[1]	NUCLEOTIDE SEQUENCE [MRNA]. TISSUE=Cornea; PubMed=1842923 [NCBI, ExPASy, EBI, Israel, Japan] Cooper D.L., Baptist E.W.; "Degenerate oligonucleotide sequence-directed cross-species PCR cloning of the BCP 54/ALDH 3 cDNA: priming from inverted repeats and formation of tandem primer arrays."; PCR Methods Appl. 1:57-62(1991).
[2]	NUCLEOTIDE SEQUENCE [MRNA] OF 1-140. TISSUE=Cornea; DOI=10.1016/0378-1119(91)90174-A; PubMed=2016061 [NCBI, ExPASy, EBI, Israel, Japan] Cooper D.L., Baptist E.W., Enghild J.J., Isola N.R., Klintworth G.K.; "Bovine corneal protein 54K (BCP54) is a homologue of the tumor-associated (class 3) rat aldehyde dehydrogenase (RATALD)."; Gene 98:201-207(1991).
[3]	PARTIAL PROTEIN SEQUENCE. PubMed=2276277 [NCBI, ExPASy, EBI, Israel, Japan] Cooper D.L., Baptist E.W., Enghild J.J., Lee H., Isola N.R., Klintworth G.K.; "Partial amino acid sequence determination of bovine corneal protein 54 K (BCP 54)."; Curr. Eye Res. 9:781-786(1990).

Comments

FUNCTION: This protein may play a central role in corneal transparency. It represents about 50 percent of the corneal epithelial soluble proteins. In the cornea, this enzyme may help in absorbing the damaging UV-B, as well as detoxicating the UV-induced peroxidic aldehydes.
FUNCTION: This protein preferentially oxidizes aromatic aldehyde substrates.
CATALYTIC ACTIVITY: An aldehyde + NAD(P)⁺ + H₂O = an acid + NAD(P)H.
SUBUNIT: Homodimer (By similarity).
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the aldehyde dehydrogenase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

S51969; AAB24736.2; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
M37384; AAA30468.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

PS0412; PS0412.
T01406; T01406.

UniGene

Bt.13116

3D structure databases

HSSP

P11883; 1AD3. [HSSP ENTRY / PDB]

SMR

P30907; 1-230.

ModBase

P30907.

Ontologies

GO:0005737;	Cellular component: cytoplasm (inferred from electronic annotation from UniProtKB-KW).
GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR016163; Ald_DHase_C.
IPR016160; Ald_DHase_CS.
IPR012394; Ald_DHase_NAD(P).
IPR015590; Aldehyde_DHase.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.309.10; Aldehyde_dehydrogenase_C; 1.

PANTHER

PTHR11699; Aldehyde_dehyd; 1.
PTHR11699:SF15; ALDH; 1.

Pfam

PF00171; Aldedh; 2.
Pfam graphical view of domain structure.

PROSITE

PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PS00687; ALDEHYDE_DEHYDR_GLU; PARTIAL.

Genome annotation databases

Ensembl

ENSBTAG00000021113; Bos taurus. [Contig view]

Phylogenomic databases

HOVERGEN

P30907; -.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cytoplasm; Direct protein sequencing; NADP; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`<1 >239`	`>239`	`Aldehyde dehydrogenase, dimeric NADP-preferring.`	`PRO_0000056469`
`ACT_SITE`	`30 30`		`By similarity.`
`NON_TER`	`1 1`
`NON_TER`	`239 239`

Sequence information

Length: 239 AA [This is the length of the partial sequence of the unprocessed precursor]

Molecular weight: 26743 Da [This is the MW of the partial sequence of the unprocessed precursor]

CRC64: 16BD07206287716C [This is a checksum on the sequence]

        10         20         30         40         50         60 
NPHYVDKDRD LDIACRRIAW GKFMNSGQTC VAPDYILCDP SIQSQVVEKL KKSLKEFYGE 

        70         80         90        100        110        120 
DAKKSRDYGR IINSRHFQRV MGLLEGQKVA YGGTGDATTR YIAPTILTDV DPESPVMQEE 

       130        140        150        160        170        180 
VFGPVLPIMC VRSLEEAIQF ITQREKPLAL YVFSPNDKVI KKMIAETSSG GVTANDVVVH 

       190        200        210        220        230 
ISVHSLPYGG VGDSGMGSYH GRKSFETFSH RRSCLVRPLL NEETLKARYP RARPICPDT

P30907 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools