ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!
Search for

UniProtKB/Swiss-Prot entry P22455


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

Note: most headings are clickable, even if they don't appear as links. They link to the user manual or other documents.
Entry information
Entry name FGFR4_HUMAN
Primary accession number P22455
Secondary accession numbers O43785 Q14309
Integrated into Swiss-Prot on August 1, 1991
Sequence was last modified on April 27, 2001 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 100)
Name and origin of the protein
Protein name Fibroblast growth factor receptor 4 [Precursor]
Synonyms FGFR-4
EC 2.7.10.1
CD334 antigen
Gene name
Name: FGFR4
Synonyms: JTK2, TKF
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=1709094 [NCBI, ExPASy, EBI, Israel, Japan]
Partanen J.M., Maekelae T.P., Eerola E., Korhonen J., Hirvonen H., Claesson-Welsh L., Alitalo K.;
"FGFR-4, a novel acidic fibroblast growth factor receptor with a distinct expression pattern.";
EMBO J. 10:1347-1354(1991).
[2]
NUCLEOTIDE SEQUENCE.
TISSUE=Mammary gland;
PubMed=7680645 [NCBI, ExPASy, EBI, Israel, Japan]
Ron D., Reich R., Chedid M., Lengel C., Cohen O.E., Chan A.M., Neufeld G., Miki T., Tronick S.R.;
"Fibroblast growth factor receptor 4 is a high affinity receptor for both acidic and basic fibroblast growth factor but not for keratinocyte growth factor.";
J. Biol. Chem. 268:5388-5394(1993).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1007/s003359900703; PubMed=9457674 [NCBI, ExPASy, EBI, Israel, Japan]
Kostrzewa M., Muller U.;
"Genomic structure and complete sequence of the human FGFR4 gene.";
Mamm. Genome 9:131-135(1998).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Muscle;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
NUCLEOTIDE SEQUENCE [MRNA] OF 609-676.
TISSUE=Blood;
PubMed=2247464 [NCBI, ExPASy, EBI, Israel, Japan]
Partanen J., Maekelae T.P., Alitalo R., Lehvaeslaiho H., Alitalo K.;
"Putative tyrosine kinases expressed in K-562 human leukemia cells.";
Proc. Natl. Acad. Sci. U.S.A. 87:8913-8917(1990).
[6]
PROTEIN SEQUENCE OF 22-38.
DOI=10.1110/ps.04682504; PubMed=15340161 [NCBI, ExPASy, EBI, Israel, Japan]
Zhang Z., Henzel W.J.;
"Signal peptide prediction based on analysis of experimentally verified cleavage sites.";
Protein Sci. 13:2819-2824(2004).
[7]
VARIANTS [LARGE SCALE ANALYSIS] ILE-10; LEU-136; ALA-179 AND ASN-516.
DOI=10.1038/nature05610; PubMed=17344846 [NCBI, ExPASy, EBI, Israel, Japan]
Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G., Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.;
"Patterns of somatic mutation in human cancer genomes.";
Nature 446:153-158(2007).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X57205; CAA40490.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L03840; AAB59389.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
Y13901; CAA74200.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC011847; AAH11847.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M59373; AAA63208.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S15345; TVHUF4.
RefSeq NP_002002.3; -.
NP_075252.2; -.
NP_998812.1; -.
UniGene Hs.165950
3D structure databases
PDB
1QCT; Model; -; B/E=36-353.[ExPASy / RCSB / EBI]
PDBsum 1QCT; -.
SMR P22455; 144-352, 453-747.
ModBase P22455.
Protein-protein interaction databases
DIP DIP:5149N; -.
PTM databases
PhosphoSite P22455; -.
Enzyme and pathway databases
Reactome REACT_9470; Signaling by FGFR.
Organism-specific databases
H-InvDB HIX0005452; -.
HGNC HGNC:3691; FGFR4.
GeneLynx FGFR4; Homo sapiens.
GenAtlas FGFR4.
HPA CAB005196; -.
MIM 134935; gene. [NCBI / EBI]
PharmGKB PA28130; -.
GeneCards P22455.
Gene expression databases
ArrayExpress P22455; -.
CleanEx HS_FGFR4; -.
GermOnline ENSG00000160867; Homo sapiens.
Ontologies
GO
GO:0005887; Cellular component: integral to plasma membrane (traceable author statement from ProtInc).
GO:0005007; Molecular function: fibroblast growth factor receptor activity (traceable author statement from ProtInc).
GO:0008543; Biological process: fibroblast growth factor receptor signaling pathway (traceable author statement from ProtInc).
QuickGo view.
Family and domain databases
InterPro IPR016248; Fibroblast_GF_rcpt.
IPR013151; Ig.
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003598; Ig_sub2.
IPR000719; Prot_kinase_core.
IPR017441; Protein_kinase_ATP_bd_CS.
IPR001245; Tyr_pkinase.
IPR008266; Tyr_pkinase_AS.
Graphical view of domain structure.
Gene3D G3DSA:2.60.40.10; Ig-like_fold; 3.
Pfam PF07679; I-set; 1.
PF00047; ig; 2.
PF07714; Pkinase_Tyr; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000628; FGFR; 1.
PRINTS PR00109; TYRKINASE.
ProDom PD000001; Prot_kinase; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00408; IGc2; 3.
SM00219; TyrKc; 1.
SMART graphical view of domain structure.
PROSITE PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS P22455.
Genome annotation databases
Ensembl ENSG00000160867; Homo sapiens. [Contig view]
GeneID 2264; -.
KEGG hsa:2264; -.
Phylogenomic databases
HOVERGEN P22455; -.
Other
DrugBank DB00039; Palifermin.
LinkHub P22455; -.
SOURCE FGFR4; Homo sapiens.
ProtoNet P22455.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; ATP-binding; Direct protein sequencing; Glycoprotein; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Polymorphism; Receptor; Repeat; Signal; Transferase; Transmembrane; Tyrosine-protein kinase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    21  21      
CHAIN   22   802  781     Fibroblast growth factor receptor 4. PRO_0000016787
TOPO_DOM   22   369  348     Extracellular (Potential). 
TRANSMEM   370   390  21     Potential. 
TOPO_DOM   391   802  412     Cytoplasmic (Potential). 
DOMAIN   22   118  97     Ig-like C2-type 1. 
DOMAIN   152   240  89     Ig-like C2-type 2. 
DOMAIN   249   349  101     Ig-like C2-type 3. 
DOMAIN   467   755  289     Protein kinase. 
NP_BIND   473   481  9     ATP (By similarity). 
ACT_SITE   612   612        Proton acceptor (By similarity). 
BINDING   503   503        ATP (By similarity). 
MOD_RES   643   643        Phosphotyrosine; by autocatalysis (By similarity). 
CARBOHYD   112   112        N-linked (GlcNAc...) (Potential). 
CARBOHYD   258   258        N-linked (GlcNAc...) (Potential). 
CARBOHYD   290   290        N-linked (GlcNAc...) (Potential). 
CARBOHYD   311   311        N-linked (GlcNAc...) (Potential). 
CARBOHYD   322   322        N-linked (GlcNAc...) (Potential). 
DISULFID   57   101        Potential. 
DISULFID   172   224        Potential. 
DISULFID   271   333        Potential. 
VARIANT   10    10  1     V -> I (in dbSNP:rs1966265 [NCBI]). VAR_029185 
VARIANT   136   136  1     P -> L. VAR_042211 
VARIANT   179   179  1     T -> A. VAR_042212 
VARIANT   388   388  1     G -> R (in dbSNP:rs351855 [NCBI]). VAR_014797 
VARIANT   516   516  1     D -> N. VAR_042213 [3D]
CONFLICT   297   297        D -> V (in Ref. 1; CAA40490). 
STRAND   45    47  3      
STRAND   65    67  3      
STRAND   75    81  7      
HELIX   93    95  3      
STRAND   100   102  3      
STRAND   114   116  3      
STRAND   160   163  4      
STRAND   168   171  4      
TURN   176   178  3      
TURN   180   183  4      
STRAND   189   191  3      
TURN   192   194  3      
STRAND   199   205  7      
STRAND   208   213  6      
HELIX   216   218  3      
STRAND   220   227  8      
STRAND   229   242  14      
STRAND   256   260  5      
STRAND   263   265  3      
STRAND   267   271  5      
STRAND   273   275  3      
STRAND   277   285  9      
STRAND   295   298  4      
STRAND   301   304  4      
STRAND   312   322  11      
HELIX   325   327  3      
STRAND   331   336  6      
STRAND   342   349  8      
Sequence information
Length: 802 AA [This is the length of the unprocessed precursor] Molecular weight: 87954 Da [This is the MW of the unprocessed precursor] CRC64: B22B259831BB889F [This is a checksum on the sequence]
        10         20         30         40         50         60 
MRLLLALLGV LLSVPGPPVL SLEASEEVEL EPCLAPSLEQ QEQELTVALG QPVRLCCGRA 

