ID   ANX13_HUMAN             Reviewed;         316 AA.
AC   P27216; Q9BQR5;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   22-JUL-2008, entry version 81.
DE   RecName: Full=Annexin A13;
DE   AltName: Full=Annexin-13;
DE   AltName: Full=Annexin XIII;
DE   AltName: Full=Annexin, intestine-specific;
DE   AltName: Full=ISA;
GN   Name=ANXA13; Synonyms=ANX13;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), AND MYRISTOYLATION AT GLY-2.
RX   MEDLINE=92112982; PubMed=1530946; DOI=10.1083/jcb.116.2.405;
RA   Wice B.M., Gordon J.I.;
RT   "A strategy for isolation of cDNAs encoding proteins affecting human
RT   intestinal epithelial cell growth and differentiation:
RT   characterization of a novel gut-specific N-myristoylated annexin.";
RL   J. Cell Biol. 116:405-422(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B).
RC   TISSUE=Colon adenocarcinoma;
RX   MEDLINE=21959324; PubMed=11961095;
RA   Iglesias J.M., Morgan R.O., Jenkins N.A., Copeland N.G., Gilbert D.J.,
RA   Fernandez M.-P.;
RT   "Comparative genetics and evolution of annexin A13 as the founder gene
RT   of vertebrate annexins.";
RL   Mol. Biol. Evol. 19:608-618(2002).
CC   -!- SUBCELLULAR LOCATION: Cell membrane. Note=Associated with the
CC       plasma membrane of undifferentiated, proliferating crypt
CC       epithelial cells as well as differentiated villus enterocytes.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=A; Synonyms=Anx13A;
CC         IsoId=P27216-1; Sequence=Displayed;
CC       Name=B; Synonyms=Anx13B;
CC         IsoId=P27216-2; Sequence=VSP_000291;
CC   -!- TISSUE SPECIFICITY: Gut specific.
CC   -!- DOMAIN: A pair of annexin repeats may form one binding site for
CC       calcium and phospholipid.
CC   -!- SIMILARITY: Belongs to the annexin family.
CC   -!- SIMILARITY: Contains 4 annexin repeats.
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DR   EMBL; Z11502; CAA77578.1; -; mRNA.
DR   EMBL; AJ306450; CAC34622.1; -; mRNA.
DR   PIR; A41733; LUHUIS.
DR   RefSeq; NP_001003954.1; -.
DR   RefSeq; NP_004297.2; -.
DR   UniGene; Hs.181107; -.
DR   HSSP; P13214; 1ANN.
DR   Ensembl; ENSG00000104537; Homo sapiens.
DR   GeneID; 312; -.
DR   KEGG; hsa:312; -.
DR   HGNC; HGNC:536; ANXA13.
DR   MIM; 602573; gene.
DR   PharmGKB; PA24826; -.
DR   HOGENOM; P27216; -.
DR   HOVERGEN; P27216; -.
DR   ArrayExpress; P27216; -.
DR   CleanEx; HS_ANXA13; -.
DR   GermOnline; ENSG00000104537; Homo sapiens.
DR   GO; GO:0005886; C:plasma membrane; NAS:UniProtKB.
DR   GO; GO:0005544; F:calcium-dependent phospholipid binding; NAS:UniProtKB.
DR   GO; GO:0030154; P:cell differentiation; NAS:UniProtKB.
DR   InterPro; IPR001464; Annexin.
DR   InterPro; IPR009166; AnnexinXIII.
DR   Gene3D; G3DSA:1.10.220.10; Annexin; 4.
DR   PANTHER; PTHR10502; Annexin; 1.
DR   Pfam; PF00191; Annexin; 4.
DR   PRINTS; PR00196; ANNEXIN.
DR   PRINTS; PR01811; ANNEXINXIII.
DR   ProDom; PD000143; Annexin; 4.
DR   SMART; SM00335; ANX; 4.
DR   PROSITE; PS00223; ANNEXIN; 3.
PE   1: Evidence at protein level;
KW   Alternative splicing; Annexin; Calcium; Calcium/phospholipid-binding;
KW   Cell membrane; Lipoprotein; Membrane; Myristate; Repeat.
FT   INIT_MET      1      1       Removed.
FT   CHAIN         2    316       Annexin A13.
FT                                /FTId=PRO_0000067514.
FT   REPEAT       23     83       Annexin 1.
FT   REPEAT       95    155       Annexin 2.
FT   REPEAT      179    239       Annexin 3.
FT   REPEAT      254    314       Annexin 4.
FT   LIPID         2      2       N-myristoyl glycine.
FT   VAR_SEQ       5      5       H -> HSQSYTLSEGSQQLPKGDSQPSTVVQPLSHPSRNGE
FT                                PEAPQP (in isoform B).
FT                                /FTId=VSP_000291.
FT   CONFLICT    112    112       F -> V (in Ref. 2; CAC34622).
SQ   SEQUENCE   316 AA;  35463 MW;  C2DA06B370A95F87 CRC64;
     MGNRHAKASS PQGFDVDRDA KKLNKACKGM GTNEAAIIEI LSGRTSDERQ QIKQKYKATY
     GKELEEVLKS ELSGNFEKTA LALLDRPSEY AARQLQKAMK GLGTDESVLI EFLCTRTNKE
     IIAIKEAYQR LFDRSLESDV KGDTSGNLKK ILVSLLQANR NEGDDVDKDL AGQDAKDLYD
     AGEGRWGTDE LAFNEVLAKR SYKQLRATFQ AYQILIGKDI EEAIEEETSG DLQKAYLTLV
     RCAQDCEDYF AERLYKSMKG AGTDEETLIR IVVTRAEVDL QGIKAKFQEK YQKSLSDMVR
     SDTSGDFRKL LVALLH
//