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UniProtKB/Swiss-Prot entry P08499


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DHOM_CORGL
Primary accession number P08499
Secondary accession numbers None
Integrated into Swiss-Prot on August 1, 1988
Sequence was last modified on August 1, 1988 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 67)
Name and origin of the protein
Protein name Homoserine dehydrogenase
Synonyms HDH
EC 1.1.1.3
Gene name
Name: hom
Synonyms: thrA
OrderedLocusNames: Cgl1183, cg1337
From
Corynebacterium glutamicum (Brevibacterium flavum) [TaxID: 1718] [HAMAP proteome]
Taxonomy Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Corynebacterineae; Corynebacteriaceae; Corynebacterium.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 13059 / LMG 3658 / NCIB 10332 / AS019 / 613;
PubMed=2835591 [NCBI, ExPASy, EBI, Israel, Japan]
Peoples O.P., Liebl W., Bodis M., Maeng P.J., Follettie M.T., Archer J.A.C., Sinskey A.J.;
"Nucleotide sequence and fine structural analysis of the Corynebacterium glutamicum hom-thrB operon.";
Mol. Microbiol. 2:63-72(1988).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1093/nar/15.24.10598; PubMed=3320973 [NCBI, ExPASy, EBI, Israel, Japan]
Mateos L.M., del Real G., Aguilar A., Martin J.F.;
"Nucleotide sequence of the homoserine dehydrogenase (thr A) gene of Brevibacterium lactofermentum.";
Nucleic Acids Res. 15:10598-10598(1987).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=9362124 [NCBI, ExPASy, EBI, Israel, Japan]
Sugimoto M., Tanaka A., Suzuki T., Matsui H., Nakamori S., Takagi H.;
"Sequence analysis of functional regions of homoserine dehydrogenase genes from L-lysine and L-threonine-producing mutants of Brevibacterium lactofermentum.";
Biosci. Biotechnol. Biochem. 61:1760-1762(1997).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025;
Nakagawa S.;
"Complete genomic sequence of Corynebacterium glutamicum ATCC 13032.";
Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025;
DOI=10.1016/S0168-1656(03)00154-8; PubMed=12948626 [NCBI, ExPASy, EBI, Israel, Japan]
Kalinowski J., Bathe B., Bartels D., Bischoff N., Bott M., Burkovski A., Dusch N., Eggeling L., Eikmanns B.J., Gaigalat L., Goesmann A., Hartmann M., Huthmacher K., Kraemer R., Linke B., McHardy A.C., Meyer F., Moeckel B., Pfefferle W., Puehler A., Rey D.A., Rueckert C., Rupp O., Sahm H., Wendisch V.F., Wiegraebe I., Tauch A.;
"The complete Corynebacterium glutamicum ATCC 13032 genome sequence and its impact on the production of L-aspartate-derived amino acids and vitamins.";
J. Biotechnol. 104:5-25(2003).
[6]
MUTANT RESISTANT TO FEEDBACK INHIBITION (FBR).
PubMed=1902466 [NCBI, ExPASy, EBI, Israel, Japan]
Reinscheid D.J., Eikmanns B.J., Sahm H.;
"Analysis of a Corynebacterium glutamicum hom gene coding for a feedback-resistant homoserine dehydrogenase.";
J. Bacteriol. 173:3228-3230(1991).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
Y00546; CAA68614.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
Y00476; CAA68536.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BA000036; BAB98576.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BX927151; CAF19887.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S00865; DEFKHG.
RefSeq NP_600409.1; -.
YP_225473.1; -.
3D structure databases
ModBase P08499.
Enzyme and pathway databases
BioCyc CGLU196627-1:CG1337-MON; -.
2D gel databases
World-2DPAGE 0001:P08499; -.
Family and domain databases
InterPro IPR002912; ACT_bd.
IPR005106; Asp/hSer_DHase_NAD-bd.
IPR016204; hSer_DHase.
IPR001342; hSer_DHase_cat.
Graphical view of domain structure.
Pfam PF01842; ACT; 1.
PF00742; Homoserine_dh; 1.
PF03447; NAD_binding_3; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000098; Homoser_dehydrog; 1.
PROSITE PS01042; HOMOSER_DHGENASE; 1.
BLOCKS P08499.
Genome annotation databases
GeneID 1019166; -.
3343957; -.
GenomeReviews BX927147_GR; cg1337.
BA000036_GR; Cgl1183.
KEGG cgb:cg1337; -.
cgl:NCgl1136; -.
Phylogenomic databases
HOGENOM P08499; -.
Genome annotation databases
CMR P08499; Cgl1183.
Other
ProtoNet P08499.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Branched-chain amino acid biosynthesis; Complete proteome; Isoleucine biosynthesis; Methionine biosynthesis; NADP; Oxidoreductase; Threonine biosynthesis.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   445  445     Homoserine dehydrogenase. PRO_0000066693
DOMAIN   367   439  73     ACT. 
NP_BIND   24    31  8     NADP (By similarity). 
ACT_SITE   219   219        Proton donor (Potential). 
BINDING   119   119        NADP (By similarity). 
BINDING   204   204        Substrate (By similarity). 
VARIANT   378   378  1     G -> E (in FBR mutant). 
Sequence information
Length: 445 AA [This is the length of the unprocessed precursor] Molecular weight: 46438 Da [This is the MW of the unprocessed precursor] CRC64: 02731E502303CB1C [This is a checksum on the sequence]
        10         20         30         40         50         60 
MTSASAPSFN PGKGPGSAVG IALLGFGTVG TEVMRLMTEY GDELAHRIGG PLEVRGIAVS 

        70         80         90        100        110        120 
DISKPREGVA PELLTEDAFA LIEREDVDIV VEVIGGIEYP REVVLAALKA GKSVVTANKA 

       130        140        150        160        170        180 
LVAAHSAELA DAAEAANVDL YFEAAVAGAI PVVGPLRRSL AGDQIQSVMG IVNGTTNFIL 

       190        200        210        220        230        240 
DAMDSTGADY ADSLAEATRL GYAEADPTAD VEGHDAASKA AILASIAFHT RVTADDVYCE 

       250        260        270        280        290        300 
GISNISAADI EAAQQAGHTI KLLAICEKFT NKEGKSAISA RVHPTLLPVS HPLASVNKSF 

       310        320        330        340        350        360 
NAIFVEAEAA GRLMFYGNGA GGAPTASAVL GDVVGAARNK VHGGRAPGES TYANLPIADF 

       370        380        390        400        410        420 
GETTTRYHLD MDVEDRVGVL AELASLFSEQ GISLRTIRQE ERDDDARLIV VTHSALESDL 

       430        440 
SRTVELLKAK PVVKAINSVI RLERD 

P08499 in FASTA format

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