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UniProtKB/Swiss-Prot entry P20783


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name NTF3_HUMAN
Primary accession number P20783
Secondary accession number Q6FH50
Integrated into Swiss-Prot on February 1, 1991
Sequence was last modified on February 1, 1991 (Sequence version 1)
Annotations were last modified on    June 16, 2009 (Entry version 104)
Name and origin of the protein
Protein name Neurotrophin-3 [Precursor]
Synonyms NT-3
Neurotrophic factor
HDNF
Nerve growth factor 2
NGF-2
Gene name
Name: NTF3
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1016/0014-5793(90)81536-W; PubMed=2365067 [NCBI, ExPASy, EBI, Israel, Japan]
Kaisho Y., Yoshimura K., Nakahama K.;
"Cloning and expression of a cDNA encoding a novel human neurotrophic factor.";
FEBS Lett. 266:187-191(1990).
[2]
NUCLEOTIDE SEQUENCE.
DOI=10.1016/0896-6273(90)90203-R; PubMed=2344409 [NCBI, ExPASy, EBI, Israel, Japan]
Rosenthal A., Goeddel D.V., Nguyen T., Lewis M., Shih A., Laramee G.R., Nikolics K., Winslow J.W.;
"Primary structure and biological activity of a novel human neurotrophic factor.";
Neuron 4:767-773(1990).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1073/pnas.87.20.8060; PubMed=2236018 [NCBI, ExPASy, EBI, Israel, Japan]
Jones K.R., Reichardt L.F.;
"Molecular cloning of a human gene that is a member of the nerve growth factor family.";
Proc. Natl. Acad. Sci. U.S.A. 87:8060-8064(1990).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1016/0888-7543(91)90436-I; PubMed=1889806 [NCBI, ExPASy, EBI, Israel, Japan]
Maisonpierre P.C., le Beau M.M., Espinosa R. III, Ip N.Y., Belluscio L., de la Monte S.M., Squinto S., Furth M.E., Yancopoulos G.D.;
"Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations.";
Genomics 10:558-568(1991).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.;
"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201).";
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[8]
NUCLEOTIDE SEQUENCE OF 194-236.
TISSUE=Leukocyte;
DOI=10.1016/0896-6273(91)90180-8; PubMed=2025430 [NCBI, ExPASy, EBI, Israel, Japan]
Hallboeoek F., Ibanez C.F., Persson H.;
"Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary.";
Neuron 6:845-858(1991).
[9]
X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS).
DOI=10.1021/bi00013a001; PubMed=7703225 [NCBI, ExPASy, EBI, Israel, Japan]
Robinson R.C., Radziejewski C., Stuart D.I., Jones E.Y.;
"Structure of the brain-derived neurotrophic factor/neurotrophin 3 heterodimer.";
Biochemistry 34:4139-4146(1995).
[10]
VARIANT GLU-76.
DOI=10.1006/bbrc.1995.1531; PubMed=7733919 [NCBI, ExPASy, EBI, Israel, Japan]
Hattori M., Nanko S.;
"Association of neurotrophin-3 gene variant with severe forms of schizophrenia.";
Biochem. Biophys. Res. Commun. 209:513-518(1995).
[11]
VARIANT GLU-76.
PubMed=8925252 [NCBI, ExPASy, EBI, Israel, Japan]
Arinami T., Takekoshi K., Itokawa M., Hamaguchi H., Toru M.;
"Failure to find associations of the CA repeat polymorphism in the first intron and the Gly-63/Glu-63 polymorphism of the neurotrophin-3 gene with schizophrenia.";
Psychiatr. Genet. 6:13-15(1996).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X53655; CAA37703.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M37763; AAA59953.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M61180; AAA63231.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
CR541906; CAG46704.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
CH471116; EAW88824.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC069773; AAH69773.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC107075; AAI07076.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00025474; -.
PIR A36208; C40304.
RefSeq NP_001096124.1; -.
NP_002518.1; -.
UniGene Hs.99171
3D structure databases
PDB
