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UniProtKB/Swiss-Prot entry P01101


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name FOS_MOUSE
Primary accession number P01101
Secondary accession numbers None
Integrated into Swiss-Prot on July 21, 1986
Sequence was last modified on July 21, 1986 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 75)
Name and origin of the protein
Protein name Proto-oncogene protein c-fos
Synonym Cellular oncogene fos
Gene name
Name: Fos
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1016/0092-8674(83)90306-9; PubMed=6301687 [NCBI, ExPASy, EBI, Israel, Japan]
van Beveren C., van Straaten F., Curran T., Mueller R., Verma I.M.;
"Analysis of FBJ-MuSV provirus and c-fos (mouse) gene reveals that viral and cellular fos gene products have different carboxy termini.";
Cell 32:1241-1255(1983).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=2991903 [NCBI, ExPASy, EBI, Israel, Japan]
Meijlink F., Curran T., Miller A.D., Verma I.M.;
"Removal of a 67-base-pair sequence in the noncoding region of protooncogene fos converts it to a transforming gene.";
Proc. Natl. Acad. Sci. U.S.A. 82:4987-4991(1985).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=FVB/N;
TISSUE=Mammary gland;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
INTERACTION WITH DSIPI.
DOI=10.1074/jbc.M101522200; PubMed=11397794 [NCBI, ExPASy, EBI, Israel, Japan]
Mittelstadt P.R., Ashwell J.D.;
"Inhibition of AP-1 by the glucocorticoid-inducible protein GILZ.";
J. Biol. Chem. 276:29603-29610(2001).
Comments
  • FUNCTION: Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation.
  • SUBUNIT: Heterodimer. Interacts with DSIPI; this interaction inhibits the binding of active AP1 to its target DNA. Interacts with MAFB (By similarity).
  • SUBCELLULAR LOCATION: Nucleus.
  • INDUCTION: C-fos expression increases upon a variety of stimuli, including growth factors, cytokines, neurotransmitters, polypeptide hormones, stress and cell injury.
  • SIMILARITY: Belongs to the bZIP family. Fos subfamily.
  • SIMILARITY: Contains 1 bZIP domain.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
V00727; CAA24105.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
J00370; AAA96699.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC029814; AAH29814.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A01343; TVMSF.
RefSeq NP_034364.1; -.
UniGene Mm.246513
3D structure databases
HSSP P01100; 1FOS. [HSSP ENTRY / PDB]
SMR P01101; 139-198.
ModBase P01101.
Protein-protein interaction databases
DIP DIP:1066N; -.
PTM databases
PhosphoSite P01101; -.
Organism-specific databases
MGI MGI:95574; Fos.
Gene expression databases
ArrayExpress P01101; -.
CleanEx MM_FOS; -.
GermOnline ENSMUSG00000021250; Mus musculus.
Ontologies
GO
GO:0005667; Cellular component: transcription factor complex (inferred from direct assay from MGI).
GO:0043565; Molecular function: sequence-specific DNA binding (inferred from electronic annotation from InterPro).
GO:0003700; Molecular function: transcription factor activity (inferred from direct assay from MGI).
GO:0031668; Biological process: cellular response to extracellular stimulus (inferred from mutant phenotype from MGI).
GO:0007399; Biological process: nervous system development (inferred from mutant phenotype from MGI).
GO:0045944; Biological process: positive regulation of transcription from RNA polymerase II promoter (inferred from mutant phenotype from MGI).
GO:0042493; Biological process: response to drug (inferred from direct assay from MGI).
QuickGo view.
Family and domain databases
InterPro IPR011700; bZIP_2.
IPR000837; Leuzip_Fos.
IPR004827; TF_bZIP.
Graphical view of domain structure.
Pfam PF07716; bZIP_2; 1.
Pfam graphical view of domain structure.
PRINTS PR00042; LEUZIPPRFOS.
SMART SM00338; BRLZ; 1.
SMART graphical view of domain structure.
PROSITE PS50217; BZIP; 1.
PS00036; BZIP_BASIC; 1.
PROSITE graphical view of domain structure (profiles).
ProtoNet P01101.
Genome annotation databases
Ensembl ENSMUSG00000021250; Mus musculus. [Contig view]
GeneID 14281; -.
KEGG mmu:14281; -.
Phylogenomic databases
HOGENOM P01101; -.
HOVERGEN P01101; -.
Other
NextBio 285657; -.
SOURCE Fos; Mus musculus.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
DNA-binding; Nucleus; Phosphoprotein; Proto-oncogene; Ubl conjugation.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   380  380     Proto-oncogene protein c-fos. PRO_0000076467
DOMAIN   165   193  29     Leucine-zipper. 
DNA_BIND   139   160  22     Basic motif. 
CROSSLNK   113   113        Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) (By similarity). 
Sequence information
Length: 380 AA [This is the length of the unprocessed precursor] Molecular weight: 40838 Da [This is the MW of the unprocessed precursor] CRC64: 475966265952B624 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MMFSGFNADY EASSSRCSSA SPAGDSLSYY HSPADSFSSM GSPVNTQDFC ADLSVSSANF 

        70         80         90        100        110        120 
IPTVTAISTS PDLQWLVQPT LVSSVAPSQT RAPHPYGLPT QSAGAYARAG MVKTVSGGRA 

       130        140        150        160        170        180 
QSIGRRGKVE QLSPEEEEKR RIRRERNKMA AAKCRNRRRE LTDTLQAETD QLEDEKSALQ 

       190        200        210        220        230        240 
TEIANLLKEK EKLEFILAAH RPACKIPDDL GFPEEMSVAS LDLTGGLPEA STPESEEAFT 

       250        260        270        280        290        300 
LPLLNDPEPK PSLEPVKSIS NVELKAEPFD DFLFPASSRP SGSETSRSVP DVDLSGSFYA 

       310        320        330        340        350        360 
ADWEPLHSNS LGMGPMVTEL EPLCTPVVTC TPGCTTYTSS FVFTYPEADS FPSCAAAHRK 

       370        380 
GSSSNEPSSD SLSSPTLLAL 

P01101 in FASTA format

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BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA)
Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
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