        70         80         90        100        110        120 
ERGGHWYKEG SRLAPAGRVR GWRGRLEIAS FLPEDAGRYL CLARGSMIVL QNLTLITGDS 

       130        140        150        160        170        180 
LTSSNDDEDP KSHRDPSNRH SYPQQAPYWT HPQRMEKKLH AVPAGNTVKF RCPAAGNPTP 

       190        200        210        220        230        240 
TIRWLKDGQA FHGENRIGGI RLRHQHWSLV MESVVPSDRG TYTCLVENAV GSIRYNYLLD 

       250        260        270        280        290        300 
VLERSPHRPI LQAGLPANTT AVVGSDVELL CKVYSDAQPH IQWLKHIVIN GSSFGADGFP 

       310        320        330        340        350        360 
YVQVLKTADI NSSEVEVLYL RNVSAEDAGE YTCLAGNSIG LSYQSAWLTV LPEEDPTWTA 

       370        380        390        400        410        420 
AAPEARYTDI ILYASGSLAL AVLLLLAGLY RGQALHGRHP RPPATVQKLS RFPLARQFSL 

       430        440        450        460        470        480 
ESGSSGKSSS SLVRGVRLSS SGPALLAGLV SLDLPLDPLW EFPRDRLVLG KPLGEGCFGQ 

       490        500        510        520        530        540 
VVRAEAFGMD PARPDQASTV AVKMLKDNAS DKDLADLVSE MEVMKLIGRH KNIINLLGVC 

       550        560        570        580        590        600 
TQEGPLYVIV ECAAKGNLRE FLRARRPPGP DLSPDGPRSS EGPLSFPVLV SCAYQVARGM 

       610        620        630        640        650        660 
QYLESRKCIH RDLAARNVLV TEDNVMKIAD FGLARGVHHI DYYKKTSNGR LPVKWMAPEA 

       670        680        690        700        710        720 
LFDRVYTHQS DVWSFGILLW EIFTLGGSPY PGIPVEELFS LLREGHRMDR PPHCPPELYG 

       730        740        750        760        770        780 
LMRECWHAAP SQRPTFKQLV EALDKVLLAV SEEYLDLRLT FGPYSPSGGD ASSTCSSSDS 

       790        800 
VFSHDPLPLG SSSFPFGSGV QT 

P22455 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA)
Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
 Hosted by ca flag CBR Canada Mirror sites: Australia  Brazil  China  Korea  Switzerland
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!