[1]	NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG). TISSUE=Brain stem; DOI=10.1073/pnas.87.20.8022; PubMed=1700424 [NCBI, ExPASy, EBI, Israel, Japan] Haub O., Drucker B., Goldfarb M.; "Expression of the murine fibroblast growth factor 5 gene in the adult central nervous system."; Proc. Natl. Acad. Sci. U.S.A. 87:8022-8026(1990).
[2]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. PubMed=3211147 [NCBI, ExPASy, EBI, Israel, Japan] Zhan X., Bates B., Hu X., Goldfarb M.; "The human FGF-5 oncogene encodes a novel protein related to fibroblast growth factors."; Mol. Cell. Biol. 8:3487-3495(1988).
[3]	NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT). Ozawa K., Suzuki S., Asada M., Tomooka Y., Li A., Yoneda A., Komi A., Imamura T.; "An alternatively-spliced FGF-5 mRNA is abundant in brain and translates into a partial agonist/antagonist for FGF-5 neurotrophic activity."; Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases.
[4]	NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT). TISSUE=Umbilical artery; DOI=10.1074/jbc.M910099199; PubMed=10823842 [NCBI, ExPASy, EBI, Israel, Japan] de Vries C.J.M., van Achterberg T.A.E., Horrevoets A.J.G., ten Cate J.W., Pannekoek H.; "Differential display identification of 40 genes with altered expression in activated human smooth muscle cells. Local expression in atherosclerotic lesions of smags, smooth muscle activation-specific genes."; J. Biol. Chem. 275:23939-23947(2000).
[5]	NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT VAL-54. NIEHS SNPs program; Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase (By similarity).
SUBCELLULAR LOCATION: Secreted (Potential).

ALTERNATIVE PRODUCTS: 2 named isoforms [FASTA] produced by alternative splicing.

Name	Long
Isoform ID	P12034-1
This is the isoform sequence displayed in this entry.

Name	Short
Synonyms	FGF-5S
Isoform ID	P12034-2
Note: Seems to have an antagonistic effect compared to that of the isoform Long.
Features which should be applied to build the isoform sequence: VSP_001518, VSP_001519.

TISSUE SPECIFICITY: Expressed in neonatal brain.
DEVELOPMENTAL STAGE: Can transform NIH 3T3 cells.
SIMILARITY: Belongs to the heparin-binding growth factors family.
WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/fgf5/";.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

M37825; AAB06463.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
M23536; AAB60699.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
M23534; AAB60699.1; JOINED; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
M23535; AAB60699.1; JOINED; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
M23534; AAB60698.1; ALT_SEQ; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AB016517; BAA33738.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AF171928; AAF89742.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
DQ151636; AAZ67914.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

IPI

IPI00295390; -.
IPI00743518; -.

PIR

A31194; TVHUF5.
B31194; B31194.

RefSeq

NP_004455.2; -.
NP_149134.1; -.

UniGene

Hs.37055

3D structure databases

HSSP

P08620; 1IJT. [HSSP ENTRY / PDB]

ModBase

P12034.

Protein-protein interaction databases

DIP

DIP:4018N; -.

Enzyme and pathway databases

Reactome

REACT_9470; Signaling by FGFR.

Organism-specific databases

GC04P081406; -.

HGNC:3683; FGF5.

CAB010313; -.

165190; gene. [NCBI / EBI]

PharmGKB

PA28122; -.

Gene expression databases

P12034; -.

P12034; -.

HS_FGF5; -.

ENSG00000138675; Homo sapiens.

Ontologies

GO:0005615;	Cellular component: extracellular space (traceable author statement from ProtInc).
GO:0008083;	Molecular function: growth factor activity (inferred from electronic annotation from UniProtKB-KW).
GO:0008283;	Biological process: cell proliferation (traceable author statement from ProtInc).
GO:0007267;	Biological process: cell-cell signaling (traceable author statement from ProtInc).
GO:0008543;	Biological process: fibroblast growth factor receptor signaling pathway (inferred from experiment from Reactome).
QuickGo view.

Family and domain databases

InterPro

IPR002209; GF_heparin_bd.
IPR002348; IL1_HBGF.
Graphical view of domain structure.

PANTHER

PTHR11486; IL1_HBGF; 1.

Pfam

PF00167; FGF; 1.
Pfam graphical view of domain structure.

PRINTS

PR00263; HBGFFGF.
PR00262; IL1HBGF.

ProDom

PD000831; IL1_HBGF; 1.
[Domain structure / List of seq. sharing at least 1 domain]

SMART

SM00442; FGF; 1.
SMART graphical view of domain structure.

PROSITE

PS00247; HBGF_FGF; 1.

Proteomic databases

PRIDE

P12034; -.

Genome annotation databases

Ensembl

ENSG00000138675; Homo sapiens. [Contig view]

GeneID

2250; -.

KEGG

hsa:2250; -.

Phylogenomic databases

HOGENOM

P12034; -.

HOVERGEN

P12034; -.

OMA

P12034; SHEANML.

Other

9107; -.

FGF5; Homo sapiens.

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Alternative splicing; Glycoprotein; Growth factor; Mitogen; Polymorphism; Proto-oncogene; Secreted; Signal.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 17`	`17`	`Potential.`
`CHAIN`	`18 268`	`251`	`Fibroblast growth factor 5.`	`PRO_0000008958`
`COMPBIAS`	`49 52`	`4`	`Poly-Ser.`
`COMPBIAS`	`55 62`	`8`	`Poly-Ser.`
`CARBOHYD`	`110 110`		`N-linked (GlcNAc...) (Potential).`
`VAR_SEQ`	`120 123`		`VLEI -> QVHR (in isoform Short).`	`VSP_001518`
`VAR_SEQ`	`124 268`		`Missing (in isoform Short).`	`VSP_001519`
`VARIANT`	`54 54`	`1`	`M -> V (in dbSNP:rs33950145 [NCBI]).`	`VAR_025174`
`CONFLICT`	`42 42`		`R -> I (in Ref. 1; AAB06463).`
`CONFLICT`	`83 86`		`PSGR -> LGA (in Ref. 2; AAB60699).`
`CONFLICT`	`224 224`		`Q -> QQ (in Ref. 5; AAZ67914).`
`CONFLICT`	`238 238`		`K -> N (in Ref. 1 and 2).`
`CONFLICT`	`245 245`		`P -> S (in Ref. 1 and 2).`

Sequence information

Length: 268 AA [This is the length of the unprocessed precursor]

Molecular weight: 29551 Da [This is the MW of the unprocessed precursor]

CRC64: 28B7268B26781BCF [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSLSFLLLLF FSHLILSAWA HGEKRLAPKG QPGPAATDRN PRGSSSRQSS SSAMSSSSAS 

        70         80         90        100        110        120 
SSPAASLGSQ GSGLEQSSFQ WSPSGRRTGS LYCRVGIGFH LQIYPDGKVN GSHEANMLSV 

       130        140        150        160        170        180 
LEIFAVSQGI VGIRGVFSNK FLAMSKKGKL HASAKFTDDC KFRERFQENS YNTYASAIHR 

       190        200        210        220        230        240 
TEKTGREWYV ALNKRGKAKR GCSPRVKPQH ISTHFLPRFK QSEQPELSFT VTVPEKKKPP 

       250        260 
SPIKPKIPLS APRKNTNSVK YRLKFRFG

P12034 in FASTA format

View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools