NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Ovary;
DOI=10.1016/0003-9861(91)90354-L; PubMed=1897929 [NCBI, ExPASy, EBI, Israel, Japan]
Terashima M., Toda K., Kawamoto T., Kuribayashi I., Ogawa Y., Maeda T., Shizuta Y.;
"Isolation of a full-length cDNA encoding mouse aromatase P450.";
Arch. Biochem. Biophys. 285:231-237(1991).

Comments

FUNCTION: Catalyzes the formation of aromatic C18 estrogens from C19 androgens.
CATALYTIC ACTIVITY: RH + reduced flavoprotein + O₂ = ROH + oxidized flavoprotein + H₂O.
COFACTOR: Heme group (By similarity).
SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein.
SIMILARITY: Belongs to the cytochrome P450 family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

D00659; BAA00551.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

S13912; S13912.

NP_031836.1; -.

3D structure databases

ModBase

P28649.

PTM databases

PhosphoSite

P28649; -.

Organism-specific databases

MGI

MGI:88587; Cyp19a1.

Gene expression databases

ArrayExpress

P28649; -.

GermOnline

ENSMUSG00000032274; Mus musculus.

Ontologies

GO:0050381;	Molecular function: unspecific monooxygenase activity (inferred from direct assay from MGI).
QuickGo view.

Family and domain databases

InterPro

IPR001128; Cyt_P450.
IPR002401; Cyt_P450_E_grp-I.
Graphical view of domain structure.

Gene3D

G3DSA:1.10.630.10; Cyt_P450; 1.

PANTHER

PTHR19383; Cyt_P450; 1.

Pfam

PF00067; p450; 1.
Pfam graphical view of domain structure.

PRINTS

PR00463; EP450I.
PR00385; P450.

PROSITE

PS00086; CYTOCHROME_P450; 1.

Genome annotation databases

Ensembl

ENSMUSG00000032274; Mus musculus. [Contig view]

GeneID

13075; -.

KEGG

mmu:13075; -.

Phylogenomic databases

HOGENOM

P28649; -.

HOVERGEN

P28649; -.

Other

NextBio

283016; -.

SOURCE

Cyp19a1; Mus musculus.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Heme; Iron; Membrane; Metal-binding; Monooxygenase; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 503`	`503`	`Cytochrome P450 19A1.`	`PRO_0000051957`
`METAL`	`437 437`		`Iron (heme axial ligand) (By similarity).`

Sequence information

Length: 503 AA [This is the length of the unprocessed precursor]

Molecular weight: 58015 Da [This is the MW of the unprocessed precursor]

CRC64: 737400389D1AEFF1 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MFLEMLNPMQ YNVTIMVPET VTVSAMPLLL IMGLLLLIWN CESSSSIPGP GYCLGIGPLI 

        70         80         90        100        110        120 
SHGRFLWMGI GSACNYYNKM YGEFMRVWIS GEETLIISKS SSMFHVMKHS HYISRFGSKR 

       130        140        150        160        170        180 
GLQCIGMHEN GIIFNNNPSL WRTIRPFFMK ALTGPGLVRM VEVCVESIKQ HLDRLGEVTD 

       190        200        210        220        230        240 
TSGYVDVLTL MRHIMLDTSN MLFLGIPLDE SAIVKKIQGY FNAWQALLIK PNIFFKISWL 

       250        260        270        280        290        300 
YRKYERSVKD LKDEIAVLVE KKRHKVSTAE KLEDCMDFAT DLIFAERRGD LTKENVNQCI 

       310        320        330        340        350        360 
LEMLIAAPDT MSVTLYFMLL LVAEYPEVEA AILKEIHTVV GDRDIKIEDI QNLKVVENFI 

       370        380        390        400        410        420 
NESMRYQPVV DLVMRRALED DVIDGYPVKK GTNIILNIGR MHRLEYFPKP NEFTLENFEK 

       430        440        450        460        470        480 
NVPYRYFQPF GFGPRGCAGK YIAMVMMKVV LVTLLRRFQV KTLQKRCIEN IPKKNDLSLH 

       490        500 
PNEDRHLVEI IFSPRNSDKY LQQ

P28649 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools