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UniProtKB/Swiss-Prot entry P31431


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name SDC4_HUMAN
Primary accession number P31431
Secondary accession numbers O00773 Q16833 Q53FN9
Integrated into Swiss-Prot on July 1, 1993
Sequence was last modified on July 15, 1998 (Sequence version 2)
Annotations were last modified on    June 16, 2009 (Entry version 98)
Name and origin of the protein
Protein name Syndecan-4 [Precursor]
Synonyms SYND4
Amphiglycan
Ryudocan core protein
Gene name
Name: SDC4
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT LEU-12.
TISSUE=Lung fibroblast;
DOI=10.1083/jcb.118.4.961; PubMed=1500433 [NCBI, ExPASy, EBI, Israel, Japan]
David G., van der Schueren B., Marynen P., Cassiman J.-J., van den Berghe H.;
"Molecular cloning of amphiglycan, a novel integral membrane heparan sulfate proteoglycan expressed by epithelial and fibroblastic cells.";
J. Cell Biol. 118:961-969(1992).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1006/bbrc.1993.1122; PubMed=7916598 [NCBI, ExPASy, EBI, Israel, Japan]
Kojima T., Inazawa J., Takamatsu J., Rosenberg R.D., Saito H.;
"Human ryudocan core protein: molecular cloning and characterization of the cDNA, and chromosomal localization of the gene.";
Biochem. Biophys. Res. Commun. 190:814-822(1993).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
TISSUE=Placenta;
PubMed=8797100 [NCBI, ExPASy, EBI, Israel, Japan]
Takagi A., Kojima T., Tsuzuki S., Katsumi A., Yamazaki T., Sugiura I., Hamaguchi M., Saito H.;
"Structural organization and promoter activity of the human ryudocan gene.";
J. Biochem. 119:979-984(1996).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT LEU-12.
TISSUE=Stomach;
Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.;
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/414865a; PubMed=11780052 [NCBI, ExPASy, EBI, Israel, Japan]
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
"The DNA sequence and comparative analysis of human chromosome 20.";
Nature 414:865-871(2001).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Lung;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[7]
INTERACTION WITH CDCP1.
DOI=10.1038/sj.onc.1208582; PubMed=16007225 [NCBI, ExPASy, EBI, Israel, Japan]
Bhatt A.S., Erdjument-Bromage H., Tempst P., Craik C.S., Moasser M.M.;
"Adhesion signaling by a novel mitotic substrate of src kinases.";
Oncogene 24:5333-5343(2005).
[8]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-197, AND MASS SPECTROMETRY.
DOI=10.1016/j.cell.2007.11.025; PubMed=18083107 [NCBI, ExPASy, EBI, Israel, Japan]
Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J., Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L., Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J., Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X., Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.;
"Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.";
Cell 131:1190-1203(2007).
[9]
STRUCTURE BY NMR OF 171-198.
DOI=10.1021/bi002750r; PubMed=11456484 [NCBI, ExPASy, EBI, Israel, Japan]
Shin J., Lee W., Lee D., Koo B.-K., Han I., Lim Y., Woods A., Couchman J.R., Oh E.-S.;
"Solution structure of the dimeric cytoplasmic domain of syndecan-4.";
Biochemistry 40:8471-8478(2001).
[10]
X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 193-198 IN COMPLEX WITH SDCBP.
DOI=10.1016/S0969-2126(03)00125-4; PubMed=12842047 [NCBI, ExPASy, EBI, Israel, Japan]
Kang B.S., Cooper D.R., Devedjiev Y., Derewenda U., Derewenda Z.S.;
"Molecular roots of degenerate specificity in syntenin's PDZ2 domain: reassessment of the PDZ recognition paradigm.";
Structure 11:845-853(2003).
[11]
X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 182-198 IN COMPLEX WITH SDCBP.
DOI=10.1021/bi052225y; PubMed=16533050 [NCBI, ExPASy, EBI, Israel, Japan]
Grembecka J., Cierpicki T., Devedjiev Y., Derewenda U., Kang B.S., Bushweller J.H., Derewenda Z.S.;
"The binding of the PDZ tandem of syntenin to target proteins.";
