ID   FGF5_HUMAN              Reviewed;         268 AA.
AC   P12034; O75846; Q3Y8M3;
DT   01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 4.
DT   22-JUL-2008, entry version 83.
DE   RecName: Full=Fibroblast growth factor 5;
DE            Short=FGF-5;
DE   AltName: Full=Heparin-binding growth factor 5;
DE            Short=HBGF-5;
DE   AltName: Full=Smag-82;
DE   Flags: Precursor;
GN   Name=FGF5;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG).
RC   TISSUE=Brain stem;
RX   MEDLINE=91045929; PubMed=1700424;
RA   Haub O., Drucker B., Goldfarb M.;
RT   "Expression of the murine fibroblast growth factor 5 gene in the adult
RT   central nervous system.";
RL   Proc. Natl. Acad. Sci. U.S.A. 87:8022-8026(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=89096942; PubMed=3211147;
RA   Zhan X., Bates B., Hu X., Goldfarb M.;
RT   "The human FGF-5 oncogene encodes a novel protein related to
RT   fibroblast growth factors.";
RL   Mol. Cell. Biol. 8:3487-3495(1988).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT).
RA   Ozawa K., Suzuki S., Asada M., Tomooka Y., Li A., Yoneda A., Komi A.,
RA   Imamura T.;
RT   "An alternatively-spliced FGF-5 mRNA is abundant in brain and
RT   translates into a partial agonist/antagonist for FGF-5 neurotrophic
RT   activity.";
RL   Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT).
RC   TISSUE=Umbilical artery;
RX   MEDLINE=20379035; PubMed=10823842; DOI=10.1074/jbc.M910099199;
RA   de Vries C.J.M., van Achterberg T.A.E., Horrevoets A.J.G.,
RA   ten Cate J.W., Pannekoek H.;
RT   "Differential display identification of 40 genes with altered
RT   expression in activated human smooth muscle cells. Local expression in
RT   atherosclerotic lesions of smags, smooth muscle activation-specific
RT   genes.";
RL   J. Biol. Chem. 275:23939-23947(2000).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT VAL-54.
RA   Livingston R.J., Rieder M.J., Shaffer T., Bertucci C., Baier C.N.,
RA   Rajkumar N., Willa H.T., Daniels M., Downing T.K., Stanaway I.B.,
RA   Nguyen C.P., Gildersleeve H., Cassidy C.M., Johnson E.J.,
RA   Swanson J.E., McFarland I., Yool B., Park C., Nickerson D.A.;
RT   "NIEHS-SNPs, environmental genome project, NIEHS ES15478, Department
RT   of Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu).";
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Functions as an inhibitor of hair elongation by
CC       promoting progression from anagen, the growth phase of the hair
CC       follicle, into catagen the apoptosis-induced regression phase (By
CC       similarity).
CC   -!- SUBCELLULAR LOCATION: Secreted (Potential).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=Long;
CC         IsoId=P12034-1; Sequence=Displayed;
CC       Name=Short; Synonyms=FGF-5S;
CC         IsoId=P12034-2; Sequence=VSP_001518, VSP_001519;
CC         Note=Seems to have an antagonistic effect compared to that of
CC         the isoform Long;
CC   -!- TISSUE SPECIFICITY: Expressed in neonatal brain.
CC   -!- DEVELOPMENTAL STAGE: Can transform NIH 3T3 cells.
CC   -!- SIMILARITY: Belongs to the heparin-binding growth factors family.
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DR   EMBL; M37825; AAB06463.1; -; mRNA.
DR   EMBL; M23536; AAB60699.1; -; Genomic_DNA.
DR   EMBL; M23534; AAB60699.1; JOINED; Genomic_DNA.
DR   EMBL; M23535; AAB60699.1; JOINED; Genomic_DNA.
DR   EMBL; M23534; AAB60698.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AB016517; BAA33738.1; -; mRNA.
DR   EMBL; AF171928; AAF89742.1; -; mRNA.
DR   EMBL; DQ151636; AAZ67914.1; -; Genomic_DNA.
