[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. DOI=10.1038/344339a0; PubMed=2314473 [NCBI, ExPASy, EBI, Israel, Japan] Hohn A., Leibrock J., Bailey K., Barde Y.-A.; "Identification and characterization of a novel member of the nerve growth factor/brain-derived neurotrophic factor family."; Nature 344:339-341(1990).
[2]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. STRAIN=C57BL/6J; TISSUE=Mammary gland; DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan] The MGC Project Team; "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."; Genome Res. 14:2121-2127(2004).
[3]	PROTEIN SEQUENCE OF 140-152. PubMed=7957235 [NCBI, ExPASy, EBI, Israel, Japan] Kolbeck R., Jungbluth S., Barde Y.-A.; "Characterisation of neurotrophin dimers and monomers."; Eur. J. Biochem. 225:995-1003(1994).

Comments

FUNCTION: Seems to promotes the survival of visceral and proprioceptive sensory neurons.
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Brain and peripheral tissues.
SIMILARITY: Belongs to the NGF-beta family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

X53257; CAA37348.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC065785; AAH65785.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

S09155; S09155.

NP_032768.1; -.

3D structure databases

HSSP

P20783; 1NT3. [HSSP ENTRY / PDB]

SMR

P20181; 147-254.

ModBase

P20181.

Protein-protein interaction databases

DIP

DIP:5721N; -.

Organism-specific databases

MGI

MGI:97380; Ntf3.

Gene expression databases

ArrayExpress

P20181; -.

CleanEx

MM_NTF3; -.

GermOnline

ENSMUSG00000049107; Mus musculus.

Ontologies

GO:0016023;	Cellular component: cytoplasmic membrane-bounded vesicle (inferred from direct assay from MGI).
GO:0005788;	Cellular component: endoplasmic reticulum lumen (inferred from experiment from Reactome).
GO:0005166;	Molecular function: neurotrophin p75 receptor binding (traceable author statement from MGI).
GO:0007411;	Biological process: axon guidance (inferred from direct assay from MGI).
GO:0007420;	Biological process: brain development (inferred from mutant phenotype from MGI).
GO:0048484;	Biological process: enteric nervous system development (inferred from mutant phenotype from MGI).
GO:0008544;	Biological process: epidermis development (inferred from mutant phenotype from MGI).
GO:0007403;	Biological process: glial cell fate determination (inferred from mutant phenotype from MGI).
GO:0042490;	Biological process: mechanoreceptor differentiation (inferred from genetic interaction from MGI).
GO:0021675;	Biological process: nerve development (inferred from mutant phenotype from MGI).
GO:0007274;	Biological process: neuromuscular synaptic transmission (inferred from direct assay from MGI).
GO:0007422;	Biological process: peripheral nervous system development (inferred from mutant phenotype from MGI).
GO:0045944;	Biological process: positive regulation of transcription from RNA polymerase II promoter (inferred from direct assay from MGI).
GO:0043523;	Biological process: regulation of neuron apoptosis (inferred from direct assay from MGI).
GO:0051145;	Biological process: smooth muscle cell differentiation (inferred from mutant phenotype from MGI).
QuickGo view.

Family and domain databases

InterPro

IPR015578; Neurotrophin-3.
IPR002072; NGF.
Graphical view of domain structure.

PANTHER

PTHR11589:SF4; Neurotrophin-3; 1.
PTHR11589; NGF; 1.

Pfam

PF00243; NGF; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF001789; NGF; 1.

PRINTS

PR00268; NGF.

ProDom

PD002052; NGF; 1.
[Domain structure / List of seq. sharing at least 1 domain]

SMART

SM00140; NGF; 1.
SMART graphical view of domain structure.

PROSITE

PS00248; NGF_1; 1.
PS50270; NGF_2; 1.
PROSITE graphical view of domain structure (profiles).

BLOCKS

P20181.

Genome annotation databases

Ensembl

ENSMUSG00000049107; Mus musculus. [Contig view]

GeneID

18205; -.

KEGG

mmu:18205; -.

Phylogenomic databases

HOVERGEN

P20181; -.

Other

Ntf3; Mus musculus.

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cleavage on pair of basic residues; Direct protein sequencing; Glycoprotein; Growth factor; Secreted; Signal.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 18`	`18`	`Potential.`
`PROPEP`	`19 139`	`121`		`PRO_0000019661`
`CHAIN`	`140 258`	`119`	`Neurotrophin-3.`	`PRO_0000019662`
`CARBOHYD`	`131 131`		`N-linked (GlcNAc...) (Potential).`
`DISULFID`	`153 218`		`By similarity.`
`DISULFID`	`196 247`		`By similarity.`
`DISULFID`	`206 249`		`By similarity.`

Sequence information

Length: 258 AA [This is the length of the unprocessed precursor]

Molecular weight: 29588 Da [This is the MW of the unprocessed precursor]

CRC64: 7180D064E8AE6042 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSILFYVIFL AYLRGIQGNS MDQRSLPEDS LNSLIIKLIQ ADILKNKLSK QMVDVKENYQ 

        70         80         90        100        110        120 
STLPKAEAPR EPEQGEATRS EFQPMIATDT ELLRQQRRYN SPRVLLSDST PLEPPPLYLM 

       130        140        150        160        170        180 
EDYVGNPVVA NRTSPRRKRY AEHKSHRGEY SVCDSESLWV TDKSSAIDIR GHQVTVLGEI 

       190        200        210        220        230        240 
KTGNSPVKQY FYETRCKEAR PVKNGCRGID DKHWNSQCKT SQTYVRALTS ENNKLVGWRW 

       250 
IRIDTSCVCA LSRKIGRT

P20181 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools