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[1]
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NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Kidney;
DOI=10.1021/bi00456a004; PubMed=2340280 [NCBI, ExPASy, EBI, Israel, Japan]
Johnson E.F.,
Walker D.L.,
Griffin K.J.,
Clark J.E.,
Okita R.T.,
Meurhoff A.S.,
Masters B.S.S.;
"Cloning and expression of three rabbit kidney cDNAs encoding lauric acid omega-hydroxylases.";
Biochemistry 29:873-879(1990).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 5-24.
TISSUE=Kidney;
PubMed=2600085 [NCBI, ExPASy, EBI, Israel, Japan]
Yokotani N.,
Bernhardt R.,
Sogawa K.,
Kusunose E.,
Gotoh O.,
Kusunose M.,
Fujii-Kuriyama Y.;
"Two forms of omega-hydroxylase toward prostaglandin A and laurate. cDNA cloning and their expression.";
J. Biol. Chem. 264:21665-21669(1989).
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[3]
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PROTEIN SEQUENCE OF 5-24.
TISSUE=Kidney;
PubMed=2127276 [NCBI, ExPASy, EBI, Israel, Japan]
Yoshimura R.,
Kusunose E.,
Yokotani N.,
Yamamoto S.,
Kubota I.,
Kusunose M.;
"Purification and characterization of two forms of fatty acid omega-hydroxylase cytochrome P-450 from rabbit kidney cortex microsomes.";
J. Biochem. 108:544-548(1990).
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- FUNCTION: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
- FUNCTION: The kidney P-450 system is rather specialized for the omega-hydroxylation of fatty acids. Both P450-KA1 and P450-KA2 catalyze the omega- and (omega-1)-hydroxylation of various fatty acids with no drug-metabolizing activity, and hydroxylate prostaglandin A1 and A2 solely at the omega-position.
- CATALYTIC ACTIVITY: Octane + reduced rubredoxin + O2 = 1-octanol + oxidized rubredoxin + H2O.
- COFACTOR: Heme group (By similarity).
- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
- TISSUE SPECIFICITY: Liver, kidney, small intestine.
- INDUCTION: P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.
- SIMILARITY: Belongs to the cytochrome P450 family.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 511 AA [This is the length of the unprocessed precursor] |
Molecular weight: 58319 Da [This is the MW of the unprocessed precursor] |
CRC64: 21FD8215D26A4451 [This is a checksum on the sequence] |
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10 20 30 40 50 60
MSVSALSSTR LPGSFSGFLQ AAALLGLLLL LLKAAQLYLR RQWLLRALQQ FPCPPSHWLL
70 80 90 100 110 120
GHSREFPIDS ELQQVLKRVE KFPSACPRWL WGSELFLICY DPDYMKTILG RSDPKARVSY
130 140 150 160 170 180
SFLAPWIGYG LLLLEGQTWF QHRRMLTPAF HYDILKPYVG LMVDSVQVML DKLEKLARKD
190 200 210 220 230 240
APLEIYEHVS LMTLETIMKC AFSHQGSVQL ESRTSKSYIQ AVRELSDLAL QRVRNVFHQS
250 260 270 280 290 300
DFLYRLSPEG RLSHRACQLA HEHTDRVIQQ RKAQLQQEGE LEKVRRKRRL DFLDVLLFAK
310 320 330 340 350 360
MENGSSLSDQ DLRAEVDTFM FEGHDTTASG ISWIFYALAT HPEHQHRCRE EIQGLLGDGA
370 380 390 400 410 420
SITWEHLDKM PYTTMCIKEA LRLYPPVPGV GSKLSSPVTF PDGRSLPKGI IITLSIYGLH
430 440 450 460 470 480
HNPKVWPNPE VFDPSRFAPG SARHSHAFLP FSGGSRNCIG KQFAMNELKV AVALTLVRFE
490 500 510
LLPDPTRVPI PITRLVLKSK NGIHLRLRKL H
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P14581 in FASTA format |
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ExPASy Home page
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