[1]	NUCLEOTIDE SEQUENCE [GENOMIC RNA]. STRAIN=H; DOI=10.1016/0092-8674(83)90209-X; PubMed=6313229 [NCBI, ExPASy, EBI, Israel, Japan] Yamamoto T., Nishida T., Miyajima N., Kawai S., Ooi T., Toyoshima K.; "The erbB gene of avian erythroblastosis virus is a member of the src gene family."; Cell 35:71-78(1983).
[2]	NUCLEOTIDE SEQUENCE [GENOMIC RNA] OF 1-152. PubMed=6328658 [NCBI, ExPASy, EBI, Israel, Japan] Debuire B., Henry C., Benaissa M., Biserte G., Claverie J.-M., Saule S., Martin P., Stehelin D.; "Sequencing the erbA gene of avian erythroblastosis virus reveals a new type of oncogene."; Science 224:1456-1459(1984).

Comments

FUNCTION: The v-erbB oncogene transforms avian fibroblasts and erythroblasts in culture and induces sarcomas and erythroleukemias in chickens. It is a truncated and mutated version of the receptor for epidermal growth factor.
CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
SIMILARITY: Contains 1 protein kinase domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

K02006; AAA42394.1; ALT_INIT; Genomic_RNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
K01216; AAA42400.1; -; Genomic_RNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

A00644; TVYUH.

3D structure databases

HSSP

Q9H2C9; 1M17. [HSSP ENTRY / PDB]

SMR

P00535; 116-426.

ModBase

P00535.

Ontologies

GO:0005524;	Molecular function: ATP binding (inferred from electronic annotation from InterPro).
GO:0004714;	Molecular function: transmembrane receptor protein tyrosine kinase activity (inferred from electronic annotation from EC).
GO:0006468;	Biological process: protein amino acid phosphorylation (inferred from electronic annotation from InterPro).
QuickGo view.

Family and domain databases

InterPro

IPR000719; Prot_kinase_core.
IPR017441; Protein_kinase_ATP_bd_CS.
IPR001245; Tyr_pkinase.
IPR008266; Tyr_pkinase_AS.
Graphical view of domain structure.

Pfam

PF07714; Pkinase_Tyr; 1.
Pfam graphical view of domain structure.

PRINTS

PR00109; TYRKINASE.

ProDom

PD000001; Prot_kinase; 1.
[Domain structure / List of seq. sharing at least 1 domain]

SMART

SM00219; TyrKc; 1.
SMART graphical view of domain structure.

PROSITE

PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PROSITE graphical view of domain structure (profiles).

ProtoNet

P00535.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

ATP-binding; Kinase; Nucleotide-binding; Oncogene; Phosphoprotein; Transferase; Tyrosine-protein kinase.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 604`	`604`	`Tyrosine-protein kinase transforming protein erbB.`	`PRO_0000160252`
`DOMAIN`	`132 399`	`268`	`Protein kinase.`
`NP_BIND`	`138 146`	`9`	`ATP (By similarity).`
`ACT_SITE`	`257 257`		`Proton acceptor (By similarity).`
`BINDING`	`165 165`		`ATP (By similarity).`
`CONFLICT`	`29 29`		`R -> W (in Ref. 2; AAA42394).`
`CONFLICT`	`140 140`		`S -> F (in Ref. 2; AAA42394).`
`CONFLICT`	`146 146`		`I -> V (in Ref. 2; AAA42394).`

Sequence information

Length: 604 AA [This is the length of the unprocessed precursor]

Molecular weight: 67633 Da [This is the MW of the unprocessed precursor]

CRC64: 76EBCDD06745D609 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MKCAHFIDGP HCVKACPAGV LGENDTLVRK YADANAVCQL CHPNCTRGCK GPGLEGCPNG 

        70         80         90        100        110        120 
SKTPSIAAGV VGGLLCLVVV GLGIGLYLRR RHIVRKRTLR RLLQERELVE PLTPSGEAPN 

       130        140        150        160        170        180 
QAHLRILKET EFKKVKVLGS GAFGTIYKGL WIPEGEKVKI PVAIKELREA TSPKANKEIL 

       190        200        210        220        230        240 
DEAYVMASVD NPHVCRLLGI CLTSTVQLIT QLMPYGCLLD YIREHKDNIG SQYLLNWCVQ 

       250        260        270        280        290        300 
IAKGMNYLEE RRLVHRDLAA RNVLVKTPQH VKITDFGLAK LLGADEKEYH AEGGKVPIKW 

       310        320        330        340        350        360 
MALESILHRI YTHQSDVWSY GVTVWELMTF GSKPYDGIPA SEISSVLEKG ERLPQPPICT 

       370        380        390        400        410        420 
IDVYMIMVKC WMIDADSRPK FRELIAEFSK MARDPPRYLV IQGDERMHLP SPTDSKFYRT 

       430        440        450        460        470        480 
LMEEEDMEDI VDADEYLVPH QGFFNSPSTS RTPLLSSLSA TSNNSATNCI DRNGQGHPVR 

       490        500        510        520        530        540 
EDSFVQRYSS DPTGNFLEES IDDGFLPAPE YVNQLMPKKP STAMVQNQIY NFISLTAISK 

       550        560        570        580        590        600 
LPMDSRYQNS HSTAVDNPEY LNTNQSPLAK TVFESSPYWI QSGNHQINLD NPDYQQDFLP 


TSCS

P00535 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools