[1]	NUCLEOTIDE SEQUENCE [MRNA]. DOI=10.1084/jem.171.5.1393; PubMed=1692078 [NCBI, ExPASy, EBI, Israel, Japan] Triebel F., Jitsukawa S., Baixeras E., Roman-Roman S., Genevee C., Viegas-Pequignot E., Hercend T.; "LAG-3, a novel lymphocyte activation gene closely related to CD4."; J. Exp. Med. 171:1393-1405(1990).
[2]	SEQUENCE REVISION TO C-TERMINUS. Triebel F.; Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases.
[3]	CHARACTERIZATION. DOI=10.1084/jem.176.2.327; PubMed=1380059 [NCBI, ExPASy, EBI, Israel, Japan] Baixeras E., Huard B., Miossec C., Jitsukawa S., Martin M., Hercend T., Auffray C., Triebel F., Piatier-Tonneau D.; "Characterization of the lymphocyte activation gene 3-encoded protein. A new ligand for human leukocyte antigen class II antigens."; J. Exp. Med. 176:327-337(1992).

Comments

FUNCTION: Involved in lymphocyte activation. Binds to HLA class-II antigens.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
TISSUE SPECIFICITY: On cell surface of activated NK and T-lymphocytes.
SIMILARITY: Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
SIMILARITY: Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

X51985; CAA36243.3; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

IPI00000881; -.

S11246; S11246.

NP_002277.4; -.

3D structure databases

ModBase

P18627.

Organism-specific databases

GC12P006751; -.

HIX0026391; -.

HGNC:6476; LAG3.

CAB002301; -.
HPA013967; -.

MIM

153337; gene. [NCBI / EBI]

PharmGKB

PA30265; -.

Gene expression databases

P18627; -.

P18627; -.

HS_LAG3; -.

ENSG00000089692; Homo sapiens.

Ontologies

GO:0016021;	Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0003823;	Molecular function: antigen binding (traceable author statement from ProtInc).
GO:0042289;	Molecular function: MHC class II protein binding (inferred from direct assay from MGI).
QuickGo view.

Family and domain databases

InterPro

IPR013151; Ig.
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR003599; Ig_sub.
IPR013106; Ig_V-set.
IPR015621; IL1-receptor.
Graphical view of domain structure.

Gene3D

G3DSA:2.60.40.10; Ig-like_fold; 1.

PANTHER

PTHR11890; IL1-receptor; 1.

Pfam

PF00047; ig; 1.
PF07686; V-set; 1.
Pfam graphical view of domain structure.

SMART

SM00409; IG; 3.
SMART graphical view of domain structure.

PROSITE

PS50835; IG_LIKE; 2.
PROSITE graphical view of domain structure (profiles).

Proteomic databases

PRIDE

P18627; -.

Genome annotation databases

Ensembl

ENSG00000089692; Homo sapiens. [Contig view]

GeneID

3902; -.

KEGG

hsa:3902; -.

Phylogenomic databases

HOGENOM

P18627; -.

HOVERGEN

P18627; -.

Other

15317; -.

LAG3; Homo sapiens.

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Repeat; Signal; Transmembrane.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 28`	`28`
`CHAIN`	`29 525`	`497`	`Lymphocyte activation gene 3 protein.`	`PRO_0000014631`
`TOPO_DOM`	`29 450`	`422`	`Extracellular (Potential).`
`TRANSMEM`	`451 471`	`21`	`Potential.`
`TOPO_DOM`	`472 525`	`54`	`Cytoplasmic (Potential).`
`DOMAIN`	`37 167`	`131`	`Ig-like V-type.`
`DOMAIN`	`168 252`	`85`	`Ig-like C2-type 1.`
`DOMAIN`	`265 343`	`79`	`Ig-like C2-type 2.`
`DOMAIN`	`348 419`	`72`	`Ig-like C2-type 3.`
`REGION`	`501 524`	`24`	`12 X 2 AA tandem repeats of E-X.`
`CARBOHYD`	`188 188`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`250 250`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`256 256`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`343 343`		`N-linked (GlcNAc...) (Potential).`
`DISULFID`	`44 160`		`Potential.`
`DISULFID`	`189 241`		`Potential.`
`DISULFID`	`282 333`		`Potential.`
`DISULFID`	`369 412`		`Potential.`

Sequence information

Length: 525 AA [This is the length of the unprocessed precursor]

Molecular weight: 57437 Da [This is the MW of the unprocessed precursor]

CRC64: C711EDDB0E9E2733 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MWEAQFLGLL FLQPLWVAPV KPLQPGAEVP VVWAQEGAPA QLPCSPTIPL QDLSLLRRAG 

        70         80         90        100        110        120 
VTWQHQPDSG PPAAAPGHPL APGPHPAAPS SWGPRPRRYT VLSVGPGGLR SGRLPLQPRV 

       130        140        150        160        170        180 
QLDERGRQRG DFSLWLRPAR RADAGEYRAA VHLRDRALSC RLRLRLGQAS MTASPPGSLR 

       190        200        210        220        230        240 
ASDWVILNCS FSRPDRPASV HWFRNRGQGR VPVRESPHHH LAESFLFLPQ VSPMDSGPWG 

       250        260        270        280        290        300 
CILTYRDGFN VSIMYNLTVL GLEPPTPLTV YAGAGSRVGL PCRLPAGVGT RSFLTAKWTP 

       310        320        330        340        350        360 
PGGGPDLLVT GDNGDFTLRL EDVSQAQAGT YTCHIHLQEQ QLNATVTLAI ITVTPKSFGS 

       370        380        390        400        410        420 
PGSLGKLLCE VTPVSGQERF VWSSLDTPSQ RSFSGPWLEA QEAQLLSQPW QCQLYQGERL 

       430        440        450        460        470        480 
LGAAVYFTEL SSPGAQRSGR APGALPAGHL LLFLTLGVLS LLLLVTGAFG FHLWRRQWRP 

       490        500        510        520 
RRFSALEQGI HPPQAQSKIE ELEQEPEPEP EPEPEPEPEP EPEQL

P18627 in FASTA format

View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools