEGG hsa:4909; -.
Phylogenomic databases
HOGENOM P34130; -.
HOVERGEN P34130; -.
Other
LinkHub P34130; -.
SOURCE NTF4; Homo sapiens.
ProtoNet P34130.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Cleavage on pair of basic residues; Glycoprotein; Growth factor; Secreted; Signal.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    24  24     Potential. 
PROPEP   25    80  56      PRO_0000019669
CHAIN   81   210  130     Neurotrophin-4. PRO_0000019670
CARBOHYD   76    76        N-linked (GlcNAc...) (Potential). 
DISULFID   97   170         
DISULFID   141   199         
DISULFID   158   201         
STRAND   95    97  3      
STRAND   99   104  6      
STRAND   109   112  4      
STRAND   117   120  4      
STRAND   136   141  6      
TURN   146   148  3      
STRAND   150   153  4      
TURN   163   165  3      
STRAND   168   182  15      
STRAND   189   203  15      
Sequence information
Length: 210 AA [This is the length of the unprocessed precursor] Molecular weight: 22427 Da [This is the MW of the unprocessed precursor] CRC64: DBC6A30195E139AD [This is a checksum on the sequence]
        10         20         30         40         50         60 
MLPLPSCSLP ILLLFLLPSV PIESQPPPST LPPFLAPEWD LLSPRVVLSR GAPAGPPLLF 

        70         80         90        100        110        120 
LLEAGAFRES AGAPANRSRR GVSETAPASR RGELAVCDAV SGWVTDRRTA VDLRGREVEV 

       130        140        150        160        170        180 
LGEVPAAGGS PLRQYFFETR CKADNAEEGG PGAGGGGCRG VDRRHWVSEC KAKQSYVRAL 

       190        200        210 
TADAQGRVGW RWIRIDTACV CTLLSRTGRA 

P34130 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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BLAST logo BLAST submission on ExPASy/SIB
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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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