Biochemistry 45:3674-3683(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X67016; CAA47406.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
D13292; BAA02550.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
D79206; BAA19613.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK222695; BAD96415.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK223243; BAD96963.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL021578; CAA16520.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC030805; AAH30805.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00011564; -.
PIR JC1457; JC1457.
RefSeq NP_002990.2; -.
UniGene Hs.632267
3D structure databases
PDB
1EJP; NMR; -; A/B=171-198.[ExPASy / RCSB / EBI]
1EJQ; NMR; -; A/B=171-198.[ExPASy / RCSB / EBI]
1OBY; X-ray; 1.85 A; P/Q=193-198.[ExPASy / RCSB / EBI]
1YBO; X-ray; 2.30 A; C/D=182-198.[ExPASy / RCSB / EBI]
Detailed list of linked structures.
PDBsum 1EJP; -.
1EJQ; -.
1OBY; -.
1YBO; -.
ModBase P31431.
PTM databases
PhosphoSite P31431; -.
Enzyme and pathway databases
Pathway_Interaction_DB syndecan_pathway; Proteogylcan syndecan-mediated signaling events.
syndecan_4_pathway; Syndecan-4-mediated signaling events.
Organism-specific databases
GeneCards GC20M043387; -.
H-InvDB HIX0015856; -.
HGNC HGNC:10661; SDC4.
GenAtlas SDC4.
HPA CAB013240; -.
HPA005716; -.
MIM 600017; gene. [NCBI / EBI]
PharmGKB PA35591; -.
Gene expression databases
ArrayExpress P31431; -.
Bgee P31431; -.
CleanEx HS_SDC4; -.
GermOnline ENSG00000124145; Homo sapiens.
Ontologies
GO
GO:0005794; Cellular component: Golgi apparatus (inferred from direct assay from HPA).
GO:0005887; Cellular component: integral to plasma membrane (non-traceable author statement from UniProtKB).
GO:0008092; Molecular function: cytoskeletal protein binding (inferred from electronic annotation from InterPro).
GO:0070053; Molecular function: thrombospondin receptor activity (inferred from mutant phenotype from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR003585; Neurexin-like.
IPR001050; Syndecan.
Graphical view of domain structure.
PANTHER PTHR10915; Syndecan; 1.
Pfam PF01034; Syndecan; 1.
Pfam graphical view of domain structure.
SMART SM00294; 4.1m; 1.
SMART graphical view of domain structure.
PROSITE PS00964; SYNDECAN; 1.
Proteomic databases
PRIDE P31431; -.
Genome annotation databases
Ensembl ENSG00000124145; Homo sapiens. [Contig view]
GeneID 6385; -.
KEGG hsa:6385; -.
Phylogenomic databases
HOGENOM P31431; -.
HOVERGEN P31431; -.
OMA P31431; NHIPERA.
Other
NextBio 24792; -.
PMAP-CutDB P31431; -.
SOURCE SDC4; Homo sapiens.
ProtoNet P31431.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Glycoprotein; Heparan sulfate; Membrane; Phosphoprotein; Polymorphism; Proteoglycan; Signal; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    18  18     Potential. 
CHAIN   19   198  180     Syndecan-4. PRO_0000033511
TOPO_DOM   19   145  127     Extracellular (Potential). 
TRANSMEM   146   170  25     Potential. 
TOPO_DOM   171   198  28     Cytoplasmic (Potential). 
MOD_RES   197   197        Phosphotyrosine. 
CARBOHYD   39    39        O-linked (Xyl...) (heparan sulfate) (By similarity). 
CARBOHYD   61    61        O-linked (Xyl...) (heparan sulfate) (Potential). 
CARBOHYD   63    63        O-linked (Xyl...) (heparan sulfate) (Potential). 
VARIANT   12    12  1     F -> L (in dbSNP:rs4458268 [NCBI]). VAR_021851 
STRAND   196   198  3      
Sequence information
Length: 198 AA [This is the length of the unprocessed precursor] Molecular weight: 21642 Da [This is the MW of the unprocessed precursor] CRC64: 8229AA2733F77A10 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MAPARLFALL LFFVGGVAES IRETEVIDPQ DLLEGRYFSG ALPDDEDVVG PGQESDDFEL 

        70         80         90        100        110        120 
SGSGDLDDLE DSMIGPEVVH PLVPLDNHIP ERAGSGSQVP TEPKKLEENE VIPKRISPVE 

       130        140        150        160        170        180 
ESEDVSNKVS MSSTVQGSNI FERTEVLAAL IVGGIVGILF AVFLILLLMY RMKKKDEGSY 

       190 
DLGKKPIYKK APTNEFYA 

P31431 in FASTA format

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