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UniProtKB/Swiss-Prot entry P26441


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name CNTF_HUMAN
Primary accession number P26441
Secondary accession numbers None
Integrated into Swiss-Prot on August 1, 1992
Sequence was last modified on August 1, 1992 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 90)
Name and origin of the protein
Protein name Ciliary neurotrophic factor
Synonym CNTF
Gene name
Name: CNTF
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE.
PubMed=1861138 [NCBI, ExPASy, EBI, Israel, Japan]
Masiakowski P., Liu H., Radziejewski C., Lottspeich F., Oberthuer W., Wong V., Lindsay R.M., Furth M.E., Panayotatos N.;
"Recombinant human and rat ciliary neurotrophic factors.";
J. Neurochem. 57:1003-1012(1991).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=1915374 [NCBI, ExPASy, EBI, Israel, Japan]
Negro A., Tolosano E., Skaper S., Martini I., Callegaro L., Silengo L., Fiorini F., Altruda F.;
"Cloning and expression of human ciliary neurotrophic factor.";
Eur. J. Biochem. 201:289-294(1991).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
TISSUE=Lung;
DOI=10.1016/0378-1119(91)90089-T; PubMed=1840538 [NCBI, ExPASy, EBI, Israel, Japan]
Lam A., Fuller F., Miller J., Kloss J., Manthorpe M., Varon M., Cordell B.;
"Sequence and structural organization of the human gene encoding ciliary neurotrophic factor.";
Gene 102:271-276(1991).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1016/0167-4781(91)90038-N; PubMed=1883844 [NCBI, ExPASy, EBI, Israel, Japan]
McDonald J.R., Ko C., Mismer D., Smith D.J., Collins F.;
"Expression and characterization of recombinant human ciliary neurotrophic factor from Escherichia coli.";
Biochim. Biophys. Acta 1090:70-80(1991).
[5]
NUCLEOTIDE SEQUENCE.
TISSUE=Sciatic nerve;
DOI=10.1038/ng0594-79; PubMed=8075647 [NCBI, ExPASy, EBI, Israel, Japan]
Takahashi R., Yokoji H., Misawa H., Hayashi M., Hu J., Deguchi T.;
"A null mutation in the human CNTF gene is not causally related to neurological diseases.";
Nat. Genet. 7:79-84(1994).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[7]
X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 1-187.
PubMed=7796798 [NCBI, ExPASy, EBI, Israel, Japan]
McDonald N.Q., Panayotatos N., Hendrickson W.A.;
"Crystal structure of dimeric human ciliary neurotrophic factor determined by MAD phasing.";
EMBO J. 14:2689-2699(1995).
[8]
VARIANT ARG-182.
DOI=10.1038/10290; PubMed=10391209 [NCBI, ExPASy, EBI, Israel, Japan]
Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N., Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L., Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q., Lander E.S.;
"Characterization of single-nucleotide polymorphisms in coding regions of human genes.";
Nat. Genet. 22:231-238(1999).
[9]
ERRATUM.
Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N., Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L., Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q., Lander E.S.;
Nat. Genet. 23:373-373(1999).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X60542; CAA43032.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X60477; CAA43009.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X60478; CAA43009.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X55889; CAA39374.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X55890; CAA39374.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC068030; AAH68030.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC074963; AAH74963.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC074964; AAH74964.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR JH0455; UNHUCF.
RefSeq NP_000605.1; -.
UniGene Hs.632114
3D structure databases
PDB
1CNT; X-ray; 2.40 A; 1/2/3/4=1-187.[ExPASy / RCSB / EBI]
PDBsum 1CNT; -.
ModBase P26441.
Protein-protein interaction databases
DIP DIP:5776N; -.
IntAct P26441; -.
Organism-specific databases
H-InvDB HIX0009648; -.
HGNC HGNC:2169; CNTF.
GenAtlas CNTF.
MIM 118945; gene. [NCBI / EBI]
PharmGKB PA26683; -.
GeneCards P26441.
Gene expression databases
ArrayExpress P26441; -.
CleanEx HS_CNTF; -.
GermOnline ENSG00000205003; Homo sapiens.
Ontologies
GO
GO:0005127; Molecular function: ciliary neurotrophic factor receptor binding (traceable author statement from ProtInc).
GO:0007165; Biological process: signal transduction (non-traceable author statement from ProtInc).
QuickGo view.
Family and domain databases
InterPro IPR012351; 4_helix_cytokine_core.
IPR000151; Cil_neuro_factor.
Graphical view of domain structure.
Gene3D G3DSA:1.20.1250.10; 4_helix_cytokine_core; 1.
Pfam PF01110; CNTF; 1.
Pfam graphical view of domain structure.
ProDom PD011041; Cil_neuro_factor; 1.
[Domain structure / List of seq. sharing at least 1 domain]
BLOCKS P26441.
Genome annotation databases
Ensembl ENSG00000186660; Homo sapiens. [Contig view]
GeneID 1270; -.
KEGG hsa:1270; -.
Phylogenomic databases
HOGENOM P26441; -.
HOVERGEN P26441; -.
Other
LinkHub P26441; -.
SOURCE CNTF; Homo sapiens.
ProtoNet P26441.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Cytoplasm; Developmental protein; Differentiation; Growth factor; Neurogenesis; Pharmaceutical; Polymorphism.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   200  200     Ciliary neurotrophic factor. PRO_0000149519
VARIANT   49    49  1     N -> S (in dbSNP:rs17152779 [NCBI]). VAR_033777 
VARIANT   182   182  1     H -> R (in dbSNP:rs6266 [NCBI]). VAR_013924 
HELIX   13    41  29      
HELIX   69    95  27      
TURN   96    98  3      
STRAND   99   101  3      
HELIX   104   129  26      
STRAND   138   140  3      
HELIX   152   180  29      
Sequence information
Length: 200 AA [This is the length of the unprocessed precursor] Molecular weight: 22931 Da [This is the MW of the unprocessed precursor] CRC64: EDD9D895BDA6F35A [This is a checksum on the sequence]
        10         20         30         40         50         60 
MAFTEHSPLT PHRRDLCSRS IWLARKIRSD LTALTESYVK HQGLNKNINL DSADGMPVAS 

        70         80         90        100        110        120 
TDQWSELTEA ERLQENLQAY RTFHVLLARL LEDQQVHFTP TEGDFHQAIH TLLLQVAAFA 

       130        140        150        160        170        180 
YQIEELMILL EYKIPRNEAD GMPINVGDGG LFEKKLWGLK VLQELSQWTV RSIHDLRFIS 

       190        200 
SHQTGIPARG SHYIANNKKM 

P26441 in FASTA format

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