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UniProtKB/Swiss-Prot entry P04041

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name GPX1_RAT
Primary accession number P04041
Secondary accession numbers O08946 Q4PIY2 Q91WZ5
Integrated into Swiss-Prot on November 1, 1986
Sequence was last modified on February 26, 2008 (Sequence version 4)
Annotations were last modified on    November 25, 2008 (Entry version 83)
Name and origin of the protein
Protein name Glutathione peroxidase 1
Synonyms EC 1.11.1.9
GSHPx-1
GPx-1
Cellular glutathione peroxidase
Gene name
Name: Gpx1
From
Rattus norvegicus (Rat) [TaxID: 10116] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1016/0006-291X(88)90242-2; PubMed=3408482 [NCBI, ExPASy, EBI, Israel, Japan]
Yoshimura S., Takekoshi S., Watanabe K., Fujii-Kuriyama Y.;
"Determination of nucleotide sequence of cDNA coding rat glutathione peroxidase and diminished expression of the mRNA in selenium deficient rat liver.";
Biochem. Biophys. Res. Commun. 154:1024-1028(1988).
[2]
 NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Sprague-Dawley;
TISSUE=Liver;
DOI=10.1093/nar/16.11.5207; PubMed=3387231 [NCBI, ExPASy, EBI, Israel, Japan]
Ho Y.S., Howard A.J., Crapo J.D.;
"Nucleotide sequence of a rat glutathione peroxidase cDNA.";
Nucleic Acids Res. 16:5207-5207(1988).
[3]
 NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1093/nar/16.12.5557; PubMed=2838821 [NCBI, ExPASy, EBI, Israel, Japan]
Reddy A.P., Hsu B.L., Reddy P.S., Li N.Q., Thyagaraju K., Reddy C.C., Tam M.F., Tu C.P.D.;
"Expression of glutathione peroxidase I gene in selenium-deficient rats.";
Nucleic Acids Res. 16:5557-5568(1988).
[4]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND TISSUE SPECIFICITY.
STRAIN=Sprague-Dawley;
DOI=10.1016/0014-5793(92)80198-P; PubMed=1451786 [NCBI, ExPASy, EBI, Israel, Japan]
Ho Y.-S., Howard A.J.;
"Cloning and characterization of the rat glutathione peroxidase gene.";
FEBS Lett. 301:5-9(1992).
[5]
 NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Sprague-Dawley;
TISSUE=Liver;
PubMed=1640255 [NCBI, ExPASy, EBI, Israel, Japan]
Christensen M.J., Burgener K.W.;
"Dietary selenium stabilizes glutathione peroxidase mRNA in rat liver.";
J. Nutr. 122:1620-1626(1992).
[6]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-82.
STRAIN=Sprague-Dawley;
Suemizu H.;
"Functional analysis of the 5'-flanking region of the rat glutathione peroxidase gene.";
Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases.
[7]
 PROTEIN SEQUENCE OF 7-52, AND SELENOCYSTEINE AT SEC-47.
TISSUE=Liver;
DOI=10.1016/0167-4838(82)90472-1; PubMed=6217842 [NCBI, ExPASy, EBI, Israel, Japan]
Condell R.A., Tappel A.L.;
"Amino acid sequence around the active-site selenocysteine of rat liver glutathione peroxidase.";
Biochim. Biophys. Acta 709:304-309(1982).
[8]
 PROTEIN SEQUENCE OF 96-112 AND 165-176, AND MASS SPECTROMETRY.
STRAIN=Sprague-Dawley;
TISSUE=Spinal cord;
Lubec G., Afjehi-Sadat L.;
Submitted (NOV-2006) to UniProtKB.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M21210; AAB95647.2; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X07365; CAB43593.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X12367; CAA30928.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
S50336; AAA12407.2; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
S41066; AAK72702.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB004231; BAA20399.2; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A30793; OPRTE.
RefSeq NP_110453.3; -.
UniGene Rn.11323
3D structure databases
HSSP P00435; 1GP1. [HSSP ENTRY / PDB]
SMR P04041; 13-195.
ModBase P04041.
Protein family/group databases
PeroxiBase 3730; RnoGPx01.
Organism-specific databases
RGD 2729; Gpx1.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from UniProtKB-KW).
GO:0004602; Molecular function: glutathione peroxidase activity (inferred from electronic annotation from InterPro).
GO:0008430; Molecular function: selenium binding (inferred from electronic annotation from UniProtKB-KW).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0006979; Biological process: response to oxidative stress (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR000889; Glut_peroxidase.
IPR012335; Thioredoxin_fold.
Graphical view of domain structure.
Gene3D G3DSA:3.40.30.10; Thioredoxin_fold; 1.
PANTHER PTHR11592; Glut_peroxidase; 1.
Pfam PF00255; GSHPx; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000303; Glutathion_perox; 1.
PRINTS PR01011; GLUTPROXDASE.
PROSITE PS00460; GLUTATHIONE_PEROXID_1; 1.
PS00763; GLUTATHIONE_PEROXID_2; 1.
PS51355; GLUTATHIONE_PEROXID_3; 1.
PROSITE graphical view of domain structure (profiles).
ProtoNet P04041.
Genome annotation databases
GeneID 24404; -.
KEGG rno:24404; -.
Phylogenomic databases
HOVERGEN P04041; -.
Other
NextBio 603207; -.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Acetylation; Cytoplasm; Direct protein sequencing; Oxidoreductase; Peroxidase; Selenium; Selenocysteine.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   201  201     Glutathione peroxidase 1. PRO_0000066617
ACT_SITE   47    47         
NON_STD   47    47        Selenocysteine. 
MOD_RES   146   146        N6-acetyllysine (By similarity). 
CONFLICT   24    25        GG -> RE (in Ref. 1; AAB95647). 
CONFLICT   154   154        C -> S (in Ref. 1; AAB95647). 
CONFLICT   178   178        S -> T (in Ref. 1; AAB95647). 
CONFLICT   198   198        P -> S (in Ref. 1; AAB95647). 
Sequence information
Length: 201 AA [This is the length of the unprocessed precursor] Molecular weight: 22305 Da [This is the MW of the unprocessed precursor] CRC64: 093528A214615A11 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSAARLSAVA QSTVYAFSAR PLAGGEPVSL GSLRGKVLLI ENVASLUGTT TRDYTEMNDL 

        70         80         90        100        110        120 
QKRLGPRGLV VLGFPCNQFG HQENGKNEEI LNSLKYVRPG GGFEPNFTLF EKCEVNGEKA 

       130        140        150        160        170        180 
HPLFTFLRNA LPAPSDDPTA LMTDPKYIIW SPVCRNDISW NFEKFLVGPD GVPVRRYSRR 

       190        200 
FRTIDIEPDI EALLSKQPSN P
P04041 in FASTA format

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