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[1]
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PROTEIN SEQUENCE.
PubMed=6202840 [NCBI, ExPASy, EBI, Israel, Japan]
Deibler G.E.,
Martenson R.E.,
Krutzsch H.C.,
Kies M.W.;
"Sequence of guinea pig myelin basic protein.";
J. Neurochem. 43:100-105(1984).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA] OF 7-156.
STRAIN=Hartley;
TISSUE=Spinal cord;
Kim G.,
Tanuma N.,
Matsumoto Y.;
"DNA vaccination using Guinea pig myelin basic protein coding region in experimental autoimmune encephalomyelitis.";
Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases.
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[3]
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PROTEIN SEQUENCE OF 45-87.
Shapira R.,
McKneally S.S.,
Chou F.,
Kibler R.F.;
"Encephalitogenic fragment of myelin basic protein. Amino acid sequence of bovine, rabbit, guinea pig, monkey, and human fragments.";
J. Biol. Chem. 246:4630-4640(1971).
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[4]
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POST-TRANSLATIONAL MODIFICATIONS.
PubMed=51849 [NCBI, ExPASy, EBI, Israel, Japan]
Deibler G.E.,
Martenson R.E.,
Kramer A.J.,
Kies M.W.;
"The contribution of phosphorylation and loss of COOH-terminal arginine to the microheterogeneity of myelin basic protein.";
J. Biol. Chem. 250:7931-7938(1975).
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- FUNCTION: Is, with PLP, the most abundant protein component of the myelin membrane in the CNS. Has a role in both the formation and stabilization of this compact multilayer arrangement of bilayers. Each splice variant and charge isomer may have a specialized function in the assembly of an optimized, biochemically functional myelin membrane (By similarity).
- SUBUNIT: Homodimer (By similarity).
- SUBCELLULAR LOCATION: Myelin membrane; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic side of myelin.
- TISSUE SPECIFICITY: Found in both the central and the peripheral nervous system.
- PTM: At least 5 charge isomers; C1 (the most cationic, least modified, and most abundant form), C2, C3, C4 and C5 (the least cationic form); are produced as a result of optional post-translational modifications such as phosphorylation of serine or threonine residues, deamidation of glutamine or asparagine residues, citrullination and methylation of arginine residues. C1 and C2 are unphosphorylated, C3 and C4 are monophosphorylated and C5 is phosphorylated at two positions.
- SIMILARITY: Belongs to the myelin basic protein family.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 167 AA [This is the length of the unprocessed precursor] |
Molecular weight: 18213 Da [This is the MW of the unprocessed precursor] |
CRC64: 866D31F1E5ACFEA6 [This is a checksum on the sequence] |
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10 20 30 40 50 60
ASQKRPSQRH GSKYLATAST MDHARHGFLP RHRDTGILDS IGRFFGSDRA APKRGSGKDS
70 80 90 100 110 120
HHAARTTHYG SLPQKSQRSQ DENPVVHFFK NIVTPRTPPP SQGKGRGLSL SRFSWGAEGQ
130 140 150 160
KPGFGYGGRA DYKSKGFKGA HDAQGTLSKI FKLGGRDSRS GSPMARR
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P25188 in FASTA format |
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