DR   PIR; A31194; TVHUF5.
DR   PIR; B31194; B31194.
DR   RefSeq; NP_004455.2; -.
DR   RefSeq; NP_149134.1; -.
DR   UniGene; Hs.37055; -.
DR   HSSP; P08620; 1IJT.
DR   DIP; DIP:4018N; -.
DR   Ensembl; ENSG00000138675; Homo sapiens.
DR   GeneID; 2250; -.
DR   KEGG; hsa:2250; -.
DR   HGNC; HGNC:3683; FGF5.
DR   HPA; CAB010313; -.
DR   MIM; 165190; gene.
DR   PharmGKB; PA28122; -.
DR   HOGENOM; P12034; -.
DR   HOVERGEN; P12034; -.
DR   Reactome; REACT_9470; Signaling by FGFR.
DR   ArrayExpress; P12034; -.
DR   CleanEx; HS_FGF5; -.
DR   GermOnline; ENSG00000138675; Homo sapiens.
DR   GO; GO:0005615; C:extracellular space; TAS:ProtInc.
DR   GO; GO:0008283; P:cell proliferation; TAS:ProtInc.
DR   GO; GO:0007267; P:cell-cell signaling; TAS:ProtInc.
DR   GO; GO:0008543; P:fibroblast growth factor receptor signaling...; TAS:ProtInc.
DR   GO; GO:0007399; P:nervous system development; TAS:ProtInc.
DR   InterPro; IPR002209; GF_heparin_bd.
DR   InterPro; IPR002348; IL1_HBGF.
DR   PANTHER; PTHR11486; IL1_HBGF; 1.
DR   Pfam; PF00167; FGF; 1.
DR   PRINTS; PR00263; HBGFFGF.
DR   PRINTS; PR00262; IL1HBGF.
DR   ProDom; PD000831; IL1_HBGF; 1.
DR   SMART; SM00442; FGF; 1.
DR   PROSITE; PS00247; HBGF_FGF; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Glycoprotein; Growth factor; Mitogen;
KW   Polymorphism; Proto-oncogene; Secreted; Signal.
FT   SIGNAL        1     17       Potential.
FT   CHAIN        18    268       Fibroblast growth factor 5.
FT                                /FTId=PRO_0000008958.
FT   COMPBIAS     49     52       Poly-Ser.
FT   COMPBIAS     55     62       Poly-Ser.
FT   CARBOHYD    110    110       N-linked (GlcNAc...) (Potential).
FT   VAR_SEQ     120    123       VLEI -> QVHR (in isoform Short).
FT                                /FTId=VSP_001518.
FT   VAR_SEQ     124    268       Missing (in isoform Short).
FT                                /FTId=VSP_001519.
FT   VARIANT      54     54       M -> V (in dbSNP:rs33950145).
FT                                /FTId=VAR_025174.
FT   CONFLICT     42     42       R -> I (in Ref. 1; AAB06463).
FT   CONFLICT     83     86       PSGR -> LGA (in Ref. 2; AAB60699).
FT   CONFLICT    224    224       Q -> QQ (in Ref. 5; AAZ67914).
FT   CONFLICT    238    238       K -> N (in Ref. 1 and 2).
FT   CONFLICT    245    245       P -> S (in Ref. 1 and 2).
SQ   SEQUENCE   268 AA;  29551 MW;  28B7268B26781BCF CRC64;
     MSLSFLLLLF FSHLILSAWA HGEKRLAPKG QPGPAATDRN PRGSSSRQSS SSAMSSSSAS
     SSPAASLGSQ GSGLEQSSFQ WSPSGRRTGS LYCRVGIGFH LQIYPDGKVN GSHEANMLSV
     LEIFAVSQGI VGIRGVFSNK FLAMSKKGKL HASAKFTDDC KFRERFQENS YNTYASAIHR
     TEKTGREWYV ALNKRGKAKR GCSPRVKPQH ISTHFLPRFK QSEQPELSFT VTVPEKKKPP
     SPIKPKIPLS APRKNTNSVK YRLKFRFG
//