[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. PubMed=3184206 [NCBI, ExPASy, EBI, Israel, Japan] Whittemore S.R., Friedman P.L., Larhammar D.G., Persson H., Gonzalez-Carvajal M., Holets V.R.; "Rat beta-nerve growth factor sequence and site of synthesis in the adult hippocampus."; J. Neurosci. Res. 20:403-410(1988).
[2]	NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 178-219. STRAIN=Sprague-Dawley; TISSUE=Liver; DOI=10.1016/0896-6273(91)90180-8; PubMed=2025430 [NCBI, ExPASy, EBI, Israel, Japan] Hallboeoek F., Ibanez C.F., Persson H.; "Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary."; Neuron 6:845-858(1991).

Comments

FUNCTION: Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. It stimulates division and differentiation of sympathetic and embryonic sensory neurons.
SUBUNIT: Homodimer.
SUBCELLULAR LOCATION: Secreted.
SIMILARITY: Belongs to the NGF-beta family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

M36589; AAA41697.1; ALT_INIT; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

I56570; I56570.

UniGene

Rn.22168

3D structure databases

HSSP

P01139; 1BET. [HSSP ENTRY / SWISS-3DIMAGE / PDB]

SMR

P25427; 129-239.

ModBase

P25427.

Organism-specific databases

RGD

1598328; Ngfb.

Gene expression databases

ArrayExpress

P25427; -.

GermOnline

ENSRNOG00000016571; Rattus norvegicus.

Ontologies

GO:0005788;	Cellular component: endoplasmic reticulum lumen (inferred from experiment from Reactome).
GO:0005576;	Cellular component: extracellular region (inferred from experiment from Reactome).
GO:0005796;	Cellular component: Golgi lumen (inferred from experiment from Reactome).
QuickGo view.

Family and domain databases

InterPro

IPR002072; NGF.
Graphical view of domain structure.

PANTHER

PTHR11589; NGF; 1.

Pfam

PF00243; NGF; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF001789; NGF; 1.

PRINTS

PR00268; NGF.

ProDom

PD002052; NGF; 2.
[Domain structure / List of seq. sharing at least 1 domain]

SMART

SM00140; NGF; 1.
SMART graphical view of domain structure.

PROSITE

PS00248; NGF_1; 1.
PS50270; NGF_2; 1.
PROSITE graphical view of domain structure (profiles).

BLOCKS

P25427.

Genome annotation databases

Ensembl

ENSRNOG00000016571; Rattus norvegicus. [Contig view]

NMPDR

fig|10116.3.peg.16731; -.

Phylogenomic databases

HOVERGEN

P25427; -.

Other

ProtoNet

P25427.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cleavage on pair of basic residues; Glycoprotein; Growth factor; Phosphoprotein; Secreted; Signal.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 18`	`18`	`Potential.`
`PROPEP`	`19 121`	`103`	`Potential.`	`PRO_0000019609`
`CHAIN`	`122 241`	`120`	`Beta-nerve growth factor.`	`PRO_0000019610`
`MOD_RES`	`84 84`		`Phosphoserine (By similarity).`
`CARBOHYD`	`69 69`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`114 114`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`166 166`		`N-linked (GlcNAc...) (Potential).`
`DISULFID`	`136 201`		`By similarity.`
`DISULFID`	`179 229`		`By similarity.`
`DISULFID`	`189 231`		`By similarity.`

Sequence information

Length: 241 AA [This is the length of the unprocessed precursor]

Molecular weight: 27010 Da [This is the MW of the unprocessed precursor]

CRC64: 665F42371563213D [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSMLFYTLIT AFLIGVQAEP YTDSNVPEGD SVPEAHWTKL QHSLDTALRR ARSAPAEPIA 

        70         80         90        100        110        120 
ARVTGQTRNI TVDPKLFKKR RLRSPRVLFS TQPPPTSSDT LDLDFQAHGT ISFNRTHRSK 

       130        140        150        160        170        180 
RSSTHPVFHM GEFSVCDSVS VWVGDKTTAT DIKGKEVTVL GEVNINNSVF KQYFFETKCR 

       190        200        210        220        230        240 
APNPVESGCR GIDSKHWNSY CTTTHTFVKA LTTDDKQAAW RFIRIDTACV CVLSRKAARR 


G

P25427 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools