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[1]
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NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Synovium;
Staten N.R.;
Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
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[2]
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NUCLEOTIDE SEQUENCE [MRNA] OF 30-151.
DOI=10.1016/0378-1119(93)90437-8; PubMed=8359700 [NCBI, ExPASy, EBI, Israel, Japan]
Delafontaine P.,
Lou H.,
Harrison D.G.,
Bernstein K.E.;
"Sequence of a cDNA encoding dog insulin-like growth factor I.";
Gene 130:305-306(1993).
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[3]
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POLYMORPHISM.
DOI=10.1126/science.1137045; PubMed=17412960 [NCBI, ExPASy, EBI, Israel, Japan]
Sutter N.B.,
Bustamante C.D.,
Chase K.,
Gray M.M.,
Zhao K.,
Zhu L.,
Padhukasahasram B.,
Karlins E.,
Davis S.,
Jones P.G.,
Quignon P.,
Johnson G.S.,
Parker H.G.,
Fretwell N.,
Mosher D.S.,
Lawler D.F.,
Satyaraj E.,
Nordborg M.,
Lark K.G., ![]()
Wayne R.K.,
Ostrander E.A.;
"A single IGF1 allele is a major determinant of small size in dogs.";
Science 316:112-115(2007).
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- FUNCTION: The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity.
- SUBCELLULAR LOCATION: Secreted.
- POLYMORPHISM: The domestic dog exhibits greater diversity in body size than any other terrestrial vertebrate. A major quantitative trait locus (QTL) on chromosome 15 influences size variation within a single breed. In particular, a single-nucleotide polymorphism haplotype in IGF1 (synonymous SNP in exon 3) is common to all small breeds (less than 9 kg) and nearly absent from giant breeds (more than 30 kg), suggesting that the same causal sequence variant is a major contributor to body size in all small dogs.
- SIMILARITY: Belongs to the insulin family.
- WEB RESOURCE: Name=Protein Spotlight; Note=A dog's life - Issue 92 of March 2008; URL="http://www.expasy.org/spotlight/back_issues/sptlt092.shtml";.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 153 AA [This is the length of the unprocessed precursor] |
Molecular weight: 16970 Da [This is the MW of the unprocessed precursor] |
CRC64: 19D16DBF9151C0EF [This is a checksum on the sequence] |
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10 20 30 40 50 60
MGKISSLPTQ LFKCCFCDFL KVKMHTVSSS HLFYLALCLL TFPSPATAGP ETLCGAELVD
70 80 90 100 110 120
ALQFVCGDRG FYFNKPTGYG SSSRRAPQTG IVDECCFRSC DLRRLEMYCA PLKPAKSARS
130 140 150
VRAQRHTDMP KAQKEVHLKN ASRGSAGNKN YRM
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P33712 in FASTA format |
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ExPASy Home page
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