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UniProtKB/Swiss-Prot entry P18280


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name NTF3_RAT
Primary accession number P18280
Secondary accession number Q6NS33
Integrated into Swiss-Prot on November 1, 1990
Sequence was last modified on November 1, 1990 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 69)
Name and origin of the protein
Protein name Neurotrophin-3 [Precursor]
Synonyms NT-3
Neurotrophic factor
HDNF
Nerve growth factor 2
NGF-2
Gene name
Name: Ntf3
Synonyms: Ntf-3
From
Rattus norvegicus (Rat) [TaxID: 10116] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=2164684 [NCBI, ExPASy, EBI, Israel, Japan]
Ernfors P., Ibanez C.F., Ebendal T., Olson L., Persson H.;
"Molecular cloning and neurotrophic activities of a protein with structural similarities to nerve growth factor: developmental and topographical expression in the brain.";
Proc. Natl. Acad. Sci. U.S.A. 87:5454-5458(1990).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=2321006 [NCBI, ExPASy, EBI, Israel, Japan]
Maisonpierre P.C., Belluscio L., Squinto S., Ip N.Y., Furth M.E., Lindsay R.M., Yancopoulos G.D.;
"Neurotrophin-3: a neurotrophic factor related to NGF and BDNF.";
Science 247:1446-1451(1990).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1016/0888-7543(91)90436-I; PubMed=1889806 [NCBI, ExPASy, EBI, Israel, Japan]
Maisonpierre P.C., le Beau M.M., Espinosa R. III, Ip N.Y., Belluscio L., de la Monte S.M., Squinto S., Furth M.E., Yancopoulos G.D.;
"Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations.";
Genomics 10:558-568(1991).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Lung;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
NUCLEOTIDE SEQUENCE OF 195-237.
STRAIN=Sprague-Dawley;
TISSUE=Liver;
DOI=10.1016/0896-6273(91)90180-8; PubMed=2025430 [NCBI, ExPASy, EBI, Israel, Japan]
Hallboeoek F., Ibanez C.F., Persson H.;
"Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary.";
Neuron 6:845-858(1991).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M34643; AAA41313.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M33968; AAA41727.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M61179; AAA63497.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC070504; AAH70504.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A35781; A35781.
RefSeq NP_112335.2; -.
UniGene Rn.9715
3D structure databases
HSSP P20783; 1NT3. [HSSP ENTRY / PDB]
SMR P18280; 147-254.
ModBase P18280.
Organism-specific databases
RGD 619728; Ntf3.
Gene expression databases
ArrayExpress P18280; -.
GermOnline ENSRNOG00000019716; Rattus norvegicus.
Ontologies
GO
GO:0005576; Cellular component: extracellular region (inferred from experiment from Reactome).
QuickGo view.
Family and domain databases
InterPro IPR015578; Neurotrophin-3.
IPR002072; NGF.
Graphical view of domain structure.
PANTHER PTHR11589:SF4; Neurotrophin-3; 1.
PTHR11589; NGF; 1.
Pfam PF00243; NGF; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF001789; NGF; 1.
PRINTS PR00268; NGF.
ProDom PD002052; NGF; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00140; NGF; 1.
SMART graphical view of domain structure.
PROSITE PS00248; NGF_1; 1.
PS50270; NGF_2; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS P18280.
Genome annotation databases
Ensembl ENSRNOG00000019716; Rattus norvegicus. [Contig view]
GeneID 81737; -.
KEGG rno:81737; -.
Phylogenomic databases
HOVERGEN P18280; -.
Other
ProtoNet P18280.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cleavage on pair of basic residues; Glycoprotein; Growth factor; Secreted; Signal.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    18  18     Potential. 
PROPEP   19   139  121      PRO_0000019663
CHAIN   140   258  119     Neurotrophin-3. PRO_0000019664
CARBOHYD   131   131        N-linked (GlcNAc...) (Potential). 
DISULFID   153   218        By similarity. 
DISULFID   196   247        By similarity. 
DISULFID   206   249        By similarity. 
CONFLICT   218   218        C -> R (in Ref. 4; AAH70504). 
Sequence information
Length: 258 AA [This is the length of the unprocessed precursor] Molecular weight: 29645 Da [This is the MW of the unprocessed precursor] CRC64: 74D557CF8518A1CE [This is a checksum on the sequence]
        10         20         30         40         50         60 
MSILFYVIFL AYLRGIQGNN MDQRSLPEDS LNSLIIKLIQ ADILKNKLSK QMVDVKENYQ 

        70         80         90        100        110        120 
STLPKAEAPR EPEQGEATRS EFQPMIATDT ELLRQQRRYN SPRVLLSDST PLEPPPLYLM 

       130        140        150        160        170        180 
EDYVGNPVVT NRTSPRRKRY AEHKSHRGEY SVCDSESLWV TDKSSAIDIR GHQVTVLGEI 

       190        200        210        220        230        240 
KTGNSPVKQY FYETRCKEAR PVKNGCRGID DKHWNSQCKT SQTYVRALTS ENNKLVGWRW 

       250 
IRIDTSCVCA LSRKIGRT 

P18280 in FASTA format

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BLAST logo BLAST submission on ExPASy/SIB
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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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