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UniProtKB/Swiss-Prot entry P03594

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ORF2A_BMV
Primary accession number P03594
Secondary accession numbers None
Integrated into Swiss-Prot on July 21, 1986
Sequence was last modified on July 21, 1986 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 48)
Name and origin of the protein
Protein name RNA-directed RNA polymerase 2A
Synonyms protein 2A
EC 2.7.7.48
Gene name
Name: RNA2
ORFNames: ORF2a
From
Brome mosaic virus (BMV) [TaxID: 12302] 
Taxonomy Viruses; ssRNA positive-strand viruses, no DNA stage; Bromoviridae; Bromovirus.
Virus host Bromus inermis (Smooth brome grass) [TaxID: 15371]
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE.
DOI=10.1016/S0022-2836(84)80012-1; PubMed=6694215 [NCBI, ExPASy, EBI, Israel, Japan]
Ahlquist P., Dasgupta R., Kaesberg P.;
"Nucleotide sequence of the brome mosaic virus genome and its implications for viral replication.";
J. Mol. Biol. 172:369-383(1984).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X01678; CAA25834.1; -; Unassigned_RNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A04202; P2BVA.
RefSeq NP_041197.1; -.
3D structure databases
ModBase P03594.
Ontologies
GO
GO:0000166; Molecular function: nucleotide binding (inferred from electronic annotation from UniProtKB-KW).
GO:0003723; Molecular function: RNA binding (inferred from electronic annotation from InterPro).
GO:0003968; Molecular function: RNA-directed RNA polymerase activity (inferred from electronic annotation from InterPro).
GO:0006410; Biological process: transcription, RNA-dependent (inferred from electronic annotation from UniProtKB-KW).
GO:0019079; Biological process: viral genome replication (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR007610; DUF585.
IPR001788; RNA-dep_RNA_pol_vir-typ.
IPR007094; RNA_pol_PSvir.
Graphical view of domain structure.
Pfam PF04522; DUF585; 1.
PF00978; RdRP_2; 1.
Pfam graphical view of domain structure.
PROSITE PS50507; RDRP_SSRNA_POS; 1.
PROSITE graphical view of domain structure (profiles).
ProtoNet P03594.
Genome annotation databases
GeneID 962145; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Nucleotide-binding; Nucleotidyltransferase; RNA replication; RNA-directed RNA polymerase; Transferase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   822  822     RNA-directed RNA polymerase 2A. PRO_0000083269
DOMAIN   459   572  114     RdRp catalytic. 
Sequence information
Length: 822 AA [This is the length of the unprocessed precursor] Molecular weight: 93927 Da [This is the MW of the unprocessed precursor] CRC64: C13B99016B2C54AC [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSSKTWDDDF VRQVPSFQWI IDQSLEDEVE AASLQVQEPA DGVAIDGSLA SFKLAIAPLE 

        70         80         90        100        110        120 
IGGVFDPPFD RVRWGSICDT VQQMVQQFTD RPLIPQAEMA RMLYLDIPGS FVLEDEIDDW 

       130        140        150        160        170        180 
YPEDTSDGYG VSFAADEDHA SDLKLASDSS NCEIEEVRVT GDTPKELTLG DRYMGIDEEF 

       190        200        210        220        230        240 
QTTNTDYDIT LQIMNPIEHR VSRVIDTHCH PDNPDISTGP IYMERVSLAR TEATSHSILP 

       250        260        270        280        290        300 
THAYFDDSYH QALVENGDYS MDFDRIRLKQ SDVDWYRDPD KYFQPKMNIG SAQRRVGTQK 

       310        320        330        340        350        360 
EVLTALKKRN ADVPEMGDAI NMKDTAKAIA KRFRSTFLNV DGEDCLRASM DVMTKCLEYH 

       370        380        390        400        410        420 
KKWGKHMDLQ GVNVAAETDL CRYQHMLKSD VKPVVTDTLH LERAVAATIT FHSKGVTSNF 

       430        440        450        460        470        480 
SPFFTACFEK LSLALKSRFI VPIGKISSLE LKNVRLNNRY FLEADLSKFD KSQGELHLEF 

       490        500        510        520        530        540 
QREILLALGF PAPLTNWWSD FHRDSYLSDP HAKVGMSVSF QRRTGDAFTY FGNTLVTMAM 

       550        560        570        580        590        600 
IAYASDLSDC DCAIFSGDDS LIISKVKPVL DTDMFTSLFN MEIKVMDPSV PYVCSKFLVE 

       610        620        630        640        650        660 
TEMGNLVSVP DPLREIQRLA KRKILRDEQM LRAHFVSFCD RMKFINQLDE KMITTLCHFV 

       670        680        690        700        710        720 
YLKYGKEKPW IFEEVRAALA AFSLYSENFL RFSDCYCTEG IRVYQMSDPV CKFKRTTEER 

       730        740        750        760        770        780 
KTDGDWFHNW KNPKFPGVLD KVYRTIGIYS SDCSTKELPV KRIGRLHEAL ERESLKLAND 

       790        800        810        820 
RRTTQRLKKK VDDYATGRGG LTSVDALLVK SHCETFKPSD LR
P03594 in FASTA format

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