NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1016/0378-1119(88)90537-9; PubMed=2838396 [NCBI, ExPASy, EBI, Israel, Japan]
Okazaki N., Hibino Y., Asano Y., Ohmori M., Numao N., Kondo K.;
"Cloning and nucleotide sequencing of phenylalanine dehydrogenase gene of Bacillus sphaericus.";
Gene 63:337-341(1988).

Comments

CATALYTIC ACTIVITY: L-phenylalanine + H₂O + NAD⁺ = phenylpyruvate + NH₃ + NADH.
PATHWAY: Amino-acid biosynthesis; L-phenylalanine biosynthesis; L-phenylalanine from phenylpyruvate (PDH route): step 1/1 .
SIMILARITY: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

M26661; AAA22646.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

I39939; I39939.

3D structure databases

HSSP

Q59771; 1C1D. [HSSP ENTRY / PDB]

ModBase

P23307.

Ontologies

GO:0050175;	Molecular function: phenylalanine dehydrogenase activity (inferred from electronic annotation from EC).
GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR006095; Glu/Leu/Phe/Val_DHase.
IPR006096; Glu/Leu/Phe/Val_DHase_C.
IPR006097; Glu/Leu/Phe/Val_DHase_dimer.
IPR016211; Glu/Phe/Leu/Val_DHase_bac/arc.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.50.720; NAD(P)-bd; 1.

Pfam

PF00208; ELFV_dehydrog; 1.
PF02812; ELFV_dehydrog_N; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF000188; Phe_leu_dh; 1.

PRINTS

PR00082; GLFDHDRGNASE.

PROSITE

PS00074; GLFV_DEHYDROGENASE; 1.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

NAD; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 381`	`381`	`Phenylalanine dehydrogenase.`	`PRO_0000182807`
`NP_BIND`	`191 197`	`7`	`NAD (Potential).`
`ACT_SITE`	`91 91`		`By similarity.`

Sequence information

Length: 381 AA [This is the length of the unprocessed precursor]

Molecular weight: 41578 Da [This is the MW of the unprocessed precursor]

CRC64: D32450CE397ACA67 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MAKQLEKSSK IGNEDVFQKI ANHEQIVFCN DPVSGLQAII AIHDTTLGPA LGGTRMYPYK 

        70         80         90        100        110        120 
NVDEALEDVL RLSEGMTYKC AAADIDFGGG KAVIIGDPEK DKSPALFRAF GQFVESLNGR 

       130        140        150        160        170        180 
FYTGTDMGTT MDDFVHAQKE TNFINGIPEQ YGGSGDSSIP TAQGVIYALK ATNQYLFGSD 

       190        200        210        220        230        240 
SLSGKTYAIQ GLGKVGYKVA EQLLKAGADL FVTDIHENVL NSIKQKSEEL GGSVTIVKSD 

       250        260        270        280        290        300 
DIYSVQADIF VPCAMGGIIN DKTIPKLKVK AVVGSANNQL KDLRHANVLN EKGILYAPDY 

       310        320        330        340        350        360 
IVNAGGLIQV ADELYGPNKE RVLLKTKEIY RSLLEIFNQA ALDCITTVEA ANRKCQKTIE 

       370        380 
GQQTRNSFFS RGRRPKWNIK E

P23307 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools