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UniProtKB/Swiss-Prot entry P12034


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name FGF5_HUMAN
Primary accession number P12034
Secondary accession numbers O75846 Q3Y8M3
Integrated into Swiss-Prot on October 1, 1989
Sequence was last modified on January 24, 2006 (Sequence version 4)
Annotations were last modified on    June 10, 2008 (Entry version 82)
Name and origin of the protein
Protein name Fibroblast growth factor 5 [Precursor]
Synonyms FGF-5
HBGF-5
Smag-82
Gene name
Name: FGF5
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG).
TISSUE=Brain stem;
PubMed=1700424 [NCBI, ExPASy, EBI, Israel, Japan]
Haub O., Drucker B., Goldfarb M.;
"Expression of the murine fibroblast growth factor 5 gene in the adult central nervous system.";
Proc. Natl. Acad. Sci. U.S.A. 87:8022-8026(1990).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=3211147 [NCBI, ExPASy, EBI, Israel, Japan]
Zhan X., Bates B., Hu X., Goldfarb M.;
"The human FGF-5 oncogene encodes a novel protein related to fibroblast growth factors.";
Mol. Cell. Biol. 8:3487-3495(1988).
[3]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT).
Ozawa K., Suzuki S., Asada M., Tomooka Y., Li A., Yoneda A., Komi A., Imamura T.;
"An alternatively-spliced FGF-5 mRNA is abundant in brain and translates into a partial agonist/antagonist for FGF-5 neurotrophic activity.";
Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT).
TISSUE=Umbilical artery;
DOI=10.1074/jbc.M910099199; PubMed=10823842 [NCBI, ExPASy, EBI, Israel, Japan]
de Vries C.J.M., van Achterberg T.A.E., Horrevoets A.J.G., ten Cate J.W., Pannekoek H.;
"Differential display identification of 40 genes with altered expression in activated human smooth muscle cells. Local expression in atherosclerotic lesions of smags, smooth muscle activation-specific genes.";
J. Biol. Chem. 275:23939-23947(2000).
[5]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT VAL-54.
Livingston R.J., Rieder M.J., Shaffer T., Bertucci C., Baier C.N., Rajkumar N., Willa H.T., Daniels M., Downing T.K., Stanaway I.B., Nguyen C.P., Gildersleeve H., Cassidy C.M., Johnson E.J., Swanson J.E., McFarland I., Yool B., Park C., Nickerson D.A.;
"NIEHS-SNPs, environmental genome project, NIEHS ES15478, Department of Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu).";
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M37825; AAB06463.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M23536; AAB60699.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M23534; AAB60699.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M23535; AAB60699.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M23534; AAB60698.1; ALT_SEQ; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB016517; BAA33738.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF171928; AAF89742.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
DQ151636; AAZ67914.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A31194; TVHUF5.
B31194; B31194.
RefSeq NP_004455.2; -.
NP_149134.1; -.
UniGene Hs.37055
3D structure databases
HSSP P08620; 1IJT. [HSSP ENTRY / PDB]
ModBase P12034.
Protein-protein interaction databases
DIP DIP:4018N; -.
Enzyme and pathway databases
Reactome REACT_9470; Signaling by FGFR.
Polymorphism databases
NIEHS-SNPs FGF5.
Organism-specific databases
HGNC HGNC:3683; FGF5.
GeneLynx FGF5; Homo sapiens.
GenAtlas FGF5.
MIM 165190; gene. [NCBI / EBI]
PharmGKB PA28122; -.
GeneCards P12034.
Gene expression databases
ArrayExpress P12034; -.
CleanEx HS_FGF5; -.
GermOnline ENSG00000138675; Homo sapiens.
Ontologies
GO
GO:0005615; Cellular component: extracellular space (traceable author statement from ProtInc).
GO:0008283; Biological process: cell proliferation (traceable author statement from ProtInc).
GO:0007267; Biological process: cell-cell signaling (traceable author statement from ProtInc).
GO:0008543; Biological process: fibroblast growth factor receptor signaling pathway (traceable author statement from ProtInc).
GO:0007399; Biological process: nervous system development (traceable author statement from ProtInc).
QuickGo view.
Family and domain databases
InterPro IPR002209; GF_heparin_bd.
IPR002348; IL1_HBGF.
Graphical view of domain structure.
PANTHER PTHR11486; IL1_HBGF; 1.
Pfam PF00167; FGF; 1.
Pfam graphical view of domain structure.
PRINTS PR00263; HBGFFGF.
PR00262; IL1HBGF.
ProDom PD000831; IL1_HBGF; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00442; FGF; 1.
SMART graphical view of domain structure.
PROSITE PS00247; HBGF_FGF; 1.
BLOCKS P12034.
Genome annotation databases
Ensembl ENSG00000138675; Homo sapiens. [Contig view]
GeneID 2250; -.
KEGG hsa:2250; -.
Phylogenomic databases
HOGENOM P12034; -.
HOVERGEN P12034; -.
Other
SOURCE FGF5; Homo sapiens.
ProtoNet P12034.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; Glycoprotein; Growth factor; Mitogen; Polymorphism; Proto-oncogene; Secreted; Signal.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
SIGNAL   1    17  17     Potential. 
CHAIN   18   268  251     Fibroblast growth factor 5. PRO_0000008958
COMPBIAS   49    52  4     Poly-Ser. 
COMPBIAS   55    62  8     Poly-Ser. 
CARBOHYD   110   110        N-linked (GlcNAc...) (Potential). 
VAR_SEQ   120   123        VLEI -> QVHR (in isoform Short). VSP_001518
VAR_SEQ   124   268        Missing (in isoform Short). VSP_001519
VARIANT   54    54  1     M -> V (in dbSNP:rs33950145 [NCBI]). VAR_025174 
CONFLICT   42    42        R -> I (in Ref. 1; AAB06463). 
CONFLICT   83    86        PSGR -> LGA (in Ref. 2; AAB60699). 
CONFLICT   224   224        Q -> QQ (in Ref. 5; AAZ67914). 
CONFLICT   238   238        K -> N (in Ref. 1 and 2). 
CONFLICT   245   245        P -> S (in Ref. 1 and 2). 
Sequence information
Length: 268 AA [This is the length of the unprocessed precursor] Molecular weight: 29551 Da [This is the MW of the unprocessed precursor] CRC64: 28B7268B26781BCF [This is a checksum on the sequence]
        10         20         30         40         50         60 
MSLSFLLLLF FSHLILSAWA HGEKRLAPKG QPGPAATDRN PRGSSSRQSS SSAMSSSSAS 

        70         80         90        100        110        120 
SSPAASLGSQ GSGLEQSSFQ WSPSGRRTGS LYCRVGIGFH LQIYPDGKVN GSHEANMLSV 

       130        140        150        160        170        180 
LEIFAVSQGI VGIRGVFSNK FLAMSKKGKL HASAKFTDDC KFRERFQENS YNTYASAIHR 

       190        200        210        220        230        240 
TEKTGREWYV ALNKRGKAKR GCSPRVKPQH ISTHFLPRFK QSEQPELSFT VTVPEKKKPP 

       250        260 
SPIKPKIPLS APRKNTNSVK YRLKFRFG 

P12034 in FASTA format

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