Apium graveolens (Celery) [TaxID: 4045]
Astragalus glycyphyllos (Wild liquorice) [TaxID: 83862]
Capsicum annuum (Bell pepper) [TaxID: 4072]
Caryopteris incana [TaxID: 41386]
Cicer arietinum (Chickpea) (Garbanzo) [TaxID: 3827]
Dolichos lab lab (Field bean) (Lablab purpureus) [TaxID: 35936]
Glycine max (Soybean) [TaxID: 3847]
Lactuca sativa (Garden lettuce) [TaxID: 4236]
Lens culinaris (Lentil) (Cicer lens) [TaxID: 3864]
Lupinus [TaxID: 3869]
Malva parviflora (Little mallow) (Cheeseweed mallow) [TaxID: 145753]
Medicago sativa (Alfalfa) [TaxID: 3879]
Nicotiana tabacum (Common tobacco) [TaxID: 4097]
Phaseolus aureus (Mung bean) (Vigna radiata) [TaxID: 3916]
Phaseolus vulgaris (Kidney bean) (French bean) [TaxID: 3885]
Philadelphus [TaxID: 23113]
Pisum sativum (Garden pea) [TaxID: 3888]
Solanum lycopersicum (Tomato) (Lycopersicon esculentum) [TaxID: 4081]
Solanum tuberosum (Potato) [TaxID: 4113]
Teramnus repens [TaxID: 157662]
Trifolium incarnatum (Crimson clover) [TaxID: 60916]
Viburnum opulus (Guelder-rose) [TaxID: 85293]
Vigna unguiculata (Cowpea) [TaxID: 3917]

Protein existence

4: Predicted;

References

[1]	NUCLEOTIDE SEQUENCE. DOI=10.1093/nar/11.10.3019; PubMed=6304618 [NCBI, ExPASy, EBI, Israel, Japan] Cornelissen B.J.C., Brederode F.T., Veeneman G.H., van Boom J.H., Bol J.F.; "Complete nucleotide sequence of alfalfa mosaic virus RNA 2."; Nucleic Acids Res. 11:3019-3025(1983).

Comments

FUNCTION: RNA-directed RNA polymerase.
CATALYTIC ACTIVITY: Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
MISCELLANEOUS: The virus has a tripartite genome (RNA1, RNA2 and RNA3) and an encapsidated subgenomic RNA (RNA4) from which the coat protein is expressed.
SIMILARITY: Contains 1 RdRp catalytic domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

X01572; CAA25728.1; -; Unassigned_RNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

A04201; WMFM9.

RefSeq

YP_053235.1; -.

3D structure databases

ModBase

P03593.

Ontologies

GO:0000166;	Molecular function: nucleotide binding (inferred from electronic annotation from UniProtKB-KW).
GO:0003723;	Molecular function: RNA binding (inferred from electronic annotation from InterPro).
GO:0003968;	Molecular function: RNA-directed RNA polymerase activity (inferred from electronic annotation from InterPro).
GO:0006410;	Biological process: transcription, RNA-dependent (inferred from electronic annotation from UniProtKB-KW).
GO:0019079;	Biological process: viral genome replication (inferred from electronic annotation from InterPro).
QuickGo view.

Family and domain databases

InterPro

IPR001788; RNA-dep_RNA_pol_vir-typ.
IPR007094; RNA_pol_PSvir.
Graphical view of domain structure.

Pfam

PF00978; RdRP_2; 1.
Pfam graphical view of domain structure.

PROSITE

PS50507; RDRP_SSRNA_POS; 1.
PROSITE graphical view of domain structure (profiles).

ProtoNet

P03593.

Genome annotation databases

GeneID

962668; -.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Nucleotide-binding; Nucleotidyltransferase; RNA replication; RNA-directed RNA polymerase; Transferase.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 790`	`790`	`RNA-directed RNA polymerase 2A.`	`PRO_0000083267`
`DOMAIN`	`524 639`	`116`	`RdRp catalytic.`

Sequence information

Length: 790 AA [This is the length of the unprocessed precursor]

Molecular weight: 89855 Da [This is the MW of the unprocessed precursor]

CRC64: B435C9EB9AA853C2 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MFTLLRCLGF GVNEPTNTSS SEYVPEYSVE EISNEVAELD SVDPLFQCYK HVFVSLMLVR 

        70         80         90        100        110        120 
KMTQAAEDFL ESFGGEFDSP CCRVYRLYRH FVNEDDAPAW AIPNVVNEDS YDDYAYLREE 

       130        140        150        160        170        180 
LDAIDSSFEL LNEERELSEI TDRLNALRFF PVSKTEALPV ANVQEVKLIS ETYQLLMTFI 

       190        200        210        220        230        240 
NYSDENIPSE MPAPLLDELG MLPEELGPLN EIEDIKPVAA PITLLSEFRA SDNAKPLDIV 

       250        260        270        280        290        300 
EIIPDVSPTK PYEAVISGND WMTLGRIIPT TPVPTIRDVF FSGLSRHGSP EVIQNALDEF 

       310        320        330        340        350        360 
LPLHHSIDDK YFQEWVETSD KSLDVDPCRI DLSVFNNWQS SENCYEPRFK TGALSTRKGT 

       370        380        390        400        410        420 
QTEALLAIKK RNMNVPNLGQ IYDVNSVANS VVNKLLTTVI DPDKLCMFPD FISEGEVSYF 

       430        440        450        460        470        480 
QDYIVGKNPD PELYSDPLGV RSIDSYKHMI KSVLKPVEDN SLHLERPMPA TITYHDKDIV 

       490        500        510        520        530        540 
MSSSPIFLAA AARLMLILRD KITIPSGKFH QLFSIDAEAF DASFHFKEID FSKFDKSQNE 

       550        560        570        580        590        600 
LHHLIQERFL KYLGIPNEFL TLWFNAHRKS RISDSKNGVF FNVDFQRRTG DALTYLGNTI 

       610        620        630        640        650        660 
VTLACLCHVY DLMDPNVKFV VASGDDSLIG TVEELPRDQE FLFTTLFNLE AKFPHNQPFI 

       670        680        690        700        710        720 
CSKFLITMPT TSGGKVVLPI PNPLKLLIRL GSKKVNADIF DEWYQSWIDI IGGFNDHHVI 

       730        740        750        760        770        780 
RCVAAMTAHR YLRRPSLYLE AALESLGKIF AGKTLCKECL FNEKHESNVK IKPRRVKKSH 

       790 
SDARSRARRA

P03593 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools