[1]	NUCLEOTIDE SEQUENCE [MRNA]. TISSUE=Brain; PubMed=2153106 [NCBI, ExPASy, EBI, Israel, Japan] Shigemoto R., Yokota Y., Tsuchida K., Nakanishi S.; "Cloning and expression of a rat neuromedin K receptor cDNA."; J. Biol. Chem. 265:623-628(1990).

Comments

FUNCTION: This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
PTM: The anchoring of this receptor to the plasma membrane is probably mediated by the palmitoylation of a cysteine residue.
MISCELLANEOUS: The rank order of affinity of this receptor to tachykinins is: neuromedin-K > substance K > substance P.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family [view classification].

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

J05189; AAA41688.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

IPI00210290; -.

A34916; A34916.

NP_058749.1; -.

3D structure databases

HSSP

P02699; 1F88. [HSSP ENTRY / PDB]

ModBase

P16177.

Protein family/group databases

GPCRDB

P16177; NK3R_RAT.

Organism-specific databases

RGD

3810; Tacr3.

Gene expression databases

ArrayExpress

P16177; -.

GermOnline

ENSRNOG00000009372; Rattus norvegicus.

Ontologies

GO:0016021;	Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0005634;	Cellular component: nucleus (inferred from direct assay from RGD).
GO:0005886;	Cellular component: plasma membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0004995;	Molecular function: tachykinin receptor activity (inferred from direct assay from RGD).
GO:0007568;	Biological process: aging (inferred from expression pattern from RGD).
GO:0007186;	Biological process: G-protein coupled receptor protein signaling pathway (inferred from electronic annotation from UniProtKB-KW).
GO:0042538;	Biological process: hyperosmotic salinity response (inferred from direct assay from RGD).
GO:0045777;	Biological process: positive regulation of blood pressure (inferred from direct assay from RGD).
GO:0010460;	Biological process: positive regulation of heart rate (inferred from direct assay from RGD).
GO:0070474;	Biological process: positive regulation of uterine smooth muscle contraction (inferred from direct assay from RGD).
GO:0042053;	Biological process: regulation of dopamine metabolic process (inferred from direct assay from RGD).
GO:0060259;	Biological process: regulation of feeding behavior (inferred from direct assay from RGD).
GO:0042220;	Biological process: response to cocaine (inferred from mutant phenotype from RGD).
GO:0032355;	Biological process: response to estradiol stimulus (inferred from direct assay from RGD).
GO:0043278;	Biological process: response to morphine (inferred from expression pattern from RGD).
QuickGo view.

Family and domain databases

InterPro

IPR000276; 7TM_GPCR_Rhodpsn.
IPR017452; GPCR_Rhodpsn_supfam.
IPR001681; Neurokn_rcpt.
IPR001013; NK3_rcpt.
Graphical view of domain structure.

Pfam

PF00001; 7tm_1; 1.
Pfam graphical view of domain structure.

PRINTS

PR00237; GPCRRHODOPSN.
PR01026; NEUROKININ3R.
PR00244; NEUROKININR.

PROSITE

PS00237; G_PROTEIN_RECEP_F1_1; 1.
PS50262; G_PROTEIN_RECEP_F1_2; 1.
PROSITE graphical view of domain structure (profiles).

Genome annotation databases

Ensembl

ENSRNOG00000009372; Rattus norvegicus. [Contig view]

GeneID

24808; -.

KEGG

rno:24808; -.

Phylogenomic databases

HOVERGEN

P16177; -.

OMA

P16177; RQSSMYT.

Other

604488; -.

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane; Palmitate; Phosphoprotein; Receptor; Transducer; Transmembrane.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 452`	`452`	`Neuromedin-K receptor.`	`PRO_0000069902`
`TOPO_DOM`	`1 71`	`71`	`Extracellular (Potential).`
`TRANSMEM`	`72 94`	`23`	`1 (Potential).`
`TOPO_DOM`	`95 104`	`10`	`Cytoplasmic (Potential).`
`TRANSMEM`	`105 126`	`22`	`2 (Potential).`
`TOPO_DOM`	`127 146`	`20`	`Extracellular (Potential).`
`TRANSMEM`	`147 168`	`22`	`3 (Potential).`
`TOPO_DOM`	`169 188`	`20`	`Cytoplasmic (Potential).`
`TRANSMEM`	`189 209`	`21`	`4 (Potential).`
`TOPO_DOM`	`210 232`	`23`	`Extracellular (Potential).`
`TRANSMEM`	`233 257`	`25`	`5 (Potential).`
`TOPO_DOM`	`258 286`	`29`	`Cytoplasmic (Potential).`
`TRANSMEM`	`287 308`	`22`	`6 (Potential).`
`TOPO_DOM`	`309 321`	`13`	`Extracellular (Potential).`
`TRANSMEM`	`322 346`	`25`	`7 (Potential).`
`TOPO_DOM`	`347 452`	`106`	`Cytoplasmic (Potential).`
`LIPID`	`361 361`		`S-palmitoyl cysteine (Potential).`
`CARBOHYD`	`9 9`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`23 23`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`40 40`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`60 60`		`N-linked (GlcNAc...) (Potential).`
`DISULFID`	`145 220`		`By similarity.`

Sequence information

Length: 452 AA [This is the length of the unprocessed precursor]

Molecular weight: 51107 Da [This is the MW of the unprocessed precursor]

CRC64: 51D8EFC94F34CCAE [This is a checksum on the sequence]

        10         20         30         40         50         60 
MASVPRGENW TDGTVEVGTH TGNLSSALGV TEWLALQAGN FSSALGLPAT TQAPSQVRAN 

        70         80         90        100        110        120 
LTNQFVQPSW RIALWSLAYG LVVAVAVFGN LIVIWIILAH KRMRTVTNYF LVNLAFSDAS 

       130        140        150        160        170        180 
VAAFNTLINF IYGLHSEWYF GANYCRFQNF FPITAVFASI YSMTAIAVDR YMAIIDPLKP 

       190        200        210        220        230        240 
RLSATATKIV IGSIWILAFL LAFPQCLYSK IKVMPGRTLC YVQWPEGPKQ HFTYHIIVII 

       250        260        270        280        290        300 
LVYCFPLLIM GVTYTIVGIT LWGGEIPGDT CDKYHEQLKA KRKVVKMMII VVVTFAICWL 

       310        320        330        340        350        360 
PYHVYFILTA IYQQLNRWKY IQQVYLASFW LAMSSTMYNP IIYCCLNKRF RAGFKRAFRW 

       370        380        390        400        410        420 
CPFIQVSSYD ELELKTTRFH PTRQSSLYTV SRMESVTVLF DPNDGDPTKS SRKKRAVPRD 

       430        440        450 
PSANGCSHRG SKSASTTSSF ISSPYTSVDE YS

P16177 in FASTA format

View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools