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UniProtKB/Swiss-Prot entry P21115

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name VB05_VACCC
Primary accession number P21115
Secondary accession numbers None
Integrated into Swiss-Prot on February 1, 1991
Sequence was last modified on February 1, 1991 (Sequence version 1)
Annotations were last modified on    June 16, 2009 (Entry version 56)
Name and origin of the protein
Protein name Plaque-size/host range protein [Precursor]
Synonym Protein B5
Gene name
Name: PS/HR
ORFNames: B5R
From
Vaccinia virus (strain Copenhagen) (VACV) [TaxID: 10249] 
Taxonomy Viruses; dsDNA viruses, no RNA stage; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
Virus host Homo sapiens (Human) [TaxID: 9606]
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1016/0042-6822(90)90294-2; PubMed=2219722 [NCBI, ExPASy, EBI, Israel, Japan]
Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P., Paoletti E.;
"The complete DNA sequence of vaccinia virus.";
Virology 179:247-266(1990).
[2]
 COMPLETE GENOME.
Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P., Paoletti E.;
"Appendix to 'The complete DNA sequence of vaccinia virus'.";
Virology 179:517-563(1990).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M35027; AAA48201.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR D42526; D42526.
3D structure databases
HSSP P10998; 1VVD. [HSSP ENTRY / PDB]
ModBase P21115.
Ontologies
GO
GO:0016021; Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0001848; Molecular function: complement binding (inferred from electronic annotation from InterPro).
GO:0045916; Biological process: negative regulation of complement activation (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR011176; CIP_VAC_C3L.
IPR016060; Complement_control_module.
IPR000436; Sushi_SCR_CCP.
Graphical view of domain structure.
Gene3D G3DSA:2.10.70.10; Complement_control_module; 2.
Pfam PF00084; Sushi; 3.
Pfam graphical view of domain structure.
PIRSF PIRSF002486; CIP_VAC_C3L; 1.
SMART SM00032; CCP; 4.
SMART graphical view of domain structure.
PROSITE PS50923; SUSHI; 3.
PROSITE graphical view of domain structure (profiles).
Other
ProtoNet P21115.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Disulfide bond; Membrane; Repeat; Signal; Sushi; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    17  17     Potential. 
CHAIN   18   317  300     Plaque-size/host range protein. PRO_0000006017
TOPO_DOM   18   279  262     Extracellular (Potential). 
TRANSMEM   280   300  21     Potential. 
TOPO_DOM   301   317  17     Cytoplasmic (Potential). 
DOMAIN   19    74  56     Sushi 1. 
DOMAIN   75   126  52     Sushi 2. 
DOMAIN   127   184  58     Sushi 3. 
DOMAIN   185   239  55     Sushi 4. 
DISULFID   21    61        By similarity. 
DISULFID   48    72        By similarity. 
DISULFID   76   110        By similarity. 
DISULFID   101   125        By similarity. 
DISULFID   130   171        By similarity. 
DISULFID   157   182        By similarity. 
DISULFID   186   225        By similarity. 
DISULFID   211   237        By similarity. 
Sequence information
Length: 317 AA [This is the length of the unprocessed precursor] Molecular weight: 35109 Da [This is the MW of the unprocessed precursor] CRC64: B66E3E29EF3C2BA7 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MKTISVVTLL CVLPAVVYST CTVPTMNNAK LTSTETSFNN NQKVTFTCDQ GYHSSDPNAV 

        70         80         90        100        110        120 
CETDKWKYEN PCKKMCTVSD YISELYNKPL YEVNSTMTLS CNGETKYFRC EEKNGNTSWN 

       130        140        150        160        170        180 
DTVTCPNAEC QPLQLEHGSC QPVKEKYSFG EYMTINCDVG YEVIGASYIS CTANSWNVIP 

       190        200        210        220        230        240 
SCQQKCDIPS LSNGLISGST FSIGGVIHLS CKSGFILTGS PSSTCIDGKW NPVLPICVRT 

       250        260        270        280        290        300 
NEEFDPVDDG PDDETDLSKL SKDVVQYEQE IESLEATYHI IIVALTIMGV IFLISVIVLV 

       310 
CSCDKNNDQY KFHKLLP
P21115 in FASTA format

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