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UniProtKB/Swiss-Prot entry P28234


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name CXA5_RAT
Primary accession number P28234
Secondary accession numbers None
Integrated into Swiss-Prot on December 1, 1992
Sequence was last modified on January 23, 2007 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 59)
Name and origin of the protein
Protein name Gap junction alpha-5 protein
Synonyms Connexin-40
Cx40
Gene name
Name: Gja5
Synonyms: Cxn-40
From
Rattus norvegicus (Rat) [TaxID: 10116] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE.
STRAIN=Sprague-Dawley;
PubMed=1370487 [NCBI, ExPASy, EBI, Israel, Japan]
Haefliger J.-A., Bruzzone R., Jenkins N.A., Gilbert D.J., Copeland N.G., Paul D.L.;
"Four novel members of the connexin family of gap junction proteins. Molecular cloning, expression, and chromosome mapping.";
J. Biol. Chem. 267:2057-2064(1992).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1007/BF00232759; PubMed=1328644 [NCBI, ExPASy, EBI, Israel, Japan]
Beyer E.C., Reed K.E., Westphale E.M., Kanter H.L., Larson D.M.;
"Molecular cloning and expression of rat connexin40, a gap junction protein expressed in vascular smooth muscle.";
J. Membr. Biol. 127:69-76(1992).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
DOI=10.1006/geno.1997.5025; PubMed=9403066 [NCBI, ExPASy, EBI, Israel, Japan]
Seul K.H., Tadros P.N., Beyer E.C.;
"Mouse connexin40: gene structure and promoter analysis.";
Genomics 46:120-126(1997).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Lung;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M76535; AAA41000.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M83092; AAA41194.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF021806; AAC53502.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF022136; AAC53503.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC070935; AAH70935.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A42053; A42053.
RefSeq NP_062153.1; -.
UniGene Rn.88300
3D structure databases
ModBase P28234.
Organism-specific databases
RGD 2692; Gja5.
Gene expression databases
ArrayExpress P28234; -.
GermOnline ENSRNOG00000017484; Rattus norvegicus.
Family and domain databases
InterPro IPR000500; Connexin.
IPR002264; Connexin40.
IPR013092; Connexin_N.
Graphical view of domain structure.
PANTHER PTHR11984; Connexin; 1.
PTHR11984:SF13; Connexin40; 1.
Pfam PF00029; Connexin; 1.
Pfam graphical view of domain structure.
SMART SM00037; CNX; 1.
SMART graphical view of domain structure.
PROSITE PS00407; CONNEXINS_1; 1.
PS00408; CONNEXINS_2; 1.
BLOCKS P28234.
Genome annotation databases
Ensembl ENSRNOG00000017484; Rattus norvegicus. [Contig view]
GeneID 50563; -.
KEGG rno:50563; -.
Phylogenomic databases
HOVERGEN P28234; -.
Other
ProtoNet P28234.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cell junction; Cell membrane; Gap junction; Membrane; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
INIT_MET   1     1        Removed (By similarity). 
CHAIN   2   356  355     Gap junction alpha-5 protein. PRO_0000057821
TOPO_DOM   2    19  18     Cytoplasmic (Potential). 
TRANSMEM   20    40  21     Potential. 
TOPO_DOM   41    76  36     Extracellular (Potential). 
TRANSMEM   77    97  21     Potential. 
TOPO_DOM   98   163  66     Cytoplasmic (Potential). 
TRANSMEM   164   184  21     Potential. 
TOPO_DOM   185   204  20     Extracellular (Potential). 
TRANSMEM   205   225  21     Potential. 
TOPO_DOM   226   356  131     Cytoplasmic (Potential). 
Sequence information
Length: 356 AA [This is the length of the unprocessed precursor] Molecular weight: 40233 Da [This is the MW of the unprocessed precursor] CRC64: 7D459FE69D9ACF0C [This is a checksum on the sequence]
        10         20         30         40         50         60 
MGDWSFLGEF LEEVHKHSTV IGKVWLTVLF IFRMLVLGTA AESSWGDEQA DFRCDTIQPG 

        70         80         90        100        110        120 
CQNVCYDQAF PISHIRYWVL QIIFVSTPSL VYMGHAMHTV RMQEKQKLRE AEKAKEAGGT 

       130        140        150        160        170        180 
GTYEYLAEKA ELSCWKEVNG KIVLQGTLLN TYVCTILIRT AMEVAFMVGQ YLLYGIFLDT 

       190        200        210        220        230        240 
LHVCRRSPCP HPVNCYVSRP TEKNVFIVFM MAVAGLSLFL SLAELYHLGW KKIRQRLAKS 

       250        260        270        280        290        300 
RQGDKHQLLG PSTSLVQGLT PPPDFNQCLK NSPDEKFFSD FSNNMGSRKN PDPLATEEVP 

       310        320        330        340        350 
NQEQIPEEGF IHTQYGQKPE QPSGASAGHR FPQGYHSDKR RLSKASSKAR SDDLSV 

P28234 in FASTA format

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