NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
STRAIN=Sprague-Dawley;
TISSUE=Aorta;
DOI=10.1073/pnas.87.8.3052; PubMed=2109324 [NCBI, ExPASy, EBI, Israel, Japan]
Ross P.C., Figler R.A., Corjay M.H., Barber C.M., Adam N., Harcus D.R., Lynch K.R.;
"RTA, a candidate G protein-coupled receptor: cloning, sequencing, and tissue distribution.";
Proc. Natl. Acad. Sci. U.S.A. 87:3052-3056(1990).

Comments

FUNCTION: Orphan receptor. May bind to a neuropeptide and may regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity).
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Gut, vas deferens, uterus and aorta; barely detectable in liver, kidney, lung, and salivary gland. In the brain, markedly abundant in the cerebellum.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Mas subfamily [view classification].

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

M35297; AAA42087.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
M35298; AAA42088.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

IPI00362222; -.

A35639; A35639.

NP_714944.1; -.

3D structure databases

ModBase

P23749.

Protein family/group databases

GPCRDB

P23749; MRGRF_RAT.

Organism-specific databases

RGD

708478; Mrgprf.

Gene expression databases

ArrayExpress

P23749; -.

GermOnline

ENSRNOG00000013426; Rattus norvegicus.

Ontologies

GO:0016021;	Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0005886;	Cellular component: plasma membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0004930;	Molecular function: G-protein coupled receptor activity (traceable author statement from RGD).
GO:0007186;	Biological process: G-protein coupled receptor protein signaling pathway (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR000276; 7TM_GPCR_Rhodpsn.
IPR017452; GPCR_Rhodpsn_supfam.
Graphical view of domain structure.

Pfam

PF00001; 7tm_1; 1.
Pfam graphical view of domain structure.

PRINTS

PR00237; GPCRRHODOPSN.

PROSITE

PS00237; G_PROTEIN_RECEP_F1_1; 1.
PS50262; G_PROTEIN_RECEP_F1_2; 1.
PROSITE graphical view of domain structure (profiles).

Genome annotation databases

Ensembl

ENSRNOG00000013426; Rattus norvegicus. [Contig view]

GeneID

266762; -.

KEGG

rno:266762; -.

Phylogenomic databases

HOVERGEN

P23749; -.

Other

624612; -.

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane; Receptor; Transducer; Transmembrane.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 343`	`343`	`Mas-related G-protein coupled receptor member F.`	`PRO_0000069766`
`TOPO_DOM`	`1 44`	`44`	`Extracellular (Potential).`
`TRANSMEM`	`45 66`	`22`	`1 (Potential).`
`TOPO_DOM`	`67 82`	`16`	`Cytoplasmic (Potential).`
`TRANSMEM`	`83 104`	`22`	`2 (Potential).`
`TOPO_DOM`	`105 123`	`19`	`Extracellular (Potential).`
`TRANSMEM`	`124 144`	`21`	`3 (Potential).`
`TOPO_DOM`	`145 160`	`16`	`Cytoplasmic (Potential).`
`TRANSMEM`	`161 181`	`21`	`4 (Potential).`
`TOPO_DOM`	`182 198`	`17`	`Extracellular (Potential).`
`TRANSMEM`	`199 220`	`22`	`5 (Potential).`
`TOPO_DOM`	`221 241`	`21`	`Cytoplasmic (Potential).`
`TRANSMEM`	`242 263`	`22`	`6 (Potential).`
`TOPO_DOM`	`264 273`	`10`	`Extracellular (Potential).`
`TRANSMEM`	`274 294`	`21`	`7 (Potential).`
`TOPO_DOM`	`295 343`	`49`	`Cytoplasmic (Potential).`
`CARBOHYD`	`4 4`		`N-linked (GlcNAc...) (Potential).`

Sequence information

Length: 343 AA [This is the length of the unprocessed precursor]

Molecular weight: 38364 Da [This is the MW of the unprocessed precursor]

CRC64: E4630007770941F4 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MAGNCSWEAH STNQNKMCPG MSEALELYSR GFLTIEQIAT LPPPAVTNYI FLLLCLCGLV 

        70         80         90        100        110        120 
GNGLVLWFFG FSIKRTPFSI YFLHLASADG IYLFSKAVIA LLNMGTFLGS FPDYVRRVSR 

       130        140        150        160        170        180 
IVGLCTFFAG VSLLPAISIE RCVSVIFPMW YWRRRPKRLS AGVCALLWLL SFLVTSIHNY 

       190        200        210        220        230        240 
FCMFLGHEAS GTACLNMDIS LGILLFFLFC PLMVLPCLAL ILHVECRARR RQRSAKLNHV 

       250        260        270        280        290        300 
VLAIVSVFLV SSIYLGIDWF LFWVFQIPAP FPEYVTDLCI CINSSAKPIV YFLAGRDKSQ 

       310        320        330        340 
RLWEPLRVVF QRALRDGAEP GDAASSTPNT VTMEMQCPSG NAS

P23749 in FASTA format

View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools