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UniProtKB/Swiss-Prot entry P25183

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name RCC1_XENLA
Primary accession number P25183
Secondary accession numbers None
Integrated into Swiss-Prot on May 1, 1992
Sequence was last modified on May 1, 1992 (Sequence version 1)
Annotations were last modified on    June 16, 2009 (Entry version 56)
Name and origin of the protein
Protein name Regulator of chromosome condensation
Synonyms None
Gene name
Name: rcc1
From
Xenopus laevis (African clawed frog) [TaxID: 8355] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Mesobatrachia; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
PubMed=2361953 [NCBI, ExPASy, EBI, Israel, Japan]
Nishitani H., Kobayashi H., Ohtsubo M., Nishimoto T.;
"Cloning of Xenopus RCC1 cDNA, a homolog of the human RCC1 gene: complementation of tsBN2 mutation and identification of the product.";
J. Biochem. 107:228-235(1990).
Comments
  • FUNCTION: Promotes the exchange of Ran-bound GDP by GTP. Involved in the regulation of onset of chromosome condensation in the S phase. Binds to the chromatin. RCC1/Ran complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA (By similarity).
  • SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Becomes dispersed throughout the cytoplasm during mitosis.
  • SIMILARITY: Contains 7 RCC1 repeats.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
D00679; BAA00586.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
D00646; BAA00542.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR I51559; I51559.
RefSeq NP_001081229.1; -.
UniGene Xl.29555
3D structure databases
HSSP P18754; 1I2M. [HSSP ENTRY / PDB]
SMR P25183; 31-423.
ModBase P25183.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from UniProtKB-SubCell).
GO:0005634; Cellular component: nucleus (inferred from electronic annotation from UniProtKB-SubCell).
GO:0005085; Molecular function: guanyl-nucleotide exchange factor activity (inferred from electronic annotation from UniProtKB-KW).
GO:0051301; Biological process: cell division (inferred from electronic annotation from UniProtKB-KW).
GO:0007067; Biological process: mitosis (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR000408; Reg_chr_condens.
IPR009091; Reg_csome_cond/b-lactamase_inh.
Graphical view of domain structure.
Gene3D G3DSA:2.130.10.30; Reg_csome_cond/b-lactamase_inh; 1.
Pfam PF00415; RCC1; 7.
Pfam graphical view of domain structure.
PRINTS PR00633; RCCNDNSATION.
PROSITE PS00625; RCC1_1; 1.
PS00626; RCC1_2; 5.
PS50012; RCC1_3; 7.
PROSITE graphical view of domain structure (profiles).
Genome annotation databases
GeneID 397722; -.
KEGG xla:397722; -.
Phylogenomic databases
HOVERGEN P25183; -.
Other
ProtoNet P25183.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cell cycle; Cell division; Cytoplasm; Guanine-nucleotide releasing factor; Mitosis; Nucleus; Repeat.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   424  424     Regulator of chromosome condensation. PRO_0000206631
REPEAT   40    90  51     RCC1 1. 
REPEAT   91   142  52     RCC1 2. 
REPEAT   144   195  52     RCC1 3. 
REPEAT   197   262  66     RCC1 4. 
REPEAT   263   316  54     RCC1 5. 
REPEAT   317   367  51     RCC1 6. 
REPEAT   368   421  54     RCC1 7. 
VARIANT   27    30  4     Missing (in clone lambda O-23). 
Sequence information
Length: 424 AA [This is the length of the unprocessed precursor] Molecular weight: 45071 Da [This is the MW of the unprocessed precursor] CRC64: DCF77FCCEBAB6639 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MKGKKTLKRT IAAEESNGTS DVKKTKALPI VTHPSHGTVG GQVLTLGQGD VGQLGLGEDI 

        70         80         90        100        110        120 
MERKKPALVT LTEDIVQAAA GGMHTVCLGA SGSIYTFGCN DEGALGRDTS EEGSEMQPGK 

       130        140        150        160        170        180 
VELAEKVVQV SAGDSHTAAL TEDGRVFVFG SFRDNNGVIG LLEPMKKSMV PVQVQINTPV 

       190        200        210        220        230        240 
IKIASGNDHL VLLTVDGDLY TSGCGEQGQL GRVPERFTNR GGRKGLERLL VPQCIHLKAK 

       250        260        270        280        290        300 
GSGRVHFQDV FCGAYFTFAV SQEGHVYGFG LSNYHQLGTK NTQACYAPQN LTSFKNSTKS 

       310        320        330        340        350        360 
WIGFSGGQHH TVCVDSEGKA YSLGRAEYGR LGLGENAEEQ SEPTPIPDLP KINSVASGAS 

       370        380        390        400        410        420 
VSYAVSTDGC VFAWGMGTNL QLGTGEEEDV WSPEQMTGKH LEDREVLSVS SGGQHTVLLV 


RKRS
P25183 in FASTA format

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