1B8K; X-ray; 2.15 A; A=139-257.[ExPASy / RCSB / EBI]
1BND; X-ray; 2.30 A; B=139-257.[ExPASy / RCSB / EBI]
1NT3; X-ray; 2.40 A; A=139-257.[ExPASy / RCSB / EBI]
3BUK; X-ray; 2.60 A; A/B=139-257.[ExPASy / RCSB / EBI]
Detailed list of linked structures.
PDBsum 1B8K; -.
1BND; -.
1NT3; -.
3BUK; -.
ModBase P20783.
Protein-protein interaction databases
DIP DIP:346N; -.
IntAct P20783; 1.
Enzyme and pathway databases
Pathway_Interaction_DB trkrpathway; Neurotrophic factor-mediated Trk receptor signaling.
p75ntrpathway; p75(NTR)-mediated signaling.
mapktrkpathway; Trk receptor signaling mediated by the MAPK pathway.
Organism-specific databases
GeneCards GC12P005473; -.
HGNC HGNC:8023; NTF3.
GenAtlas NTF3.
MIM 162660; gene. [NCBI / EBI]
PharmGKB PA31806; -.
Gene expression databases
ArrayExpress P20783; -.
Bgee P20783; -.
CleanEx HS_NTF3; -.
GermOnline ENSG00000185652; Homo sapiens.
Ontologies
GO
GO:0005576; Cellular component: extracellular region (inferred from electronic annotation from UniProtKB-SubCell).
GO:0008083; Molecular function: growth factor activity (inferred from electronic annotation from UniProtKB-KW).
GO:0005165; Molecular function: neurotrophin receptor binding (inferred from electronic annotation from InterPro).
GO:0007165; Biological process: signal transduction (traceable author statement from ProtInc).
QuickGo view.
Family and domain databases
InterPro IPR002072; Nerve_growth_factor-rel.
IPR019846; Nerve_growth_factor_CS.
IPR015578; Neurotrophin-3.
Graphical view of domain structure.
PANTHER PTHR11589:SF4; Neurotrophin-3; 1.
PTHR11589; NGF; 1.
Pfam PF00243; NGF; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF001789; NGF; 1.
PRINTS PR00268; NGF.
ProDom PD002052; NGF; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00140; NGF; 1.
SMART graphical view of domain structure.
PROSITE PS00248; NGF_1; 1.
PS50270; NGF_2; 1.
PROSITE graphical view of domain structure (profiles).
Proteomic databases
PRIDE P20783; -.
Genome annotation databases
Ensembl ENSG00000185652; Homo sapiens. [Contig view]
GeneID 4908; -.
KEGG hsa:4908; -.
Phylogenomic databases
HOGENOM P20783; -.
HOVERGEN P20783; -.
OMA P20783; QRRYSSP.
Other
NextBio 18887; -.
PMAP-CutDB P20783; -.
SOURCE NTF3; Homo sapiens.
ProtoNet P20783.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Cleavage on pair of basic residues; Disulfide bond; Glycoprotein; Growth factor; Polymorphism; Secreted; Signal.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    18  18     Potential. 
PROPEP   19   138  120      PRO_0000019659
CHAIN   139   257  119     Neurotrophin-3. PRO_0000019660
CARBOHYD   131   131        N-linked (GlcNAc...) (Potential). 
DISULFID   152   217         
DISULFID   195   246         
DISULFID   205   248         
VARIANT   76    76  1     G -> E (in dbSNP:rs1805149 [NCBI]). VAR_012084 
STRAND   150   152  3      
STRAND   154   159  6      
STRAND   164   167  4      
STRAND   172   175  4      
STRAND   190   195  6      
STRAND   216   233  18      
STRAND   236   249  14      
Sequence information
Length: 257 AA [This is the length of the unprocessed precursor] Molecular weight: 29355 Da [This is the MW of the unprocessed precursor] CRC64: 39A5BB3B28E25E03 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MSILFYVIFL AYLRGIQGNN MDQRSLPEDS LNSLIIKLIQ ADILKNKLSK QMVDVKENYQ 

        70         80         90        100        110        120 
STLPKAEAPR EPERGGPAKS AFQPVIAMDT ELLRQQRRYN SPRVLLSDST PLEPPPLYLM 

       130        140        150        160        170        180 
EDYVGSPVVA NRTSRRKRYA EHKSHRGEYS VCDSESLWVT DKSSAIDIRG HQVTVLGEIK 

       190        200        210        220        230        240 
TGNSPVKQYF YETRCKEARP VKNGCRGIDD KHWNSQCKTS QTYVRALTSE NNKLVGWRWI 

       250 
RIDTSCVCAL SRKIGRT 

P20783 in FASTA format

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