ID   FGF7_HUMAN              Reviewed;         194 AA.
AC   P21781;
DT   01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1991, sequence version 1.
DT   22-JUL-2008, entry version 78.
DE   RecName: Full=Keratinocyte growth factor;
DE            Short=KGF;
DE   AltName: Full=Fibroblast growth factor 7;
DE            Short=FGF-7;
DE   AltName: Full=Heparin-binding growth factor 7;
DE            Short=HBGF-7;
DE   Flags: Precursor;
GN   Name=FGF7; Synonyms=KGF;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 32-50.
RX   MEDLINE=89368897; PubMed=2475908;
RA   Finch P.W., Rubin J.S., Miki T., Ron D., Aaronson S.A.;
RT   "Human KGF is FGF-related with properties of a paracrine effector of
RT   epithelial cell growth.";
RL   Science 245:752-755(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=92152720; PubMed=1664700;
RA   Aaronson S.A., Bottaro D.P., Miki T., Ron D., Finch P.W.,
RA   Fleming T.P., Ahn J., Taylor W.G., Rubin J.S.;
RT   "Keratinocyte growth factor. A fibroblast growth factor family member
RT   with unusual target cell specificity.";
RL   Ann. N. Y. Acad. Sci. 638:62-77(1991).
RN   [3]
RP   PROTEIN SEQUENCE OF 32-44.
RX   MEDLINE=89128865; PubMed=2915979;
RA   Rubin J.S., Osada H., Finch P.W., Taylor W.G., Rudikoff S.,
RA   Aaronson S.A.;
RT   "Purification and characterization of a newly identified growth factor
RT   specific for epithelial cells.";
RL   Proc. Natl. Acad. Sci. U.S.A. 86:802-806(1989).
RN   [4]
RP   INTERACTION WITH FGFBP1.
RX   PubMed=15806171; DOI=10.1038/sj.onc.1208560;
RA   Beer H.-D., Bittner M., Niklaus G., Munding C., Max N., Goppelt A.,
RA   Werner S.;
RT   "The fibroblast growth factor binding protein is a novel interaction
RT   partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity:
RT   implications for epithelial repair.";
RL   Oncogene 24:5269-5277(2005).
CC   -!- FUNCTION: Growth factor active on keratinocytes. Possible major
CC       paracrine effector of normal epithelial cell proliferation.
CC   -!- SUBUNIT: Interacts with FGFBP1.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Epithelial cell.
CC   -!- SIMILARITY: Belongs to the heparin-binding growth factors family.
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DR   EMBL; M60828; AAA63210.1; -; mRNA.
DR   EMBL; S81661; AAB21431.1; -; mRNA.
DR   PIR; A36301; A36301.
DR   PIR; B46289; B46289.
DR   RefSeq; NP_002000.1; -.
DR   UniGene; Hs.567268; -.
DR   HSSP; Q02195; 1QQK.
DR   SMR; P21781; 63-194.
DR   DIP; DIP:4010N; -.
DR   Ensembl; ENSG00000140285; Homo sapiens.
DR   GeneID; 2252; -.
DR   KEGG; hsa:2252; -.
DR   H-InvDB; HIX0008074; -.
DR   H-InvDB; HIX0012227; -.
DR   H-InvDB; HIX0035058; -.
DR   H-InvDB; HIX0041064; -.
DR   H-InvDB; HIX0058650; -.
DR   H-InvDB; HIX0058651; -.
DR   H-InvDB; HIX0058652; -.
DR   HGNC; HGNC:3685; FGF7.
DR   MIM; 148180; gene.
DR   PharmGKB; PA28124; -.
DR   HOGENOM; P21781; -.
DR   HOVERGEN; P21781; -.
DR   Reactome; REACT_9470; Signaling by FGFR.
DR   DrugBank; DB00039; Palifermin.
DR   LinkHub; P21781; -.
DR   ArrayExpress; P21781; -.
DR   CleanEx; HS_FGF7; -.
DR   GermOnline; ENSG00000140285; Homo sapiens.
DR   GO; GO:0005576; C:extracellular region; EXP:Reactome.
DR   GO; GO:0008083; F:growth factor activity; TAS:ProtInc.
DR   GO; GO:0008544; P:epidermis development; TAS:ProtInc.
DR   GO; GO:0008543; P:fibroblast growth factor receptor signaling...; EXP:Reactome.
DR   GO; GO:0008284; P:positive regulation of cell proliferation; TAS:ProtInc.
DR   GO; GO:0009611; P:response to wounding; TAS:ProtInc.
DR   InterPro; IPR002209; GF_heparin_bd.
DR   InterPro; IPR002348; IL1_HBGF.
DR   PANTHER; PTHR11486; IL1_HBGF; 1.
DR   Pfam; PF00167; FGF; 1.
DR   PRINTS; PR00263; HBGFFGF.
DR   PRINTS; PR00262; IL1HBGF.
DR   ProDom; PD000831; IL1_HBGF; 1.
DR   SMART; SM00442; FGF; 1.
DR   PROSITE; PS00247; HBGF_FGF; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Glycoprotein; Growth factor; Mitogen;
KW   Secreted; Signal.
FT   SIGNAL        1     31
FT   CHAIN        32    194       Keratinocyte growth factor.
FT                                /FTId=PRO_0000008965.
FT   CARBOHYD     45     45       N-linked (GlcNAc...) (Potential).
SQ   SEQUENCE   194 AA;  22509 MW;  B19192474E6049E2 CRC64;
     MHKWILTWIL PTLLYRSCFH IICLVGTISL ACNDMTPEQM ATNVNCSSPE RHTRSYDYME
     GGDIRVRRLF CRTQWYLRID KRGKVKGTQE MKNNYNIMEI RTVAVGIVAI KGVESEFYLA
     MNKEGKLYAK KECNEDCNFK ELILENHYNT YASAKWTHNG GEMFVALNQK GIPVRGKKTK
     KEQKTAHFLP MAIT
//